Zinc in PDB 1r33: Golgi Alpha-Mannosidase II Complex with 5-Thio-D-Mannopyranosylamine

All present enzymatic activity of Golgi Alpha-Mannosidase II Complex with 5-Thio-D-Mannopyranosylamine:
3.2.1.114;

The structure of Golgi Alpha-Mannosidase II Complex with 5-Thio-D-Mannopyranosylamine, PDB code: 1r33 was solved by D.A.Kuntz, W.Xin, L.M.Kavelekar, D.R.Rose, B.M.Pinto, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.86 / 1.80
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	68.838, 109.911, 138.891, 90.00, 90.00, 90.00
R / Rfree (%)	15.6 / 18.5

The binding sites of Zinc atom in the Golgi Alpha-Mannosidase II Complex with 5-Thio-D-Mannopyranosylamine (pdb code 1r33). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Golgi Alpha-Mannosidase II Complex with 5-Thio-D-Mannopyranosylamine, PDB code: 1r33:

Zinc binding site 1 out of 1 in the Golgi Alpha-Mannosidase II Complex with 5-Thio-D-Mannopyranosylamine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Golgi Alpha-Mannosidase II Complex with 5-Thio-D-Mannopyranosylamine within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1163 b:11.1 occ:1.00 NE2 A:HIS90 2.1 5.8 1.0 NE2 A:HIS471 2.1 8.8 1.0 OD1 A:ASP204 2.2 6.8 1.0 OD1 A:ASP92 2.2 9.0 1.0 O3 A:LKA1162 2.2 8.9 1.0 O2 A:LKA1162 2.2 10.3 1.0 C2 A:LKA1162 3.0 11.5 1.0 CD2 A:HIS471 3.0 8.6 1.0 CD2 A:HIS90 3.0 6.9 1.0 CG A:ASP92 3.1 8.4 1.0 C3 A:LKA1162 3.2 10.0 1.0 CE1 A:HIS90 3.2 6.0 1.0 CG A:ASP204 3.2 8.5 1.0 CE1 A:HIS471 3.2 7.6 1.0 OD2 A:ASP92 3.4 11.4 1.0 CB A:ASP204 3.7 7.6 1.0 C1 A:LKA1162 3.9 12.8 1.0 OD2 A:ASP472 4.0 8.8 1.0 C4 A:LKA1162 4.0 10.5 1.0 CG A:HIS471 4.2 6.9 1.0 CG A:HIS90 4.2 5.8 1.0 ND1 A:HIS90 4.3 7.6 1.0 ND1 A:HIS471 4.3 7.2 1.0 OD2 A:ASP204 4.3 8.5 1.0 N1 A:LKA1162 4.3 14.8 1.0 CE1 A:HIS470 4.4 8.3 1.0 CB A:ASP92 4.5 7.4 1.0 O A:HOH1762 4.6 9.7 1.0 OH A:TYR269 4.6 11.4 1.0 O4 A:LKA1162 4.9 9.2 1.0 CG A:ASP472 5.0 8.1 1.0 CA A:ASP92 5.0 8.3 1.0

L.M.Kavelekar, D.A.Kuntz, W.Xin, B.D.Johnston, B.Svensson, D.R.Rose, B.M.Pinto. 5-Thio-D-Glycopyranosylamines and Their Amidinium Salts As Potential Transition-State Mimics of Glycosyl Hydrolases: Synthesis, Enzyme Inhibitory Activities, X-Ray Crystallography, and Molecular Modeling Tetrahedron Asymmetry V. 16 1035 2005.
ISSN: ISSN 0957-4166
DOI: 10.1016/J.TETASY.2005.01.021