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Zinc in PDB 7a1p: Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Propyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer)

Enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Propyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer)

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Propyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer):
1.14.11.30;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Propyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer), PDB code: 7a1p was solved by Y.Nakashima, L.Brewitz, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.20 / 1.76
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 85.945, 85.945, 147.628, 90, 90, 90
R / Rfree (%) 16.1 / 19.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Propyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer) (pdb code 7a1p). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Propyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer), PDB code: 7a1p:

Zinc binding site 1 out of 1 in 7a1p

Go back to Zinc Binding Sites List in 7a1p
Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Propyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Propyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:38.6
occ:1.00
 NE2 A:HIS279 2.0 35.5 1.0
O02 A:QW2505 2.1 39.2 1.0
OD2 A:ASP201 2.1 36.3 1.0
NE2 A:HIS199 2.1 37.1 1.0
O01 A:QW2505 2.3 38.5 1.0
C04 A:QW2505 2.8 42.4 1.0
C08 A:QW2505 2.8 41.3 1.0
CE1 A:HIS279 2.9 35.3 1.0
CE1 A:HIS199 3.0 39.4 1.0
CD2 A:HIS279 3.1 37.3 1.0
CD2 A:HIS199 3.1 37.4 1.0
HE1 A:HIS279 3.1 42.3 1.0
CG A:ASP201 3.1 36.6 1.0
HE1 A:HIS199 3.2 47.3 1.0
HD2 A:HIS279 3.3 44.8 1.0
HD2 A:HIS199 3.3 44.9 1.0
OD1 A:ASP201 3.5 34.9 1.0
HZ2 A:TRP296 3.5 47.0 1.0
O A:HOH660 3.7 36.7 1.0
H07 A:QW2505 4.0 57.3 1.0
O03 A:QW2505 4.0 38.0 1.0
ND1 A:HIS279 4.1 36.2 1.0
HB2 B:ASN16 4.1 47.1 1.0
ND1 A:HIS199 4.1 37.9 1.0
CG A:HIS279 4.2 35.5 1.0
CG A:HIS199 4.2 36.0 1.0
HD22 A:ASN205 4.3 43.9 1.0
H06 A:QW2505 4.3 57.3 1.0
C07 A:QW2505 4.3 36.0 1.0
HE1 A:TRP296 4.4 44.0 1.0
CZ2 A:TRP296 4.5 39.2 1.0
CB A:ASP201 4.5 34.4 1.0
HB2 A:ASP201 4.5 41.3 1.0
H03 A:QW2505 4.6 46.0 1.0
C02 A:QW2505 4.7 47.7 1.0
H01 A:QW2505 4.7 43.2 1.0
H B:ASN16 4.8 47.6 1.0
H02 A:QW2505 4.8 43.2 1.0
HD1 A:HIS279 4.8 43.5 1.0
HD21 A:ASN205 4.9 43.9 1.0
HD22 B:ASN16 4.9 45.3 1.0
HD1 A:HIS199 4.9 45.5 1.0
CG B:ASN16 4.9 37.9 1.0
ND2 B:ASN16 4.9 37.7 1.0
ND2 A:ASN205 4.9 36.5 1.0
CB B:ASN16 4.9 39.3 1.0

Reference:

Y.Nakashima, L.Brewitz, C.J.Schofield. 2-Oxoglutarate Derivatives Modulate the Catalytic Activity of Human Factor Inhibiting Hif-Alpha To Be Published.
Page generated: Tue Oct 29 16:17:16 2024

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