Zinc in PDB 7bai: Structure of Rig-I Ctd (I875A) Bound to P-Rna

All present enzymatic activity of Structure of Rig-I Ctd (I875A) Bound to P-Rna:
3.6.4.13;

The structure of Structure of Rig-I Ctd (I875A) Bound to P-Rna, PDB code: 7bai was solved by K.Anand, G.Hagelueken, D.Fusshoeller, M.Geyer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.70 / 3.40
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	84.523, 135.126, 110.374, 90, 90, 90
R / Rfree (%)	21.8 / 27.3

The binding sites of Zinc atom in the Structure of Rig-I Ctd (I875A) Bound to P-Rna (pdb code 7bai). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Structure of Rig-I Ctd (I875A) Bound to P-Rna, PDB code: 7bai:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in the Structure of Rig-I Ctd (I875A) Bound to P-Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Rig-I Ctd (I875A) Bound to P-Rna within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:135.2 occ:1.00 SG A:CYS869 2.3 134.6 1.0 SG A:CYS810 2.6 127.6 1.0 SG A:CYS813 2.6 140.0 1.0 SG A:CYS864 2.6 177.2 1.0 CB A:CYS869 3.0 138.9 1.0 CB A:CYS810 3.3 146.5 1.0 CB A:CYS864 3.4 146.8 1.0 CB A:CYS813 3.8 161.9 1.0 CZ2 A:TRP873 4.2 148.7 1.0 N A:CYS813 4.3 143.7 1.0 CA A:CYS869 4.5 141.7 1.0 CA A:CYS813 4.6 153.3 1.0 N A:SER870 4.7 152.8 1.0 CA A:CYS810 4.8 123.4 1.0 CB A:HIS871 4.8 144.3 1.0 CB A:ARG866 4.8 153.4 1.0 NE1 A:TRP873 4.8 185.9 1.0 CB A:ALA815 4.8 132.3 1.0 CA A:CYS864 4.8 138.7 1.0 CE2 A:TRP873 4.8 141.7 1.0 C A:CYS869 4.9 142.8 1.0 N A:HIS871 4.9 159.1 1.0 CB A:LYS812 4.9 129.1 1.0

Zinc binding site 2 out of 5 in the Structure of Rig-I Ctd (I875A) Bound to P-Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Rig-I Ctd (I875A) Bound to P-Rna within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1001 b:125.6 occ:1.00 SG B:CYS869 2.3 144.5 1.0 SG B:CYS813 2.4 132.7 1.0 SG B:CYS864 2.4 186.7 1.0 SG B:CYS810 2.5 121.1 1.0 CB B:CYS869 2.7 139.4 1.0 CB B:CYS813 3.2 125.4 1.0 CB B:CYS810 3.3 119.4 1.0 CB B:CYS864 3.3 136.5 1.0 N B:CYS813 3.8 148.2 1.0 CA B:CYS813 4.1 123.6 1.0 CA B:CYS869 4.2 150.4 1.0 CB B:ARG866 4.5 145.1 1.0 CB B:LYS812 4.7 122.8 1.0 CZ2 B:TRP873 4.7 143.9 1.0 CG B:ARG866 4.7 149.5 1.0 N B:SER870 4.7 172.1 1.0 CA B:CYS810 4.7 116.7 1.0 CA B:CYS864 4.8 130.7 1.0 C B:CYS813 4.8 124.1 1.0 C B:LYS812 4.8 137.8 1.0 C B:CYS869 4.9 162.6 1.0 CB B:HIS871 4.9 151.1 1.0 CB B:ALA815 5.0 123.7 1.0

Zinc binding site 3 out of 5 in the Structure of Rig-I Ctd (I875A) Bound to P-Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of Rig-I Ctd (I875A) Bound to P-Rna within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn1001 b:267.4 occ:1.00 SG E:CYS810 2.3 137.5 1.0 CB E:CYS864 2.5 127.6 1.0 SG E:CYS869 2.6 150.7 1.0 ZN E:ZN1002 2.6 140.7 1.0 CB E:HIS871 3.2 144.4 1.0 SG E:CYS864 3.4 174.2 1.0 NE1 E:TRP873 3.4 119.7 1.0 N E:HIS871 3.5 148.5 1.0 CB E:CYS810 3.7 115.4 1.0 CB E:CYS869 3.8 160.4 1.0 CA E:HIS871 3.9 144.9 1.0 CA E:CYS864 3.9 128.7 1.0 CE2 E:TRP873 4.1 142.6 1.0 N E:CYS864 4.2 125.2 1.0 O E:HIS871 4.2 144.2 1.0 CZ2 E:TRP873 4.2 139.2 1.0 N E:SER870 4.3 153.2 1.0 CD1 E:TRP873 4.4 129.4 1.0 CG E:HIS871 4.4 152.9 1.0 C E:HIS871 4.5 141.5 1.0 C E:SER870 4.6 159.5 1.0 C E:CYS869 4.6 187.6 1.0 CB E:LYS812 4.7 124.8 1.0 CA E:CYS869 4.8 183.8 1.0 CA E:SER870 4.8 152.6 1.0 SG E:CYS813 4.9 203.0 1.0 CA E:CYS810 4.9 112.5 1.0 C E:CYS864 4.9 183.3 1.0 CD2 E:HIS871 5.0 161.3 1.0

Zinc binding site 4 out of 5 in the Structure of Rig-I Ctd (I875A) Bound to P-Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of Rig-I Ctd (I875A) Bound to P-Rna within 5.0Å range: probe atom residue distance (Å) B Occ E:Zn1002 b:140.7 occ:1.00 SG E:CYS813 2.2 203.0 1.0 SG E:CYS869 2.5 150.7 1.0 ZN E:ZN1001 2.6 267.4 1.0 SG E:CYS810 2.7 137.5 1.0 CB E:CYS810 3.1 115.4 1.0 SG E:CYS864 3.2 174.2 1.0 CB E:CYS813 3.4 162.0 1.0 CB E:CYS869 3.5 160.4 1.0 CB E:CYS864 3.8 127.6 1.0 N E:CYS813 3.8 142.6 1.0 CA E:CYS813 4.1 135.2 1.0 CA E:CYS810 4.5 112.5 1.0 CB E:ALA815 4.5 116.5 1.0 CB E:ARG866 4.6 130.0 1.0 C E:CYS813 4.7 127.5 1.0 N E:ALA815 4.7 140.3 1.0 N E:LYS814 4.8 132.1 1.0 CB E:LYS812 4.9 124.8 1.0 C E:CYS810 4.9 131.1 1.0 CA E:CYS869 4.9 183.8 1.0 C E:LYS812 5.0 160.3 1.0

Zinc binding site 5 out of 5 in the Structure of Rig-I Ctd (I875A) Bound to P-Rna


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Structure of Rig-I Ctd (I875A) Bound to P-Rna within 5.0Å range:

A.K.De Regt, K.Anand, K.Gatterdam, G.Hagelueken, G.Hartmann, M.Geyer, M.Schlee. A Conserved Isoleucine in the Rna Sensor Rig-I Controls Immune Tolerance to Mitochondrial Rna To Be Published.