Zinc in PDB 9c8u: Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min

All present enzymatic activity of Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min:
2.1.1.356;

The binding sites of Zinc atom in the Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min (pdb code 9c8u). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 7 binding sites of Zinc where determined in the Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min, PDB code: 9c8u:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7;

Zinc binding site 1 out of 7 in the Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn801 b:102.9 occ:0.49 CE1 A:HIS530 2.0 106.5 1.0 NE2 A:HIS530 2.1 108.0 1.0 SG A:CYS535 2.3 109.7 1.0 SG A:CYS539 2.3 104.3 1.0 SG A:CYS528 2.3 94.1 1.0 ND1 A:HIS530 2.9 107.2 1.0 CB A:CYS539 3.0 106.2 1.0 CD2 A:HIS530 3.1 107.1 1.0 CB A:CYS535 3.4 106.5 1.0 CG A:HIS530 3.5 105.8 1.0 CB A:CYS528 3.5 89.6 1.0 CA A:CYS535 3.8 109.3 1.0 ZN A:ZN802 3.9 95.2 0.4 CB A:CYS554 4.0 94.1 1.0 ZN A:ZN803 4.0 108.9 0.7 SG A:CYS548 4.4 91.7 1.0 CA A:CYS539 4.4 109.1 1.0 N A:CYS535 4.6 109.1 1.0 CB A:HIS530 4.8 99.2 1.0 CA A:CYS554 4.8 93.5 1.0 CA A:CYS528 4.8 85.4 1.0 N A:CYS539 4.8 113.2 1.0 C A:CYS528 4.9 85.0 1.0

Zinc binding site 2 out of 7 in the Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn802 b:95.2 occ:0.43 SG A:CYS548 2.3 91.7 1.0 SG A:CYS552 2.3 87.8 1.0 SG A:CYS528 2.3 94.1 1.0 SG A:CYS541 2.3 91.6 1.0 CB A:CYS528 3.2 89.6 1.0 CB A:CYS552 3.3 79.9 1.0 CB A:CYS541 3.4 91.6 1.0 N A:CYS528 3.8 79.9 1.0 CB A:CYS548 3.9 85.3 1.0 ZN A:ZN801 3.9 102.9 0.5 ZN A:ZN803 3.9 108.9 0.7 CA A:CYS528 4.0 85.4 1.0 CA A:CYS548 4.2 80.5 1.0 CB A:CYS554 4.3 94.1 1.0 O A:CYS528 4.3 85.2 1.0 SG A:CYS535 4.5 109.7 1.0 SG A:CYS554 4.6 102.2 1.0 C A:CYS528 4.6 85.0 1.0 CA A:CYS552 4.7 74.6 1.0 C A:CYS548 4.8 75.8 1.0 SG A:CYS539 4.8 104.3 1.0 CA A:CYS541 4.8 100.9 1.0 N A:GLU549 4.9 72.0 1.0 C A:PRO527 5.0 75.0 1.0 C A:CYS552 5.0 77.6 1.0 N A:CYS554 5.0 90.3 1.0

Zinc binding site 3 out of 7 in the Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn803 b:108.9 occ:0.73 SG A:CYS554 2.3 102.2 1.0 SG A:CYS548 2.3 91.7 1.0 SG A:CYS558 2.3 96.0 1.0 SG A:CYS535 2.3 109.7 1.0 CB A:CYS554 2.6 94.1 1.0 CB A:CYS535 3.0 106.5 1.0 CB A:CYS558 3.0 95.3 1.0 CB A:CYS548 3.4 85.3 1.0 ZN A:ZN802 3.9 95.2 0.4 ZN A:ZN801 4.0 102.9 0.5 CA A:CYS554 4.1 93.5 1.0 CA A:CYS558 4.4 94.2 1.0 SG A:CYS528 4.5 94.1 1.0 CA A:CYS535 4.5 109.3 1.0 SG A:CYS552 4.6 87.8 1.0 CA A:CYS548 4.8 80.5 1.0 C A:CYS554 4.8 98.1 1.0 N A:SER555 4.8 99.3 1.0 N A:CYS554 4.9 90.3 1.0 O A:SER555 4.9 98.7 1.0 NE2 A:HIS530 4.9 108.0 1.0 CB A:ASN560 4.9 84.3 1.0

