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Zinc in PDB 7a1o: Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Ethyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer)

Enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Ethyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer)

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Ethyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer):
1.14.11.30;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Ethyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer), PDB code: 7a1o was solved by Y.Nakashima, L.Brewitz, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 74.41 / 2.21
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.288, 86.288, 146.934, 90, 90, 90
R / Rfree (%) 21 / 24.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Ethyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer) (pdb code 7a1o). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Ethyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer), PDB code: 7a1o:

Zinc binding site 1 out of 1 in 7a1o

Go back to Zinc Binding Sites List in 7a1o
Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Ethyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II), 4-Ethyl-2- Oxoglutarate, and Consensus Ankyrin Repeat Domain (20-Mer) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:50.9
occ:1.00
 OD2 A:ASP201 2.1 62.3 1.0
NE2 A:HIS199 2.1 71.8 1.0
NE2 A:HIS279 2.1 68.7 1.0
O04 A:QVT505 2.1 71.9 1.0
O05 A:QVT505 2.3 76.8 1.0
C02 A:QVT505 2.8 72.1 1.0
C07 A:QVT505 2.9 74.5 1.0
CG A:ASP201 3.0 52.6 1.0
CD2 A:HIS199 3.0 65.3 1.0
CE1 A:HIS199 3.1 67.8 1.0
CD2 A:HIS279 3.1 65.1 1.0
CE1 A:HIS279 3.1 66.4 1.0
HD2 A:HIS199 3.2 78.3 1.0
OD1 A:ASP201 3.2 52.4 1.0
HD2 A:HIS279 3.3 78.1 1.0
HE1 A:HIS199 3.3 81.3 1.0
HE1 A:HIS279 3.3 79.7 1.0
HZ2 A:TRP296 3.5 69.7 1.0
HB2 B:ASN16 3.9 69.2 1.0
H05 A:QVT505 3.9 102.5 1.0
O A:HOH614 4.1 39.2 1.0
O03 A:QVT505 4.1 71.7 1.0
ND1 A:HIS199 4.1 66.7 1.0
H03 A:QVT505 4.1 102.5 1.0
CG A:HIS199 4.2 64.8 1.0
ND1 A:HIS279 4.2 65.4 1.0
CG A:HIS279 4.3 62.7 1.0
HD22 A:ASN205 4.4 63.7 1.0
C06 A:QVT505 4.4 75.0 1.0
CB A:ASP201 4.4 52.7 1.0
CZ2 A:TRP296 4.4 58.1 1.0
HB2 A:ASP201 4.5 63.3 1.0
C03 A:QVT505 4.5 85.3 1.0
HE1 A:TRP296 4.5 68.6 1.0
H B:ASN16 4.6 69.1 1.0
CG B:ASN16 4.7 58.8 1.0
CB B:ASN16 4.7 57.6 1.0
ND2 B:ASN16 4.8 56.8 1.0
H08 A:QVT505 4.8 89.7 1.0
HD22 B:ASN16 4.8 68.2 1.0
H09 A:QVT505 4.9 90.1 1.0
H10 A:QVT505 4.9 90.1 1.0
HD1 A:HIS199 4.9 80.1 1.0
HB3 A:ASP201 5.0 63.3 1.0

Reference:

Y.Nakashima, L.Brewitz, C.J.Schofield. 2-Oxoglutarate Derivatives Modulate the Catalytic Activity of Human Factor Inhibiting Hif-Alpha To Be Published.
Page generated: Tue Oct 29 16:16:26 2024

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