Zinc in PDB 6t7l: Crystal Structure of Ampc From E.Coli with Nacubactam (OP0595)

Enzymatic activity of Crystal Structure of Ampc From E.Coli with Nacubactam (OP0595)

All present enzymatic activity of Crystal Structure of Ampc From E.Coli with Nacubactam (OP0595):
3.5.2.6;

Protein crystallography data

The structure of Crystal Structure of Ampc From E.Coli with Nacubactam (OP0595), PDB code: 6t7l was solved by P.A.Lang, T.M.Leissing, C.J.Schofield, J.Brem, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.85 / 1.47
Space group P 43 3 2
Cell size a, b, c (Å), α, β, γ (°) 138.178, 138.178, 138.178, 90.00, 90.00, 90.00
R / Rfree (%) 15.5 / 18.2

Other elements in 6t7l:

The structure of Crystal Structure of Ampc From E.Coli with Nacubactam (OP0595) also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Ampc From E.Coli with Nacubactam (OP0595) (pdb code 6t7l). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Ampc From E.Coli with Nacubactam (OP0595), PDB code: 6t7l:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 6t7l

Go back to Zinc Binding Sites List in 6t7l
Zinc binding site 1 out of 2 in the Crystal Structure of Ampc From E.Coli with Nacubactam (OP0595)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Ampc From E.Coli with Nacubactam (OP0595) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn403

b:13.8
occ:0.33
NE2 A:HIS13 2.1 11.4 1.0
CL A:CL407 2.2 17.4 0.3
CD2 A:HIS13 3.0 12.1 1.0
CE1 A:HIS13 3.1 12.9 1.0
ND1 A:HIS13 4.2 13.7 1.0
CG A:HIS13 4.2 13.2 1.0

Zinc binding site 2 out of 2 in 6t7l

Go back to Zinc Binding Sites List in 6t7l
Zinc binding site 2 out of 2 in the Crystal Structure of Ampc From E.Coli with Nacubactam (OP0595)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Ampc From E.Coli with Nacubactam (OP0595) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn404

b:29.4
occ:0.50
O A:HOH531 2.0 36.9 1.0
O A:HOH765 2.1 47.4 1.0
NE2 A:HIS186 2.2 25.8 1.0
O A:HOH807 2.2 47.2 1.0
O A:HOH566 2.3 44.8 1.0
CE1 A:HIS186 3.1 26.2 1.0
CD2 A:HIS186 3.2 24.6 1.0
O A:HOH787 4.0 40.8 1.0
O A:HOH606 4.1 35.0 1.0
OE2 A:GLU195 4.1 35.3 1.0
ND1 A:HIS186 4.3 24.6 1.0
OE1 A:GLU195 4.3 32.1 1.0
CG A:HIS186 4.3 22.4 1.0
CD A:GLU195 4.6 33.2 1.0

Reference:

P.A.Lang, T.M.Leissing, M.G.P.Page, C.J.Schofield, J.Brem. Structural Investigations of the Inhibition of Escherichia Coli Ampc Beta-Lactamase By Diazabicyclooctanes. Antimicrob.Agents Chemother. 2020.
ISSN: ESSN 1098-6596
PubMed: 33199391
DOI: 10.1128/AAC.02073-20
Page generated: Wed Dec 16 12:51:53 2020

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