Zinc in PDB 6guu: Structure of CHD5 PHD2 - Tandem Chromodomains

All present enzymatic activity of Structure of CHD5 PHD2 - Tandem Chromodomains:
3.6.4.12;

The structure of Structure of CHD5 PHD2 - Tandem Chromodomains, PDB code: 6guu was solved by A.Alt, E.J.Mancini, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	51.94 / 2.95
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	131.628, 131.628, 84.569, 90.00, 90.00, 90.00
R / Rfree (%)	20.6 / 26.3

The binding sites of Zinc atom in the Structure of CHD5 PHD2 - Tandem Chromodomains (pdb code 6guu). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of CHD5 PHD2 - Tandem Chromodomains, PDB code: 6guu:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of CHD5 PHD2 - Tandem Chromodomains


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of CHD5 PHD2 - Tandem Chromodomains within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn701 b:0.2 occ:1.00 SG A:CYS457 2.2 94.0 1.0 SG A:CYS434 2.3 0.9 1.0 SG A:CYS460 2.4 0.2 1.0 SG A:CYS431 2.4 0.1 1.0 CB A:CYS434 2.9 0.2 1.0 CB A:CYS460 3.0 98.8 1.0 CB A:CYS431 3.2 0.4 1.0 N A:CYS434 3.4 0.9 1.0 CB A:CYS457 3.4 0.7 1.0 CA A:CYS434 3.7 0.3 1.0 N A:CYS457 3.9 0.9 1.0 N A:CYS460 4.0 0.5 1.0 CA A:CYS460 4.1 0.5 1.0 O A:CYS434 4.1 0.4 1.0 C A:CYS434 4.2 1.0 1.0 C A:ALA433 4.2 0.7 1.0 CA A:CYS457 4.2 0.4 1.0 CB A:ALA433 4.4 0.7 1.0 OG A:SER436 4.5 0.5 1.0 CG A:ARG459 4.5 0.9 1.0 CB A:SER436 4.6 0.5 1.0 CA A:ALA433 4.7 0.5 1.0 N A:ALA433 4.7 0.1 1.0 CA A:CYS431 4.7 0.9 1.0 O A:CYS457 4.8 0.0 1.0 C A:CYS457 4.9 0.8 1.0 N A:SER436 5.0 94.5 1.0

Zinc binding site 2 out of 4 in the Structure of CHD5 PHD2 - Tandem Chromodomains


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of CHD5 PHD2 - Tandem Chromodomains within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn702 b:0.1 occ:1.00 SG A:CYS419 2.3 0.5 1.0 SG A:CYS422 2.3 0.3 1.0 ND1 A:HIS439 2.3 0.9 1.0 SG A:CYS442 2.5 0.4 1.0 CB A:CYS419 2.6 0.9 1.0 CB A:HIS439 2.7 0.0 1.0 CG A:HIS439 2.7 0.2 1.0 CB A:CYS422 3.1 0.6 1.0 CE1 A:HIS439 3.4 0.6 1.0 CB A:CYS442 3.6 0.3 1.0 N A:HIS439 3.7 0.6 1.0 CA A:HIS439 3.8 0.4 1.0 CD2 A:HIS439 3.8 0.2 1.0 N A:CYS422 3.8 0.2 1.0 CA A:CYS422 4.0 1.0 1.0 CA A:CYS419 4.1 0.5 1.0 NE2 A:HIS439 4.1 0.6 1.0 NE2 A:HIS441 4.3 0.2 1.0 O A:HIS439 4.7 0.4 1.0 C A:CYS422 4.7 0.5 1.0 C A:HIS439 4.7 0.5 1.0 C A:CYS419 4.7 0.6 1.0 CE1 A:HIS441 4.7 0.3 1.0 O A:ASP424 4.8 0.9 1.0 C A:TYR438 4.9 0.1 1.0 C A:VAL421 4.9 0.4 1.0 CD2 A:HIS441 4.9 0.5 1.0 N A:CYS419 4.9 0.8 1.0 CA A:CYS442 5.0 0.5 1.0 O A:CYS419 5.0 0.5 1.0 CB A:VAL421 5.0 0.1 1.0

Zinc binding site 3 out of 4 in the Structure of CHD5 PHD2 - Tandem Chromodomains


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of CHD5 PHD2 - Tandem Chromodomains within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn701 b:0.9 occ:1.00 SG B:CYS442 2.3 0.7 1.0 SG B:CYS419 2.3 0.1 1.0 SG B:CYS422 2.4 0.1 1.0 ND1 B:HIS439 2.7 0.5 1.0 CB B:HIS439 2.9 0.2 1.0 CB B:CYS442 2.9 0.9 1.0 CB B:CYS419 3.0 0.1 1.0 CG B:HIS439 3.0 0.0 1.0 CB B:CYS422 3.2 0.5 1.0 N B:CYS422 3.5 96.6 1.0 CE1 B:HIS439 3.7 0.6 1.0 N B:HIS439 3.8 0.6 1.0 CA B:HIS439 3.9 1.0 1.0 CA B:CYS422 4.0 0.9 1.0 CD2 B:HIS439 4.1 0.3 1.0 CA B:CYS442 4.4 0.4 1.0 CB B:VAL421 4.4 0.9 1.0 NE2 B:HIS439 4.4 0.3 1.0 CA B:CYS419 4.5 0.2 1.0 NE2 B:HIS441 4.5 0.8 1.0 C B:VAL421 4.5 0.7 1.0 O B:HIS439 4.7 0.2 1.0 N B:VAL421 4.7 0.1 1.0 C B:CYS422 4.7 0.5 1.0 C B:HIS439 4.7 0.4 1.0 CA B:VAL421 4.8 1.0 1.0 N B:CYS442 4.8 0.3 1.0 N B:LYS423 4.8 0.5 1.0 C B:CYS419 4.9 0.8 1.0 CE1 B:HIS441 4.9 0.9 1.0 C B:TYR438 5.0 0.2 1.0

Zinc binding site 4 out of 4 in the Structure of CHD5 PHD2 - Tandem Chromodomains


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of CHD5 PHD2 - Tandem Chromodomains within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn702 b:0.7 occ:1.00 SG B:CYS434 1.8 0.6 1.0 SG B:CYS457 2.3 0.1 1.0 SG B:CYS431 2.3 0.2 1.0 SG B:CYS460 2.4 97.9 1.0 CB B:CYS431 2.9 0.6 1.0 CB B:CYS434 3.2 0.6 1.0 CB B:CYS457 3.3 0.5 1.0 CB B:CYS460 3.5 80.1 1.0 N B:CYS457 3.6 0.4 1.0 N B:CYS434 3.9 0.9 1.0 CA B:CYS434 4.0 0.6 1.0 CA B:CYS457 4.0 0.3 1.0 OG B:SER436 4.0 0.7 1.0 N B:CYS460 4.1 98.7 1.0 CB B:SER436 4.1 0.4 1.0 O B:CYS434 4.2 0.3 1.0 C B:CYS434 4.3 0.4 1.0 CA B:CYS460 4.4 87.0 1.0 O B:CYS457 4.4 0.5 1.0 CA B:CYS431 4.4 1.0 1.0 C B:CYS457 4.6 0.3 1.0 N B:SER436 4.7 0.5 1.0 C B:LEU456 4.7 0.3 1.0 C B:ALA433 4.8 0.0 1.0 CB B:ARG459 4.9 72.6 1.0

A.Alt, E.J.Mancini. Structure of CHD5 PHD2 - Tandem Chromodomains To Be Published.