Zinc in PDB 6z80: Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex

Enzymatic activity of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex

All present enzymatic activity of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex:
3.5.4.16;

Zinc Binding Sites:

The binding sites of Zinc atom in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex (pdb code 6z80). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 10 binding sites of Zinc where determined in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex, PDB code: 6z80:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Zinc binding site 1 out of 10 in 6z80

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Zinc binding site 1 out of 10 in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:0.0
occ:1.00
 O8 B:8GT301 2.2 0.0 1.0
SG A:CYS141 2.4 0.0 1.0
SG A:CYS212 2.5 0.0 1.0
ND1 A:HIS144 2.8 0.0 1.0
C8 B:8GT301 3.0 0.0 1.0
N7 B:8GT301 3.4 0.0 1.0
CB A:CYS141 3.4 0.0 1.0
CB A:CYS212 3.4 0.0 1.0
CG A:HIS144 3.6 0.0 1.0
CB A:HIS144 3.7 0.0 1.0
N A:HIS144 3.7 0.0 1.0
CE1 A:HIS144 3.8 0.0 1.0
CB A:HIS143 4.2 0.0 1.0
CA A:HIS144 4.3 0.0 1.0
N9 B:8GT301 4.4 0.0 1.0
N A:HIS143 4.6 0.0 1.0
C A:HIS143 4.6 0.0 1.0
CA A:HIS143 4.7 0.0 1.0
C5 B:8GT301 4.7 0.0 1.0
CA A:CYS141 4.8 0.0 1.0
CA A:CYS212 4.8 0.0 1.0
CD2 A:HIS144 4.8 0.0 1.0
NE2 A:HIS144 4.9 0.0 1.0
CG A:HIS143 5.0 0.0 1.0
O A:VAL146 5.0 0.0 1.0

Zinc binding site 2 out of 10 in 6z80

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Zinc binding site 2 out of 10 in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn302

b:0.0
occ:1.00
 O8 C:8GT301 2.2 0.0 1.0
SG B:CYS141 2.4 0.0 1.0
SG B:CYS212 2.5 0.0 1.0
ND1 B:HIS144 2.8 0.0 1.0
C8 C:8GT301 3.1 0.0 1.0
CB B:CYS141 3.4 0.0 1.0
CB B:CYS212 3.4 0.0 1.0
N7 C:8GT301 3.4 0.0 1.0
CG B:HIS144 3.6 0.0 1.0
CB B:HIS144 3.7 0.0 1.0
N B:HIS144 3.7 0.0 1.0
CE1 B:HIS144 3.8 0.0 1.0
CB B:HIS143 4.2 0.0 1.0
CA B:HIS144 4.3 0.0 1.0
N9 C:8GT301 4.4 0.0 1.0
N B:HIS143 4.6 0.0 1.0
C B:HIS143 4.6 0.0 1.0
CA B:HIS143 4.7 0.0 1.0
CA B:CYS141 4.8 0.0 1.0
C5 C:8GT301 4.8 0.0 1.0
CA B:CYS212 4.8 0.0 1.0
CD2 B:HIS144 4.8 0.0 1.0
NE2 B:HIS144 4.9 0.0 1.0
CG B:HIS143 5.0 0.0 1.0
O B:VAL146 5.0 0.0 1.0

Zinc binding site 3 out of 10 in 6z80

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Zinc binding site 3 out of 10 in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn302

