Zinc in PDB 2rpc: Solution Structure of the Tandem Zf-C2H2 Domains From the Human Zinc Finger Protein Zic 3

The binding sites of Zinc atom in the Solution Structure of the Tandem Zf-C2H2 Domains From the Human Zinc Finger Protein Zic 3 (pdb code 2rpc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Solution Structure of the Tandem Zf-C2H2 Domains From the Human Zinc Finger Protein Zic 3, PDB code: 2rpc:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Solution Structure of the Tandem Zf-C2H2 Domains From the Human Zinc Finger Protein Zic 3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Solution Structure of the Tandem Zf-C2H2 Domains From the Human Zinc Finger Protein Zic 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:0.0 occ:1.00 NE2 A:HIS49 2.0 0.0 1.0 NE2 A:HIS44 2.1 0.0 1.0 SG A:CYS16 2.2 0.0 1.0 SG A:CYS31 2.4 0.0 1.0 CD2 A:HIS49 2.6 0.0 1.0 HD2 A:HIS49 2.8 0.0 1.0 CD2 A:HIS44 2.9 0.0 1.0 CE1 A:HIS49 3.0 0.0 1.0 HD2 A:HIS44 3.0 0.0 1.0 CE1 A:HIS44 3.2 0.0 1.0 HB3 A:CYS31 3.4 0.0 1.0 HB2 A:CYS16 3.4 0.0 1.0 HE1 A:HIS49 3.5 0.0 1.0 CB A:CYS31 3.5 0.0 1.0 CB A:CYS16 3.5 0.0 1.0 HE1 A:HIS44 3.6 0.0 1.0 O A:CYS16 3.7 0.0 1.0 CG A:HIS49 3.7 0.0 1.0 HB2 A:CYS31 3.7 0.0 1.0 HB2 A:TRP18 3.8 0.0 1.0 ND1 A:HIS49 3.8 0.0 1.0 HZ A:PHE35 3.9 0.0 1.0 HG22 A:VAL45 4.1 0.0 1.0 HB3 A:ARG33 4.1 0.0 1.0 CG A:HIS44 4.1 0.0 1.0 HB3 A:CYS16 4.2 0.0 1.0 HA A:VAL45 4.2 0.0 1.0 ND1 A:HIS44 4.3 0.0 1.0 HG23 A:VAL45 4.4 0.0 1.0 HD3 A:ARG33 4.4 0.0 1.0 C A:CYS16 4.5 0.0 1.0 HB3 A:TRP18 4.6 0.0 1.0 CA A:CYS16 4.6 0.0 1.0 HE3 A:TRP18 4.7 0.0 1.0 CB A:TRP18 4.7 0.0 1.0 HD1 A:HIS49 4.7 0.0 1.0 CG2 A:VAL45 4.8 0.0 1.0 H A:CYS16 4.8 0.0 1.0 CA A:CYS31 4.9 0.0 1.0 O A:CYS31 4.9 0.0 1.0 HB2 A:ARG33 4.9 0.0 1.0 HE1 A:PHE35 4.9 0.0 1.0 CZ A:PHE35 4.9 0.0 1.0 HB2 A:HIS49 5.0 0.0 1.0 CB A:HIS49 5.0 0.0 1.0 H A:TRP18 5.0 0.0 1.0 CB A:ARG33 5.0 0.0 1.0

