Zinc in PDB 9fzk: Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14

All present enzymatic activity of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14:
2.1.1.56;

The structure of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14, PDB code: 9fzk was solved by S.Z.Fisher, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.24 / 1.30
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	43.935, 100.086, 51.231, 90, 114.59, 90
R / Rfree (%)	16.1 / 18.5

The binding sites of Zinc atom in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14 (pdb code 9fzk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14, PDB code: 9fzk:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:13.8 occ:1.00 NE2 A:HIS83 2.0 13.4 1.0 SG A:CYS77 2.3 13.5 1.0 SG A:CYS74 2.3 13.2 1.0 SG A:CYS90 2.3 14.2 1.0 CE1 A:HIS83 3.0 13.4 1.0 CD2 A:HIS83 3.1 13.2 1.0 CB A:CYS74 3.1 12.2 1.0 CB A:CYS90 3.2 15.2 1.0 CB A:CYS77 3.5 11.5 1.0 N A:CYS77 3.5 12.5 1.0 CA A:CYS77 4.0 13.0 1.0 ND1 A:HIS83 4.2 13.9 1.0 CG A:HIS83 4.2 12.7 1.0 O A:HOH512 4.3 28.7 1.0 CA A:CYS90 4.4 15.9 1.0 O A:HOH393 4.4 19.7 1.0 C A:TYR76 4.4 12.5 1.0 CB A:TYR76 4.5 13.2 1.0 CA A:CYS74 4.5 12.2 1.0 CB A:LYS93 4.8 13.8 1.0 CA A:TYR76 4.8 12.8 1.0 O A:CYS74 4.8 11.5 1.0 C A:CYS74 4.9 11.6 1.0 N A:LYS93 4.9 13.2 1.0 N A:TYR76 4.9 12.8 1.0

Zinc binding site 2 out of 4 in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:19.0 occ:1.00 SG A:CYS130 2.3 21.1 1.0 SG A:CYS120 2.3 17.6 1.0 SG A:CYS128 2.3 19.3 1.0 SG A:CYS117 2.3 17.8 1.0 CB A:CYS117 3.1 15.7 1.0 CB A:CYS130 3.3 21.8 1.0 CB A:CYS120 3.4 19.9 1.0 CB A:CYS128 3.5 19.4 1.0 N A:CYS130 3.7 24.1 1.0 N A:CYS120 3.8 17.8 1.0 N A:SER129 3.9 21.4 1.0 CA A:CYS128 3.9 18.8 1.0 NZ A:LYS124 4.1 27.5 1.0 CA A:CYS130 4.1 23.1 1.0 CA A:CYS120 4.1 18.7 1.0 C A:CYS128 4.2 22.8 1.0 O A:HOH455 4.4 31.9 1.0 CA A:CYS117 4.6 16.0 1.0 CB A:VAL119 4.6 20.8 1.0 C A:SER129 4.6 27.4 1.0 OG A:SER129 4.7 23.6 1.0 CA A:SER129 4.8 23.2 1.0 C A:VAL119 4.8 20.1 1.0 C A:CYS120 4.9 18.1 1.0

Zinc binding site 3 out of 4 in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn301 b:17.8 occ:1.00 ND1 B:HIS264 2.1 19.9 1.0 NE2 B:HIS257 2.1 17.3 1.0 SG B:CYS261 2.2 20.7 1.0 SG B:CYS279 2.3 17.1 1.0 CE1 B:HIS264 3.0 20.2 1.0 CE1 B:HIS257 3.0 17.8 1.0 CB B:CYS261 3.1 19.6 1.0 CG B:HIS264 3.1 19.9 1.0 CD2 B:HIS257 3.1 16.0 1.0 CB B:CYS279 3.3 12.8 1.0 CB B:HIS264 3.4 26.0 1.0 O B:HOH696 4.0 31.8 1.0 NE2 B:HIS264 4.1 21.8 1.0 ND1 B:HIS257 4.1 18.4 1.0 CD2 B:HIS264 4.2 22.9 1.0 CG B:HIS257 4.2 16.1 1.0 O B:HOH624 4.4 18.6 1.0 N B:HIS264 4.5 28.4 1.0 CA B:CYS261 4.5 21.4 1.0 CA B:HIS264 4.6 27.1 1.0 CG2 B:VAL263 4.6 33.5 1.0 CA B:CYS279 4.7 15.1 1.0 CE1 B:HIS283 4.8 25.8 1.0 C B:CYS261 4.9 27.9 1.0 O B:HOH453 5.0 35.8 1.0

Zinc binding site 4 out of 4 in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn302 b:25.0 occ:1.00 ND1 B:HIS229 2.0 29.1 1.0 SG B:CYS207 2.3 23.6 1.0 SG B:CYS226 2.3 21.6 1.0 SG B:CYS210 2.3 28.7 1.0 CE1 B:HIS229 2.9 27.9 1.0 CB B:CYS207 3.0 17.5 1.0 CG B:HIS229 3.1 23.7 1.0 CB B:CYS226 3.5 21.5 1.0 CB B:HIS229 3.6 23.5 1.0 CB B:CYS210 3.6 27.9 1.0 N B:CYS210 3.8 33.0 1.0 N B:CYS226 4.0 18.3 1.0 NE2 B:HIS229 4.1 26.8 1.0 CD2 B:HIS229 4.2 31.8 1.0 CA B:CYS210 4.3 32.5 1.0 C B:LEU209 4.3 33.7 1.0 CA B:CYS226 4.3 16.4 1.0 N B:HIS229 4.4 19.6 1.0 NH1 B:ARG212 4.4 30.9 1.0 CA B:CYS207 4.5 23.2 1.0 CB B:LEU209 4.6 30.9 1.0 CA B:HIS229 4.6 21.9 1.0 N B:LEU209 4.7 32.9 1.0 C B:CYS210 4.7 31.4 1.0 CA B:LEU209 4.7 33.0 1.0 CB B:HIS228 4.8 21.2 1.0 CD B:ARG212 4.8 27.0 1.0 CB B:ARG212 4.8 25.3 1.0 C B:CYS226 4.9 16.1 1.0 O B:CYS210 4.9 36.9 1.0 O B:LEU209 4.9 38.8 1.0

S.Z.Fisher, S.Z.Fisher. N/A N/A.