b:0.0
occ:1.00
 O8 D:8GT302 2.3 0.0 1.0
SG C:CYS141 2.4 0.0 1.0
SG C:CYS212 2.5 0.0 1.0
ND1 C:HIS144 2.8 0.0 1.0
C8 D:8GT302 3.1 0.0 1.0
N7 D:8GT302 3.3 0.0 1.0
CB C:CYS141 3.4 0.0 1.0
CB C:CYS212 3.4 0.0 1.0
CG C:HIS144 3.6 0.0 1.0
CB C:HIS144 3.7 0.0 1.0
N C:HIS144 3.7 0.0 1.0
CE1 C:HIS144 3.8 0.0 1.0
CB C:HIS143 4.2 0.0 1.0
CA C:HIS144 4.3 0.0 1.0
N9 D:8GT302 4.4 0.0 1.0
N C:HIS143 4.6 0.0 1.0
C C:HIS143 4.6 0.0 1.0
C5 D:8GT302 4.7 0.0 1.0
CA C:HIS143 4.7 0.0 1.0
CA C:CYS141 4.8 0.0 1.0
CA C:CYS212 4.8 0.0 1.0
CD2 C:HIS144 4.8 0.0 1.0
NE2 C:HIS144 4.9 0.0 1.0
CG C:HIS143 5.0 0.0 1.0
O C:VAL146 5.0 0.0 1.0

Zinc binding site 4 out of 10 in 6z80

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Zinc binding site 4 out of 10 in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Zn302

b:0.0
occ:1.00
 O8 E:8GT301 2.0 0.0 1.0
SG E:CYS141 2.4 0.0 1.0
SG E:CYS212 2.5 0.0 1.0
ND1 E:HIS144 2.8 0.0 1.0
C8 E:8GT301 2.9 0.0 1.0
N7 E:8GT301 3.3 0.0 1.0
CB E:CYS141 3.4 0.0 1.0
CB E:CYS212 3.4 0.0 1.0
CG E:HIS144 3.6 0.0 1.0
CB E:HIS144 3.7 0.0 1.0
N E:HIS144 3.7 0.0 1.0
CE1 E:HIS144 3.8 0.0 1.0
CB E:HIS143 4.2 0.0 1.0
N9 E:8GT301 4.3 0.0 1.0
CA E:HIS144 4.3 0.0 1.0
N E:HIS143 4.6 0.0 1.0
C E:HIS143 4.6 0.0 1.0
CA E:HIS143 4.7 0.0 1.0
C5 E:8GT301 4.7 0.0 1.0
CA E:CYS141 4.8 0.0 1.0
CA E:CYS212 4.8 0.0 1.0
CD2 E:HIS144 4.8 0.0 1.0
NE2 E:HIS144 4.9 0.0 1.0
CG E:HIS143 5.0 0.0 1.0
O4' E:8GT301 5.0 0.0 1.0
O E:VAL146 5.0 0.0 1.0

Zinc binding site 5 out of 10 in 6z80

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Zinc binding site 5 out of 10 in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Zn301

b:0.0
occ:1.00
 O8 H:8GT301 2.3 0.0 1.0
SG G:CYS141 2.4 0.0 1.0
SG G:CYS212 2.5 0.0 1.0
ND1 G:HIS144 2.8 0.0 1.0
C8 H:8GT301 3.1 0.0 1.0
CB G:CYS141 3.4 0.0 1.0
CB G:CYS212 3.4 0.0 1.0
N7 H:8GT301 3.5 0.0 1.0
CG G:HIS144 3.6 0.0 1.0
CB G:HIS144 3.7 0.0 1.0
N G:HIS144 3.7 0.0 1.0
CE1 G:HIS144 3.8 0.0 1.0
CB G:HIS143 4.2 0.0 1.0
CA G:HIS144 4.3 0.0 1.0
N9 H:8GT301 4.5 0.0 1.0
N G:HIS143 4.6 0.0 1.0
C G:HIS143 4.6 0.0 1.0
CA G:HIS143 4.7 0.0 1.0
CA G:CYS141 4.8 0.0 1.0
CA G:CYS212 4.8 0.0 1.0
CD2 G:HIS144 4.8 0.0 1.0
C5 H:8GT301 4.8 0.0 1.0
NE2 G:HIS144 4.9 0.0 1.0
CG G:HIS143 5.0 0.0 1.0
O G:VAL146 5.0 0.0 1.0