Zinc binding site 2 out of 4 in the Solution Structure of the Tandem Zf-C2H2 Domains From the Human Zinc Finger Protein Zic 3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Solution Structure of the Tandem Zf-C2H2 Domains From the Human Zinc Finger Protein Zic 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:0.0 occ:1.00 NE2 A:HIS85 2.1 0.0 1.0 NE2 A:HIS81 2.1 0.0 1.0 SG A:CYS60 2.1 0.0 1.0 SG A:CYS65 2.1 0.0 1.0 HB2 A:TRP62 2.9 0.0 1.0 CE1 A:HIS81 2.9 0.0 1.0 HE1 A:HIS81 3.0 0.0 1.0 CE1 A:HIS85 3.1 0.0 1.0 CD2 A:HIS85 3.1 0.0 1.0 CD2 A:HIS81 3.3 0.0 1.0 HE1 A:HIS85 3.3 0.0 1.0 HD2 A:HIS85 3.3 0.0 1.0 HB2 A:CYS65 3.5 0.0 1.0 HB3 A:CYS60 3.5 0.0 1.0 CB A:CYS65 3.5 0.0 1.0 O A:CYS60 3.5 0.0 1.0 CB A:CYS60 3.5 0.0 1.0 HD2 A:HIS81 3.6 0.0 1.0 HE3 A:TRP62 3.8 0.0 1.0 H A:TRP62 3.8 0.0 1.0 CB A:TRP62 3.9 0.0 1.0 HD2 A:PRO66 4.0 0.0 1.0 C A:CYS60 4.1 0.0 1.0 ND1 A:HIS81 4.1 0.0 1.0 ND1 A:HIS85 4.2 0.0 1.0 HB3 A:CYS65 4.2 0.0 1.0 CG A:HIS85 4.2 0.0 1.0 HA A:CYS65 4.2 0.0 1.0 HB3 A:TRP62 4.3 0.0 1.0 HB2 A:CYS60 4.3 0.0 1.0 CG A:HIS81 4.3 0.0 1.0 N A:TRP62 4.4 0.0 1.0 CA A:CYS60 4.5 0.0 1.0 CE3 A:TRP62 4.5 0.0 1.0 CA A:CYS65 4.5 0.0 1.0 HG12 A:ILE82 4.6 0.0 1.0 HA A:ILE82 4.6 0.0 1.0 CG A:TRP62 4.7 0.0 1.0 HB2 A:ARG67 4.7 0.0 1.0 CA A:TRP62 4.8 0.0 1.0 CD2 A:TRP62 4.8 0.0 1.0 HG3 A:ARG67 4.9 0.0 1.0 HG2 A:ARG67 4.9 0.0 1.0 N A:TYR61 4.9 0.0 1.0 HD1 A:HIS81 4.9 0.0 1.0 H A:ARG67 5.0 0.0 1.0

Zinc binding site 3 out of 4 in the Solution Structure of the Tandem Zf-C2H2 Domains From the Human Zinc Finger Protein Zic 3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Solution Structure of the Tandem Zf-C2H2 Domains From the Human Zinc Finger Protein Zic 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:0.0 occ:1.00 NE2 A:HIS111 2.1 0.0 1.0 NE2 A:HIS115 2.1 0.0 1.0 SG A:CYS93 2.2 0.0 1.0 SG A:CYS98 2.4 0.0 1.0 CE1 A:HIS115 3.0 0.0 1.0 HB3 A:LYS100 3.0 0.0 1.0 CD2 A:HIS111 3.1 0.0 1.0 CE1 A:HIS111 3.1 0.0 1.0 HE1 A:HIS115 3.1 0.0 1.0 CD2 A:HIS115 3.2 0.0 1.0 HB3 A:CYS98 3.2 0.0 1.0 CB A:CYS98 3.3 0.0 1.0 HD2 A:HIS111 3.3 0.0 1.0 HE1 A:HIS111 3.3 0.0 1.0 HB3 A:PHE95 3.3 0.0 1.0 HB2 A:CYS98 3.4 0.0 1.0 HB2 A:PHE95 3.5 0.0 1.0 HD2 A:HIS115 3.5 0.0 1.0 CB A:CYS93 3.5 0.0 1.0 HB2 A:CYS93 3.5 0.0 1.0 HB3 A:CYS93 3.8 0.0 1.0 CB A:PHE95 3.9 0.0 1.0 HE1 A:PHE102 4.0 0.0 1.0 HZ A:PHE102 4.0 0.0 1.0 CB A:LYS100 4.1 0.0 1.0 HG2 A:LYS100 4.1 0.0 1.0 ND1 A:HIS115 4.1 0.0 1.0 ND1 A:HIS111 4.2 0.0 1.0 CG A:HIS111 4.2 0.0 1.0 H A:LYS100 4.2 0.0 1.0 CG A:HIS115 4.3 0.0 1.0 H A:PHE95 4.3 0.0 1.0 HB2 A:LYS100 4.4 0.0 1.0 HD2 A:PRO94 4.4 0.0 1.0 CG A:LYS100 4.6 0.0 1.0 CA A:CYS98 4.7 0.0 1.0 CG A:PHE95 4.7 0.0 1.0 CE1 A:PHE102 4.8 0.0 1.0 HA A:LYS112 4.8 0.0 1.0 CZ A:PHE102 4.8 0.0 1.0 CA A:CYS93 4.8 0.0 1.0 HD2 A:PHE95 4.8 0.0 1.0 HG3 A:LYS100 4.9 0.0 1.0 HA A:CYS93 5.0 0.0 1.0 HD12 A:LEU108 5.0 0.0 1.0 N A:PHE95 5.0 0.0 1.0 N A:LYS100 5.0 0.0 1.0

