Atomistry » Zinc » PDB 6zxg-7a6v » 7a4x
Atomistry »
  Zinc »
    PDB 6zxg-7a6v »
      7a4x »

Zinc in PDB 7a4x: Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Dimethyl Sulfoxide

Enzymatic activity of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Dimethyl Sulfoxide

All present enzymatic activity of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Dimethyl Sulfoxide:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Dimethyl Sulfoxide, PDB code: 7a4x was solved by D.Nguyen, T.X.P.Nguyen, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 64.06 / 2.05
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 128.122, 128.122, 114.408, 90, 90, 120
R / Rfree (%) 17.1 / 20.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Dimethyl Sulfoxide (pdb code 7a4x). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Dimethyl Sulfoxide, PDB code: 7a4x:

Zinc binding site 1 out of 1 in 7a4x

Go back to Zinc Binding Sites List in 7a4x
Zinc binding site 1 out of 1 in the Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Dimethyl Sulfoxide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna-Guanine Transglycosylase C158S/C281S/Y330C/H333A Mutant in Complex with Dimethyl Sulfoxide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:23.0
occ:1.00
ND1 A:HIS349 2.1 23.3 1.0
SG A:CYS320 2.3 23.1 1.0
SG A:CYS323 2.3 23.0 1.0
SG A:CYS318 2.4 24.2 1.0
CE1 A:HIS349 3.0 25.9 1.0
CG A:HIS349 3.2 23.9 1.0
CB A:CYS318 3.3 21.6 1.0
CB A:CYS323 3.3 21.0 1.0
CB A:CYS320 3.3 24.4 1.0
CB A:HIS349 3.6 18.9 1.0
N A:CYS323 3.9 21.9 1.0
N A:CYS320 4.0 23.5 1.0
CA A:HIS349 4.1 20.6 1.0
NE2 A:HIS349 4.2 22.7 1.0
CA A:CYS320 4.2 24.0 1.0
CA A:CYS323 4.2 24.1 1.0
CD2 A:HIS349 4.3 22.9 1.0
O A:HIS349 4.5 19.5 1.0
CA A:CYS318 4.6 22.5 1.0
C A:CYS318 4.7 25.3 1.0
C A:CYS320 4.7 22.7 1.0
O A:CYS320 4.7 21.5 1.0
C A:HIS349 4.8 21.1 1.0
O A:CYS318 4.8 22.1 1.0
CB A:VAL322 4.8 22.3 1.0
C A:VAL322 4.9 24.3 1.0

Reference:

D.Nguyen, X.Xie, S.Jakobi, F.Terwesten, A.Metz, T.X.P.Nguyen, V.A.Palchykov, A.Heine, K.Reuter, G.Klebe. Targeting A Cryptic Pocket in A Protein-Protein Contact By Disulfide-Induced Rupture of A Homodimeric Interface Acs Chem.Biol. 2021.
ISSN: ESSN 1554-8937
DOI: 10.1021/ACSCHEMBIO.1C00296
Page generated: Mon Jul 12 16:50:45 2021

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy