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Atomistry » Zinc » PDB 4jsg-4k4s » 4jsr » |
Zinc in PDB 4jsr: Crystal Structure of Human SIRT3 with Elt Inhibitor 11C [N-{2-[1-(6- Carbamoylthieno[3,2-D]Pyrimidin-4-Yl)Piperidin-4-Yl]Ethyl}-N'- Ethylthiophene-2,5-Dicarboxamide]Protein crystallography data
The structure of Crystal Structure of Human SIRT3 with Elt Inhibitor 11C [N-{2-[1-(6- Carbamoylthieno[3,2-D]Pyrimidin-4-Yl)Piperidin-4-Yl]Ethyl}-N'- Ethylthiophene-2,5-Dicarboxamide], PDB code: 4jsr
was solved by
H.Dai,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human SIRT3 with Elt Inhibitor 11C [N-{2-[1-(6- Carbamoylthieno[3,2-D]Pyrimidin-4-Yl)Piperidin-4-Yl]Ethyl}-N'- Ethylthiophene-2,5-Dicarboxamide]
(pdb code 4jsr). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human SIRT3 with Elt Inhibitor 11C [N-{2-[1-(6- Carbamoylthieno[3,2-D]Pyrimidin-4-Yl)Piperidin-4-Yl]Ethyl}-N'- Ethylthiophene-2,5-Dicarboxamide], PDB code: 4jsr: Zinc binding site 1 out of 1 in 4jsrGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Crystal Structure of Human SIRT3 with Elt Inhibitor 11C [N-{2-[1-(6- Carbamoylthieno[3,2-D]Pyrimidin-4-Yl)Piperidin-4-Yl]Ethyl}-N'- Ethylthiophene-2,5-Dicarboxamide]
![]() Mono view ![]() Stereo pair view
Reference:
J.S.Disch,
G.Evindar,
C.H.Chiu,
C.A.Blum,
H.Dai,
L.Jin,
E.Schuman,
K.E.Lind,
S.L.Belyanskaya,
J.Deng,
F.Coppo,
L.Aquilani,
T.L.Graybill,
J.W.Cuozzo,
S.Lavu,
C.Mao,
G.P.Vlasuk,
R.B.Perni.
Discovery of Thieno[3,2-D]Pyrimidine-6-Carboxamides As Potent Inhibitors of SIRT1, SIRT2, and SIRT3. J.Med.Chem. V. 56 3666 2013.
Page generated: Sun Oct 27 01:29:37 2024
ISSN: ISSN 0022-2623 PubMed: 23570514 DOI: 10.1021/JM400204K |
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