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Zinc in PDB 7a1k: Factor Inhibiting Hif-1 Alpha in Complex with Zn(II) and 3-((9,9- Dimethyl-9H-Fluoren-2-Yl)Methyl)-2-Oxoglutarate

Enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II) and 3-((9,9- Dimethyl-9H-Fluoren-2-Yl)Methyl)-2-Oxoglutarate

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II) and 3-((9,9- Dimethyl-9H-Fluoren-2-Yl)Methyl)-2-Oxoglutarate:
1.14.11.30;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II) and 3-((9,9- Dimethyl-9H-Fluoren-2-Yl)Methyl)-2-Oxoglutarate, PDB code: 7a1k was solved by Y.Nakashima, L.Brewitz, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.39 / 1.99
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.181, 86.181, 148.898, 90, 90, 90
R / Rfree (%) 20.7 / 22.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II) and 3-((9,9- Dimethyl-9H-Fluoren-2-Yl)Methyl)-2-Oxoglutarate (pdb code 7a1k). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II) and 3-((9,9- Dimethyl-9H-Fluoren-2-Yl)Methyl)-2-Oxoglutarate, PDB code: 7a1k:

Zinc binding site 1 out of 1 in 7a1k

Go back to Zinc Binding Sites List in 7a1k
Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Zn(II) and 3-((9,9- Dimethyl-9H-Fluoren-2-Yl)Methyl)-2-Oxoglutarate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Zn(II) and 3-((9,9- Dimethyl-9H-Fluoren-2-Yl)Methyl)-2-Oxoglutarate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:58.0
occ:1.00
 O02 A:QVZ402 1.9 89.5 1.0
OD2 A:ASP201 2.1 86.8 1.0
NE2 A:HIS199 2.1 90.0 1.0
NE2 A:HIS279 2.2 81.4 1.0
O01 A:QVZ402 2.2 75.1 1.0
O A:HOH502 2.3 559.1 1.0
C20 A:QVZ402 2.7 66.6 1.0
C01 A:QVZ402 2.8 75.2 1.0
CD2 A:HIS279 3.0 71.9 1.0
CG A:ASP201 3.0 48.0 1.0
CE1 A:HIS199 3.0 76.3 1.0
HD2 A:HIS279 3.0 86.4 1.0
CD2 A:HIS199 3.1 58.4 1.0
HE1 A:HIS199 3.2 91.6 1.0
CE1 A:HIS279 3.2 85.8 1.0
OD1 A:ASP201 3.3 52.2 1.0
HD2 A:HIS199 3.3 70.2 1.0
H06 A:QVZ402 3.5 158.1 1.0
HZ2 A:TRP296 3.5 102.9 1.0
HE1 A:HIS279 3.5 103.0 1.0
O03 A:QVZ402 3.9 80.8 1.0
O A:HOH505 4.0 62.1 1.0
ND1 A:HIS199 4.1 71.7 1.0
CG A:HIS199 4.2 77.3 1.0
CG A:HIS279 4.2 76.1 1.0
ND1 A:HIS279 4.3 79.3 1.0
C02 A:QVZ402 4.3 72.9 1.0
CZ2 A:TRP296 4.4 85.7 1.0
CB A:ASP201 4.4 52.3 1.0
HD22 A:ASN205 4.5 71.7 1.0
HE1 A:TYR102 4.5 156.7 1.0
C06 A:QVZ402 4.5 131.7 1.0
HB2 A:ASP201 4.6 62.8 1.0
H04 A:QVZ402 4.6 71.7 1.0
HE1 A:TRP296 4.6 91.2 1.0
H01 A:QVZ402 4.8 87.5 1.0
HD1 A:HIS199 4.9 86.1 1.0
CE1 A:TYR102 4.9 130.6 1.0
C04 A:QVZ402 4.9 59.7 1.0
H05 A:QVZ402 4.9 71.7 1.0
HB3 A:ASP201 5.0 62.8 1.0
C05 A:QVZ402 5.0 110.1 1.0
C03 A:QVZ402 5.0 83.1 1.0

Reference:

Y.Nakashima, L.Brewitz, C.J.Schofield. 2-Oxoglutarate Derivatives Modulate the Catalytic Activity of Human Factor Inhibiting Hif-Alpha To Be Published.
Page generated: Tue Oct 29 16:15:21 2024

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