Zinc in PDB 6zu4: Human SIRT6 13-308 in Complex with Adp-Ribose and the Activator Fluvastatin

All present enzymatic activity of Human SIRT6 13-308 in Complex with Adp-Ribose and the Activator Fluvastatin:
2.3.1.286;

The structure of Human SIRT6 13-308 in Complex with Adp-Ribose and the Activator Fluvastatin, PDB code: 6zu4 was solved by W.You, C.Steegborn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.70 / 2.46
Space group	P 63
Cell size a, b, c (Å), α, β, γ (°)	91.407, 91.407, 144.277, 90.00, 90.00, 120.00
R / Rfree (%)	15.2 / 20.5

The structure of Human SIRT6 13-308 in Complex with Adp-Ribose and the Activator Fluvastatin also contains other interesting chemical elements:

Fluorine

(F)

1 atom

The binding sites of Zinc atom in the Human SIRT6 13-308 in Complex with Adp-Ribose and the Activator Fluvastatin (pdb code 6zu4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human SIRT6 13-308 in Complex with Adp-Ribose and the Activator Fluvastatin, PDB code: 6zu4:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human SIRT6 13-308 in Complex with Adp-Ribose and the Activator Fluvastatin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human SIRT6 13-308 in Complex with Adp-Ribose and the Activator Fluvastatin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:61.0 occ:1.00 SG A:CYS144 2.1 63.0 1.0 SG A:CYS141 2.2 50.3 1.0 SG A:CYS166 2.4 51.9 1.0 SG A:CYS177 2.4 77.3 1.0 CB A:CYS166 3.0 55.6 1.0 CB A:CYS141 3.0 52.4 1.0 CB A:CYS144 3.4 69.2 1.0 CB A:CYS177 3.5 71.1 1.0 N A:CYS144 3.7 58.9 1.0 CA A:CYS144 4.1 59.1 1.0 CA A:CYS166 4.5 48.3 1.0 CB A:LYS143 4.5 75.4 1.0 CA A:CYS141 4.5 50.4 1.0 N A:GLY179 4.7 70.8 1.0 C A:CYS144 4.8 61.0 1.0 CG2 A:VAL168 4.8 73.5 1.0 C A:LYS143 4.8 64.5 1.0 CA A:GLY179 4.8 68.7 1.0 CA A:CYS177 4.9 64.1 1.0 CB A:VAL168 4.9 65.5 1.0 N A:LYS145 4.9 60.6 1.0 OG1 A:THR146 5.0 63.7 1.0 CB A:THR146 5.0 55.4 1.0

Zinc binding site 2 out of 2 in the Human SIRT6 13-308 in Complex with Adp-Ribose and the Activator Fluvastatin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human SIRT6 13-308 in Complex with Adp-Ribose and the Activator Fluvastatin within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn402 b:62.8 occ:1.00 SG B:CYS141 2.1 69.9 1.0 SG B:CYS166 2.4 65.9 1.0 SG B:CYS144 2.4 65.3 1.0 SG B:CYS177 2.5 76.5 1.0 CB B:CYS166 2.8 55.9 1.0 CB B:CYS141 2.9 74.8 1.0 CB B:CYS144 3.6 78.7 1.0 N B:CYS144 3.7 77.9 1.0 CB B:CYS177 3.7 71.9 1.0 CA B:CYS144 4.2 76.3 1.0 CA B:CYS166 4.3 56.2 1.0 CA B:CYS141 4.4 77.1 1.0 CB B:LYS143 4.5 79.5 1.0 N B:GLY179 4.7 68.9 1.0 C B:LYS143 4.8 74.9 1.0 CA B:GLY179 4.8 77.7 1.0 C B:CYS144 4.9 73.2 1.0 CG2 B:VAL168 4.9 77.4 1.0 N B:LYS145 5.0 76.2 1.0 CB B:THR146 5.0 54.8 1.0 C B:CYS141 5.0 81.0 1.0

W.You, C.Steegborn. Structural Basis For Activation of Human Sirtuin 6 By Fluvastatin. Acs Med.Chem.Lett. V. 11 2285 2020.
ISSN: ISSN 1948-5875
PubMed: 33214841
DOI: 10.1021/ACSMEDCHEMLETT.0C00407