Zinc binding site 6 out of 10 in 6z80

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Zinc binding site 6 out of 10 in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Zn302

b:0.0
occ:1.00
 O8 I:8GT301 2.1 0.0 1.0
SG H:CYS141 2.4 0.0 1.0
SG H:CYS212 2.5 0.0 1.0
ND1 H:HIS144 2.8 0.0 1.0
C8 I:8GT301 3.0 0.0 1.0
CB H:CYS141 3.4 0.0 1.0
CB H:CYS212 3.4 0.0 1.0
N7 I:8GT301 3.4 0.0 1.0
CG H:HIS144 3.6 0.0 1.0
CB H:HIS144 3.7 0.0 1.0
N H:HIS144 3.7 0.0 1.0
CE1 H:HIS144 3.8 0.0 1.0
CB H:HIS143 4.2 0.0 1.0
CA H:HIS144 4.3 0.0 1.0
N9 I:8GT301 4.4 0.0 1.0
N H:HIS143 4.6 0.0 1.0
C H:HIS143 4.6 0.0 1.0
CA H:HIS143 4.7 0.0 1.0
C5 I:8GT301 4.8 0.0 1.0
CA H:CYS141 4.8 0.0 1.0
CA H:CYS212 4.8 0.0 1.0
CD2 H:HIS144 4.8 0.0 1.0
NE2 H:HIS144 4.9 0.0 1.0
CG H:HIS143 5.0 0.0 1.0
O H:VAL146 5.0 0.0 1.0

Zinc binding site 7 out of 10 in 6z80

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Zinc binding site 7 out of 10 in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Zn302

b:0.0
occ:1.00
 O8 J:8GT301 2.2 0.0 1.0
SG I:CYS141 2.4 0.0 1.0
SG I:CYS212 2.5 0.0 1.0
ND1 I:HIS144 2.8 0.0 1.0
C8 J:8GT301 3.1 0.0 1.0
CB I:CYS141 3.4 0.0 1.0
CB I:CYS212 3.4 0.0 1.0
N7 J:8GT301 3.4 0.0 1.0
CG I:HIS144 3.6 0.0 1.0
CB I:HIS144 3.7 0.0 1.0
N I:HIS144 3.7 0.0 1.0
CE1 I:HIS144 3.8 0.0 1.0
CB I:HIS143 4.2 0.0 1.0
CA I:HIS144 4.3 0.0 1.0
N9 J:8GT301 4.4 0.0 1.0
N I:HIS143 4.6 0.0 1.0
C I:HIS143 4.6 0.0 1.0
CA I:HIS143 4.7 0.0 1.0
CA I:CYS141 4.8 0.0 1.0
C5 J:8GT301 4.8 0.0 1.0
CA I:CYS212 4.8 0.0 1.0
CD2 I:HIS144 4.8 0.0 1.0
NE2 I:HIS144 4.9 0.0 1.0
CG I:HIS143 5.0 0.0 1.0
O I:VAL146 5.0 0.0 1.0

Zinc binding site 8 out of 10 in 6z80

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Zinc binding site 8 out of 10 in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Zn302

b:0.0
occ:1.00
 O8 F:8GT302 2.3 0.0 1.0
SG J:CYS141 2.4 0.0 1.0
SG J:CYS212 2.5 0.0 1.0
ND1 J:HIS144 2.8 0.0 1.0
C8 F:8GT302 3.1 0.0 1.0
N7 F:8GT302 3.4 0.0 1.0
CB J:CYS141 3.4 0.0 1.0
CB J:CYS212 3.4 0.0 1.0
CG J:HIS144 3.6 0.0 1.0
CB J:HIS144 3.7 0.0 1.0
N J:HIS144 3.7 0.0 1.0
CE1 J:HIS144 3.8 0.0 1.0
CB J:HIS143 4.2 0.0 1.0
CA J:HIS144 4.3 0.0 1.0
N9 F:8GT302 4.4 0.0 1.0
N J:HIS143 4.6 0.0 1.0
C J:HIS143 4.6 0.0 1.0
CA J:HIS143 4.7 0.0 1.0
C5 F:8GT302 4.7 0.0 1.0
CA J:CYS141 4.8 0.0 1.0
CA J:CYS212 4.8 0.0 1.0
CD2 J:HIS144 4.8 0.0 1.0
NE2 J:HIS144 4.9 0.0 1.0
CG J:HIS143 5.0 0.0 1.0
O J:VAL146 5.0 0.0 1.0

