Zinc in PDB 9cxj: Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region

All present enzymatic activity of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region:
3.1.4.35;

The structure of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region (pdb code 9cxj). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region, PDB code: 9cxj:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn901 b:105.5 occ:1.00 OD2 A:ASP603 2.0 69.0 1.0 OD1 A:ASP723 2.0 66.0 1.0 NE2 A:HIS566 2.0 65.5 1.0 NE2 A:HIS602 2.0 46.4 1.0 CE1 A:HIS566 2.6 62.3 1.0 CD2 A:HIS602 2.7 43.2 1.0 CG A:ASP723 3.1 64.9 1.0 MG A:MG902 3.1 49.3 1.0 CE1 A:HIS602 3.2 45.3 1.0 CG A:ASP603 3.2 62.4 1.0 CD2 A:HIS566 3.3 53.5 1.0 OD2 A:ASP723 3.6 72.0 1.0 ND1 A:HIS566 3.8 55.3 1.0 CG A:HIS602 3.9 50.3 1.0 OD1 A:ASP603 3.9 65.6 1.0 ND1 A:HIS602 4.1 51.1 1.0 CB A:ASP603 4.2 43.5 1.0 CG A:HIS566 4.2 47.7 1.0 CG2 A:VAL570 4.3 49.4 1.0 CB A:ASP723 4.4 51.8 1.0 CA A:ASP723 4.6 54.5 1.0 O A:ASP723 4.8 69.4 1.0

Zinc binding site 2 out of 2 in the Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of PDE6C in Complex with the Rod Inhibitory P Gamma Subunit with Disordered Gafa Region within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn901 b:116.1 occ:1.00 OD1 B:ASP723 2.0 79.9 1.0 OD2 B:ASP603 2.0 68.9 1.0 OD2 B:ASP723 2.0 78.0 1.0 NE2 B:HIS602 2.0 45.1 1.0 NE2 B:HIS566 2.1 67.8 1.0 CG B:ASP723 2.2 72.3 1.0 CD2 B:HIS602 2.6 41.7 1.0 CE1 B:HIS566 3.0 63.7 1.0 CD2 B:HIS566 3.1 57.8 1.0 CG B:ASP603 3.1 63.8 1.0 CE1 B:HIS602 3.3 46.8 1.0 CB B:ASP723 3.7 56.0 1.0 OD1 B:ASP603 3.7 65.3 1.0 MG B:MG902 3.7 41.1 1.0 CG B:HIS602 3.9 48.9 1.0 ND1 B:HIS566 4.1 57.2 1.0 ND1 B:HIS602 4.1 48.8 1.0 CG B:HIS566 4.2 48.7 1.0 CB B:ASP603 4.3 44.1 1.0 CA B:ASP723 4.4 59.3 1.0 CG2 B:VAL570 4.5 47.7 1.0 O B:ASP723 4.8 77.2 1.0 CD2 B:HIS562 4.8 59.9 1.0

S.Singh, D.Srivastava, K.Boyd, N.Artemyev. Structural and Functional Dynamics of Human Cone Cgmp-Phosphodiesterase Important For Photopic Vision Proc.Natl.Acad.Sci.Usa 2025.
ISSN: ESSN 1091-6490