Zinc in PDB 9fz4: Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14

All present enzymatic activity of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14:
2.1.1.56;

The structure of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14, PDB code: 9fz4 was solved by S.Z.Fisher, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	53.94 / 2.44
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	62.034, 70.724, 109.205, 90, 90, 90
R / Rfree (%)	18.2 / 22.9

The structure of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14 also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Zinc atom in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14 (pdb code 9fz4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14, PDB code: 9fz4:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn201 b:34.2 occ:1.00 SG A:CYS74 1.9 45.7 1.0 SG A:CYS77 2.0 34.7 1.0 NE2 A:HIS83 2.1 34.0 1.0 SG A:CYS90 2.3 31.3 1.0 CB A:CYS74 2.5 28.2 1.0 CD2 A:HIS83 3.1 31.1 1.0 CB A:CYS90 3.1 31.5 1.0 CE1 A:HIS83 3.2 38.3 1.0 CB A:CYS77 3.3 29.8 1.0 N A:CYS77 3.5 26.8 1.0 CA A:CYS77 3.9 32.7 1.0 CA A:CYS74 3.9 37.9 1.0 O A:HOH323 4.1 45.1 1.0 CG A:HIS83 4.3 32.4 1.0 ND1 A:HIS83 4.3 38.7 1.0 C A:TYR76 4.3 33.7 1.0 CA A:CYS90 4.3 36.7 1.0 CB A:TYR76 4.4 29.1 1.0 C A:CYS74 4.4 29.5 1.0 O A:CYS74 4.6 31.2 1.0 O A:HOH360 4.6 34.7 1.0 CA A:TYR76 4.6 28.6 1.0 CB A:LYS93 4.8 33.1 1.0 N A:TYR76 4.8 28.4 1.0 N A:CYS74 5.0 28.9 1.0 N A:LYS93 5.0 26.4 1.0

Zinc binding site 2 out of 4 in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn202 b:58.5 occ:1.00 SG A:CYS128 2.2 54.9 1.0 SG A:CYS117 2.4 58.6 1.0 SG A:CYS130 2.4 82.1 1.0 SG A:CYS120 2.4 52.2 1.0 CB A:CYS117 3.1 47.5 1.0 CB A:CYS130 3.2 78.8 1.0 CB A:CYS128 3.4 53.7 1.0 CB A:CYS120 3.5 46.3 1.0 N A:CYS130 3.9 76.8 1.0 N A:CYS120 3.9 57.5 1.0 CA A:CYS128 4.0 60.6 1.0 CA A:CYS130 4.2 87.3 1.0 CA A:CYS120 4.3 55.1 1.0 N A:SER129 4.4 85.1 1.0 C A:CYS128 4.5 69.5 1.0 CA A:CYS117 4.5 45.4 1.0 CB A:VAL119 4.7 69.4 1.0

Zinc binding site 3 out of 4 in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn301 b:49.7 occ:1.00 SG B:CYS210 2.0 81.9 1.0 ND1 B:HIS229 2.0 53.4 1.0 SG B:CYS226 2.3 50.0 1.0 SG B:CYS207 2.3 45.8 1.0 CE1 B:HIS229 2.9 49.7 1.0 CG B:HIS229 3.1 48.8 1.0 CB B:CYS210 3.2 54.9 1.0 CB B:CYS207 3.3 47.9 1.0 CB B:HIS229 3.5 45.8 1.0 CB B:CYS226 3.5 41.5 1.0 N B:CYS210 3.9 53.7 1.0 NE2 B:HIS229 4.0 51.6 1.0 N B:CYS226 4.1 39.8 1.0 CD2 B:HIS229 4.1 45.4 1.0 CA B:CYS210 4.2 55.2 1.0 NH1 B:ARG212 4.2 53.5 1.0 C B:LEU209 4.2 58.8 1.0 N B:HIS229 4.3 45.3 1.0 CA B:CYS226 4.4 31.9 1.0 CB B:LEU209 4.5 43.0 1.0 CB B:HIS228 4.6 41.6 1.0 CA B:HIS229 4.6 45.4 1.0 O B:LEU209 4.6 59.7 1.0 CA B:LEU209 4.7 53.7 1.0 CA B:CYS207 4.7 55.2 1.0 N B:LEU209 4.7 52.4 1.0 CD B:ARG212 4.8 42.6 1.0 CB B:ARG212 4.9 44.2 1.0 C B:CYS226 4.9 36.1 1.0 C B:CYS210 5.0 53.4 1.0 C B:HIS228 5.0 48.1 1.0

Zinc binding site 4 out of 4 in the Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Sars Cov-2 NSP10 in Complex with Theexon Domain From NSP14 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn302 b:30.3 occ:1.00 NE2 B:HIS257 2.1 38.7 1.0 ND1 B:HIS264 2.1 28.5 1.0 SG B:CYS261 2.3 30.7 1.0 SG B:CYS279 2.3 26.6 1.0 CE1 B:HIS264 3.0 28.4 1.0 CB B:CYS261 3.0 33.8 1.0 CE1 B:HIS257 3.0 38.0 1.0 CD2 B:HIS257 3.0 33.6 1.0 CG B:HIS264 3.1 34.1 1.0 CB B:CYS279 3.3 29.6 1.0 CB B:HIS264 3.5 35.5 1.0 O B:HOH523 3.9 32.6 1.0 O B:HOH528 4.0 34.0 1.0 ND1 B:HIS257 4.1 35.0 1.0 NE2 B:HIS264 4.1 23.6 1.0 CG B:HIS257 4.1 35.5 1.0 CD2 B:HIS264 4.2 27.2 1.0 O B:HOH489 4.3 29.7 1.0 CA B:CYS261 4.5 32.4 1.0 N B:HIS264 4.6 35.1 1.0 CA B:HIS264 4.7 38.1 1.0 CA B:CYS279 4.8 32.3 1.0 CG2 B:VAL263 4.9 33.0 1.0 CE1 B:HIS283 4.9 32.6 1.0 C B:CYS261 4.9 33.8 1.0

S.Z.Fisher, S.Z.Fisher. N/A N/A.