Zinc binding site 9 out of 10 in 6z80

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Zinc binding site 9 out of 10 in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 9 of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Zn303

b:0.0
occ:1.00
 O8 F:8GT301 2.1 0.0 1.0
SG F:CYS141 2.4 0.0 1.0
SG F:CYS212 2.5 0.0 1.0
ND1 F:HIS144 2.8 0.0 1.0
C8 F:8GT301 3.1 0.0 1.0
CB F:CYS141 3.4 0.0 1.0
CB F:CYS212 3.4 0.0 1.0
N7 F:8GT301 3.4 0.0 1.0
CG F:HIS144 3.6 0.0 1.0
CB F:HIS144 3.7 0.0 1.0
N F:HIS144 3.7 0.0 1.0
CE1 F:HIS144 3.8 0.0 1.0
CB F:HIS143 4.2 0.0 1.0
CA F:HIS144 4.3 0.0 1.0
N9 F:8GT301 4.4 0.0 1.0
N F:HIS143 4.6 0.0 1.0
C F:HIS143 4.6 0.0 1.0
CA F:HIS143 4.7 0.0 1.0
CA F:CYS141 4.8 0.0 1.0
C5 F:8GT301 4.8 0.0 1.0
CA F:CYS212 4.8 0.0 1.0
CD2 F:HIS144 4.8 0.0 1.0
NE2 F:HIS144 4.9 0.0 1.0
CG F:HIS143 5.0 0.0 1.0
O F:VAL146 5.0 0.0 1.0

Zinc binding site 10 out of 10 in 6z80

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Zinc binding site 10 out of 10 in the Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 10 of Stimulatory Human Gtp Cyclohydrolase I - Gfrp Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn303

b:0.0
occ:1.00
 O8 D:8GT301 2.2 0.0 1.0
SG D:CYS141 2.4 0.0 1.0
SG D:CYS212 2.5 0.0 1.0
ND1 D:HIS144 2.8 0.0 1.0
C8 D:8GT301 3.1 0.0 1.0
CB D:CYS141 3.4 0.0 1.0
CB D:CYS212 3.4 0.0 1.0
N7 D:8GT301 3.4 0.0 1.0
CG D:HIS144 3.6 0.0 1.0
CB D:HIS144 3.7 0.0 1.0
N D:HIS144 3.7 0.0 1.0
CE1 D:HIS144 3.8 0.0 1.0
CB D:HIS143 4.2 0.0 1.0
CA D:HIS144 4.3 0.0 1.0
N9 D:8GT301 4.4 0.0 1.0
N D:HIS143 4.6 0.0 1.0
C D:HIS143 4.6 0.0 1.0
CA D:HIS143 4.7 0.0 1.0
CA D:CYS141 4.8 0.0 1.0
C5 D:8GT301 4.8 0.0 1.0
CA D:CYS212 4.8 0.0 1.0
CD2 D:HIS144 4.8 0.0 1.0
NE2 D:HIS144 4.9 0.0 1.0
CG D:HIS143 5.0 0.0 1.0
O D:VAL146 5.0 0.0 1.0

Reference:

R.Ebenhoch, S.Prinz, S.Kaltwasser, D.J.Mills, R.Meinecke, M.Rubbelke, D.Reinert, M.Bauer, L.Weixler, M.Zeeb, J.Vonck, H.Nar. A Hybrid Approach Reveals the Allosteric Regulation of Gtp Cyclohydrolase I. Proc.Natl.Acad.Sci.Usa 2020.
ISSN: ESSN 1091-6490
PubMed: 33229582
DOI: 10.1073/PNAS.2013473117
Page generated: Wed Dec 16 13:22:18 2020

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