Zinc in PDB 6z6f: Hdac-Pc

All present enzymatic activity of Hdac-Pc:
3.5.1.98;

The binding sites of Zinc atom in the Hdac-Pc (pdb code 6z6f). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Hdac-Pc, PDB code: 6z6f:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Hdac-Pc


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Hdac-Pc within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn801 b:135.1 occ:1.00 OD2 A:ASP338 2.2 101.8 1.0 ND1 A:HIS247 2.2 97.4 1.0 OD2 A:ASP245 2.3 97.0 1.0 OD1 A:ASP245 2.3 97.0 1.0 CG A:ASP245 2.7 97.0 1.0 CE1 A:HIS247 3.0 97.4 1.0 CG A:ASP338 3.3 101.8 1.0 CG A:HIS247 3.4 97.4 1.0 CB A:HIS247 3.8 97.4 1.0 OD1 A:ASP338 3.9 101.8 1.0 NE2 A:HIS247 4.2 97.4 1.0 CB A:ASP245 4.2 97.0 1.0 N A:HIS247 4.2 97.4 1.0 NE2 A:HIS205 4.3 98.8 1.0 CD2 A:HIS247 4.4 97.4 1.0 CB A:ASP338 4.5 101.8 1.0 CE1 A:HIS205 4.6 98.8 1.0 CA A:HIS247 4.7 97.4 1.0 N A:ILE246 4.7 95.3 1.0 CA A:GLY376 4.8 101.5 1.0

Zinc binding site 2 out of 2 in the Hdac-Pc


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Hdac-Pc within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn801 b:143.2 occ:1.00 ND1 B:HIS247 2.2 103.9 1.0 OD2 B:ASP338 2.2 113.9 1.0 OD1 B:ASP245 2.5 104.8 1.0 OD2 B:ASP245 2.5 104.8 1.0 CE1 B:HIS247 2.7 103.9 1.0 CG B:ASP245 2.9 104.8 1.0 CG B:ASP338 3.4 113.9 1.0 CG B:HIS247 3.5 103.9 1.0 OD1 B:ASP338 3.9 113.9 1.0 OH B:TYR378 4.0 116.6 1.0 NE2 B:HIS247 4.0 103.9 1.0 CB B:HIS247 4.2 103.9 1.0 CE2 B:TYR378 4.3 116.6 1.0 CD2 B:HIS247 4.4 103.9 1.0 NE2 B:HIS205 4.4 103.4 1.0 CB B:ASP245 4.4 104.8 1.0 N B:HIS247 4.4 103.9 1.0 CA B:GLY376 4.6 112.1 1.0 CB B:ASP338 4.6 113.9 1.0 CZ B:TYR378 4.6 116.6 1.0 N B:ILE246 4.8 105.5 1.0 CE1 B:HIS205 4.8 103.4 1.0 CG2 B:ILE246 4.9 105.5 1.0 CA B:HIS247 5.0 103.9 1.0

J.H.Lee, D.Bollschweiler, T.Schafer, R.Huber. Structural Basis For the Regulation of Nucleosome Recognition and Hdac Activity By Histone Deacetylase Assemblies. Sci Adv V. 7 2021.
ISSN: ESSN 2375-2548
PubMed: 33523989
DOI: 10.1126/SCIADV.ABD4413