Zinc binding site 4 out of 7 in the Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn804 b:61.1 occ:0.62 SG A:CYS567 2.3 68.0 1.0 SG A:CYS576 2.3 54.7 1.0 SG A:CYS571 2.3 58.6 1.0 SG A:CYS565 2.3 59.0 1.0 CB A:CYS576 3.1 53.6 1.0 CB A:CYS567 3.1 58.6 1.0 CB A:CYS565 3.2 55.7 1.0 CB A:CYS571 3.4 46.5 1.0 ZN A:ZN806 3.8 47.1 0.0 ZN A:ZN805 3.9 38.9 0.5 CA A:CYS576 4.1 56.3 1.0 CA A:CYS571 4.1 48.3 1.0 SG A:CYS585 4.2 43.8 1.0 N A:CYS567 4.2 57.9 1.0 CA A:CYS567 4.3 58.4 1.0 CB A:CYS593 4.6 48.1 1.0 CA A:CYS565 4.6 52.5 1.0 CD A:PRO577 4.7 49.9 1.0 C A:CYS576 4.8 54.9 1.0 C A:CYS565 4.8 54.4 1.0 CB A:CYS578 4.8 41.6 1.0 SG A:CYS578 4.9 47.9 1.0 N A:CYS571 5.0 53.1 1.0 N A:PRO577 5.0 52.2 1.0

Zinc binding site 5 out of 7 in the Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn805 b:38.9 occ:0.46 SG A:CYS606 2.3 38.8 1.0 SG A:CYS571 2.3 58.6 1.0 SG A:CYS593 2.3 52.6 1.0 SG A:CYS585 2.3 43.8 1.0 CB A:CYS571 3.0 46.5 1.0 CB A:CYS593 3.1 48.1 1.0 CB A:CYS585 3.3 35.1 1.0 CB A:CYS606 3.3 45.3 1.0 ZN A:ZN806 3.9 47.1 0.0 ZN A:ZN804 3.9 61.1 0.6 SG A:CYS565 4.1 59.0 1.0 CA A:CYS593 4.5 50.6 1.0 CA A:CYS571 4.5 48.3 1.0 CA A:CYS606 4.5 47.9 1.0 O A:CYS593 4.6 50.2 1.0 CB A:ALA595 4.7 39.7 1.0 CA A:CYS585 4.7 30.3 1.0 C A:CYS593 4.7 49.2 1.0 CB A:ASN608 4.8 19.1 1.0 CB A:CYS590 4.8 42.0 1.0 O A:GLN570 5.0 51.1 1.0 N A:CYS571 5.0 53.1 1.0

Zinc binding site 6 out of 7 in the Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn806 b:47.1 occ:0.00 SG A:CYS590 2.3 53.5 1.0 SG A:CYS578 2.3 47.9 1.0 SG A:CYS585 2.3 43.8 1.0 SG A:CYS565 2.3 59.0 1.0 CB A:CYS565 3.2 55.7 1.0 CB A:CYS578 3.3 41.6 1.0 CB A:CYS585 3.4 35.1 1.0 CB A:CYS590 3.4 42.0 1.0 CA A:CYS585 3.8 30.3 1.0 ZN A:ZN804 3.8 61.1 0.6 N A:CYS565 3.8 53.8 1.0 ZN A:ZN805 3.9 38.9 0.5 CA A:CYS565 4.1 52.5 1.0 SG A:CYS576 4.4 54.7 1.0 O A:CYS565 4.5 52.4 1.0 SG A:CYS593 4.6 52.6 1.0 SG A:CYS571 4.6 58.6 1.0 CA A:CYS578 4.7 46.2 1.0 C A:CYS565 4.7 54.4 1.0 CA A:CYS590 4.7 44.6 1.0 C A:CYS585 4.8 31.5 1.0 N A:CYS585 4.8 26.9 1.0 N A:CYS578 4.9 52.4 1.0 N A:ASP586 4.9 34.7 1.0

Zinc binding site 7 out of 7 in the Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn807 b:29.7 occ:0.64 ND1 A:HIS297 2.1 24.9 1.0 SG A:CYS289 2.3 43.1 1.0 SG A:CYS294 2.3 30.2 1.0 SG A:CYS286 2.3 32.9 1.0 CE1 A:HIS297 2.8 23.6 1.0 CB A:CYS294 3.0 25.9 1.0 CG A:HIS297 3.3 25.5 1.0 CB A:CYS286 3.3 27.8 1.0 CB A:CYS289 3.4 21.6 1.0 CB A:HIS297 3.8 26.0 1.0 NE2 A:HIS297 4.0 24.5 1.0 N A:CYS289 4.1 24.3 1.0 CD2 A:HIS297 4.3 25.4 1.0 N A:HIS297 4.3 26.2 1.0 CA A:CYS289 4.4 22.1 1.0 CA A:CYS294 4.4 24.6 1.0 O A:CYS286 4.5 28.7 1.0 CB A:ARG288 4.6 27.0 1.0 CA A:CYS286 4.6 30.3 1.0 CA A:HIS297 4.7 27.2 1.0 C A:ARG288 4.7 25.8 1.0 C A:CYS286 4.8 29.2 1.0 O A:HIS297 5.0 40.0 1.0 N A:CYS294 5.0 27.1 1.0

K.M.Abe, G.Li, Q.He, T.Grant, C.Lim. Human PRC2 - Rvleam (Short) (1:6 Molar Ratio), Cross-Linked 10 Min To Be Published.