Zinc in PDB 5yz9: Zinc Finger Domain of METTL3-METTL14 N6-Methyladenosine Methyltransferase

All present enzymatic activity of Zinc Finger Domain of METTL3-METTL14 N6-Methyladenosine Methyltransferase:
2.1.1.62;

The binding sites of Zinc atom in the Zinc Finger Domain of METTL3-METTL14 N6-Methyladenosine Methyltransferase (pdb code 5yz9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Zinc Finger Domain of METTL3-METTL14 N6-Methyladenosine Methyltransferase, PDB code: 5yz9:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Zinc Finger Domain of METTL3-METTL14 N6-Methyladenosine Methyltransferase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Zinc Finger Domain of METTL3-METTL14 N6-Methyladenosine Methyltransferase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn801 b:0.0 occ:1.00 NE2 A:HIS298 2.2 0.0 1.0 SG A:CYS284 2.3 0.0 1.0 SG A:CYS276 2.4 0.0 1.0 SG A:CYS294 2.4 0.0 1.0 HD2 A:HIS298 2.6 0.0 1.0 CD2 A:HIS298 2.7 0.0 1.0 HB2 A:CYS276 2.9 0.0 1.0 CB A:CYS276 3.0 0.0 1.0 HB3 A:CYS276 3.1 0.0 1.0 CE1 A:HIS298 3.4 0.0 1.0 H A:ASP277 3.4 0.0 1.0 CB A:CYS284 3.8 0.0 1.0 HB2 A:CYS284 3.8 0.0 1.0 CB A:CYS294 3.9 0.0 1.0 HE1 A:HIS298 3.9 0.0 1.0 HB2 A:CYS294 4.0 0.0 1.0 CG A:HIS298 4.0 0.0 1.0 HE1 A:TYR278 4.1 0.0 1.0 H A:ARG295 4.2 0.0 1.0 ND1 A:HIS298 4.3 0.0 1.0 HB3 A:CYS284 4.4 0.0 1.0 N A:ASP277 4.4 0.0 1.0 HG2 A:ARG295 4.4 0.0 1.0 HA A:CYS294 4.4 0.0 1.0 CE1 A:TYR278 4.4 0.0 1.0 CA A:CYS276 4.5 0.0 1.0 H A:TYR278 4.5 0.0 1.0 HB3 A:CYS294 4.6 0.0 1.0 HB3 A:ASP277 4.7 0.0 1.0 CA A:CYS294 4.8 0.0 1.0 HD1 A:TYR278 4.8 0.0 1.0 HA A:CYS284 4.8 0.0 1.0 CD1 A:TYR278 4.8 0.0 1.0 H A:CYS276 4.8 0.0 1.0 CA A:CYS284 4.9 0.0 1.0 HA A:SER288 4.9 0.0 1.0 H A:GLY279 4.9 0.0 1.0 C A:CYS276 5.0 0.0 1.0

Zinc binding site 2 out of 2 in the Zinc Finger Domain of METTL3-METTL14 N6-Methyladenosine Methyltransferase


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Zinc Finger Domain of METTL3-METTL14 N6-Methyladenosine Methyltransferase within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn802 b:0.0 occ:1.00 NE2 A:HIS330 2.2 0.0 1.0 SG A:CYS320 2.4 0.0 1.0 SG A:CYS314 2.4 0.0 1.0 SG A:CYS326 2.4 0.0 1.0 HA A:CYS326 2.7 0.0 1.0 HB3 A:CYS314 3.0 0.0 1.0 CE1 A:HIS330 3.0 0.0 1.0 HE1 A:HIS330 3.2 0.0 1.0 H A:CYS326 3.2 0.0 1.0 CD2 A:HIS330 3.3 0.0 1.0 CB A:CYS314 3.3 0.0 1.0 CA A:CYS326 3.4 0.0 1.0 CB A:CYS326 3.4 0.0 1.0 HD2 A:HIS330 3.6 0.0 1.0 N A:CYS326 3.7 0.0 1.0 HG21 A:THR325 3.8 0.0 1.0 HB3 A:CYS326 3.9 0.0 1.0 HA A:CYS314 3.9 0.0 1.0 CB A:CYS320 4.0 0.0 1.0 HB2 A:CYS314 4.1 0.0 1.0 HB3 A:CYS320 4.1 0.0 1.0 CA A:CYS314 4.2 0.0 1.0 ND1 A:HIS330 4.3 0.0 1.0 HA A:MET323 4.3 0.0 1.0 HB2 A:CYS326 4.3 0.0 1.0 HG23 A:THR325 4.3 0.0 1.0 HA A:CYS320 4.4 0.0 1.0 CG A:HIS330 4.4 0.0 1.0 CG2 A:THR325 4.5 0.0 1.0 O A:HIS322 4.6 0.0 1.0 HB2 A:CYS320 4.7 0.0 1.0 HB3 A:PHE316 4.7 0.0 1.0 CA A:CYS320 4.7 0.0 1.0 O A:CYS320 4.8 0.0 1.0 C A:CYS326 4.8 0.0 1.0 C A:THR325 4.9 0.0 1.0

J.Huang, X.Dong, Z.Gong, L.Y.Qin, S.Yang, Y.L.Zhu, X.Wang, D.Zhang, T.Zou, P.Yin, C.Tang. Solution Structure of the Rna Recognition Domain of METTL3-METTL14 N6-Methyladenosine Methyltransferase. Protein Cell V. 10 272 2019.
ISSN: ESSN 1674-8018
PubMed: 29542011
DOI: 10.1007/S13238-018-0518-7