Zinc binding site 4 out of 4 in the Solution Structure of the Tandem Zf-C2H2 Domains From the Human Zinc Finger Protein Zic 3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Solution Structure of the Tandem Zf-C2H2 Domains From the Human Zinc Finger Protein Zic 3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn801 b:0.0 occ:1.00 NE2 A:HIS141 2.1 0.0 1.0 NE2 A:HIS145 2.1 0.0 1.0 SG A:CYS123 2.2 0.0 1.0 SG A:CYS128 2.3 0.0 1.0 HD2 A:HIS141 2.6 0.0 1.0 CD2 A:HIS141 2.6 0.0 1.0 HG3 A:ARG130 3.0 0.0 1.0 CE1 A:HIS145 3.0 0.0 1.0 HB3 A:PHE125 3.0 0.0 1.0 HE1 A:HIS145 3.1 0.0 1.0 CD2 A:HIS145 3.2 0.0 1.0 HB3 A:CYS128 3.2 0.0 1.0 CB A:CYS128 3.3 0.0 1.0 CE1 A:HIS141 3.3 0.0 1.0 HB2 A:PHE125 3.4 0.0 1.0 HD2 A:HIS145 3.5 0.0 1.0 HE3 A:MET142 3.5 0.0 1.0 CB A:CYS123 3.5 0.0 1.0 HB2 A:CYS128 3.5 0.0 1.0 HB2 A:CYS123 3.6 0.0 1.0 HG2 A:ARG130 3.7 0.0 1.0 CB A:PHE125 3.7 0.0 1.0 HB3 A:CYS123 3.7 0.0 1.0 CG A:ARG130 3.8 0.0 1.0 HE1 A:HIS141 3.8 0.0 1.0 CG A:HIS141 3.9 0.0 1.0 ND1 A:HIS145 4.1 0.0 1.0 CE A:MET142 4.2 0.0 1.0 HE1 A:MET142 4.2 0.0 1.0 ND1 A:HIS141 4.2 0.0 1.0 HE2 A:MET142 4.2 0.0 1.0 CG A:HIS145 4.3 0.0 1.0 H A:PHE125 4.3 0.0 1.0 CG A:PHE125 4.4 0.0 1.0 HB2 A:ARG130 4.4 0.0 1.0 HD2 A:PHE125 4.5 0.0 1.0 HD3 A:ARG130 4.7 0.0 1.0 CA A:CYS128 4.7 0.0 1.0 HZ A:PHE132 4.7 0.0 1.0 CB A:ARG130 4.7 0.0 1.0 CD2 A:PHE125 4.8 0.0 1.0 O A:HIS141 4.8 0.0 1.0 CD A:ARG130 4.8 0.0 1.0 CA A:PHE125 4.9 0.0 1.0 CA A:CYS123 4.9 0.0 1.0 HE2 A:PHE132 4.9 0.0 1.0 O A:PHE125 4.9 0.0 1.0 N A:PHE125 5.0 0.0 1.0 HE A:ARG130 5.0 0.0 1.0 HD1 A:HIS145 5.0 0.0 1.0

M.Hatayama, T.Tomizawa, K.Sakai-Kato, P.Bouvagnet, S.Kose, N.Imamoto, S.Yokoyama, N.Utsunomiya-Tate, K.Mikoshiba, T.Kigawa, J.Aruga. Functional and Structural Basis of the Nuclear Localization Signal in the ZIC3 Zinc Finger Domain Hum.Mol.Genet. V. 17 3459 2008.
ISSN: ISSN 0964-6906
PubMed: 18716025
DOI: 10.1093/HMG/DDN239