Zinc in PDB 8zsz: Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation

The binding sites of Zinc atom in the Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation (pdb code 8zsz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation, PDB code: 8zsz:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Zinc binding site 1 out of 8 in the Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:142.8 occ:1.00 OE2 A:GLU420 1.7 114.9 1.0 NE2 B:HIS157 2.0 126.8 1.0 NE2 A:HIS370 2.1 97.5 1.0 CD A:GLU420 2.7 114.9 1.0 CD2 B:HIS157 2.8 126.8 1.0 CE1 B:HIS157 2.8 126.8 1.0 CE1 A:HIS370 3.0 97.5 1.0 CD2 A:HIS370 3.1 97.5 1.0 OE1 A:GLU420 3.3 114.9 1.0 ND1 A:HIS387 3.6 95.6 1.0 ND1 B:HIS157 3.7 126.8 1.0 CG B:HIS157 3.7 126.8 1.0 O B:HIS157 3.8 126.8 1.0 CE1 A:HIS387 3.8 95.6 1.0 CG A:GLU420 3.9 114.9 1.0 CG A:HIS387 4.0 95.6 1.0 ND1 A:HIS370 4.1 97.5 1.0 CG A:HIS370 4.2 97.5 1.0 NE2 A:HIS387 4.2 95.6 1.0 CD2 A:HIS387 4.4 95.6 1.0 CB A:HIS387 4.6 95.6 1.0 C B:HIS157 4.8 126.8 1.0

Zinc binding site 2 out of 8 in the Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn602 b:87.1 occ:1.00 OD1 A:ASP255 1.8 57.5 1.0 OD1 A:ASP47 2.0 56.3 1.0 NE2 A:HIS43 2.0 67.5 1.0 NE2 A:HIS251 2.1 43.1 1.0 CG A:ASP255 2.4 57.5 1.0 OD2 A:ASP255 2.5 57.5 1.0 CE1 A:HIS43 2.9 67.5 1.0 CD2 A:HIS43 3.0 67.5 1.0 CD2 A:HIS251 3.0 43.1 1.0 CG A:ASP47 3.1 56.3 1.0 CE1 A:HIS251 3.1 43.1 1.0 OD2 A:ASP47 3.5 56.3 1.0 CB A:ASP255 3.9 57.5 1.0 ND1 A:HIS43 3.9 67.5 1.0 CG A:HIS43 4.0 67.5 1.0 CG A:HIS251 4.1 43.1 1.0 ND1 A:HIS251 4.1 43.1 1.0 CB A:ASP47 4.3 56.3 1.0 N A:ASP47 4.4 56.3 1.0 CA A:ASP47 4.5 56.3 1.0 CA A:ASP255 4.5 57.5 1.0 O A:HIS43 4.5 67.5 1.0 N A:ASP255 4.7 57.5 1.0 CD1 A:LEU92 4.8 26.2 1.0 CB A:SER46 4.9 58.8 1.0 C A:SER46 5.0 58.8 1.0

Zinc binding site 3 out of 8 in the Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn603 b:106.6 occ:1.00 NE2 A:HIS373 1.7 58.6 1.0 NE2 B:HIS148 1.9 82.8 1.0 OE2 A:GLU371 1.9 79.2 1.0 NE2 B:HIS146 2.2 74.0 1.0 CE1 A:HIS373 2.6 58.6 1.0 CD2 A:HIS373 2.7 58.6 1.0 CE1 B:HIS148 2.8 82.8 1.0 CD2 B:HIS148 2.9 82.8 1.0 CD2 B:HIS146 2.9 74.0 1.0 CD A:GLU371 2.9 79.2 1.0 CE1 B:HIS146 3.0 74.0 1.0 O B:HIS146 3.2 74.0 1.0 OE1 A:GLU371 3.5 79.2 1.0 ND1 A:HIS373 3.7 58.6 1.0 CG A:HIS373 3.8 58.6 1.0 CG B:HIS146 3.8 74.0 1.0 ND1 B:HIS146 3.9 74.0 1.0 ND1 B:HIS148 3.9 82.8 1.0 CG B:HIS148 4.0 82.8 1.0 CG A:GLU371 4.0 79.2 1.0 CB A:GLU371 4.3 79.2 1.0 C B:HIS146 4.4 74.0 1.0 CA A:GLU371 4.8 79.2 1.0

Zinc binding site 4 out of 8 in the Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn604 b:117.2 occ:1.00 ND1 A:HIS408 2.0 30.0 1.0 NE2 A:HIS413 2.2 94.8 1.0 NE2 A:HIS153 2.2 116.3 1.0 NE2 A:HIS155 2.4 125.9 1.0 CG A:HIS408 2.8 30.0 1.0 CE1 A:HIS408 3.0 30.0 1.0 CE1 A:HIS413 3.0 94.8 1.0 CD2 A:HIS413 3.1 94.8 1.0 CB A:HIS408 3.1 30.0 1.0 CD2 A:HIS153 3.1 116.3 1.0 CD2 A:HIS155 3.2 125.9 1.0 CE1 A:HIS153 3.2 116.3 1.0 CE1 A:HIS155 3.3 125.9 1.0 CD2 A:HIS408 3.9 30.0 1.0 NE2 A:HIS408 4.0 30.0 1.0 ND1 A:HIS413 4.0 94.8 1.0 CG A:HIS413 4.1 94.8 1.0 CG A:HIS155 4.2 125.9 1.0 ND1 A:HIS155 4.2 125.9 1.0 ND1 A:HIS153 4.3 116.3 1.0 CG A:HIS153 4.3 116.3 1.0 CA A:HIS408 4.4 108.4 1.0 O A:HIS153 4.5 116.3 1.0 C A:HIS408 4.8 108.4 1.0 O A:HIS408 4.9 108.4 1.0

Zinc binding site 5 out of 8 in the Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn601 b:145.1 occ:1.00 OE2 B:GLU420 1.6 117.5 1.0 NE2 A:HIS157 1.9 128.2 1.0 NE2 B:HIS370 1.9 99.1 1.0 CD B:GLU420 2.7 117.5 1.0 CD2 A:HIS157 2.7 128.2 1.0 CE1 A:HIS157 2.7 128.2 1.0 CE1 B:HIS370 2.8 99.1 1.0 CD2 B:HIS370 2.9 99.1 1.0 ND1 B:HIS387 3.1 96.7 1.0 OE1 B:GLU420 3.2 117.5 1.0 O A:HIS157 3.5 128.2 1.0 CE1 B:HIS387 3.5 96.7 1.0 ND1 A:HIS157 3.6 128.2 1.0 CG A:HIS157 3.6 128.2 1.0 CG B:GLU420 3.9 117.5 1.0 CG B:HIS387 3.9 96.7 1.0 ND1 B:HIS370 3.9 99.1 1.0 CG B:HIS370 4.0 99.1 1.0 CB B:HIS387 4.4 96.7 1.0 NE2 B:HIS387 4.4 96.7 1.0 C A:HIS157 4.6 128.2 1.0 CD2 B:HIS387 4.7 96.7 1.0 CB A:HIS157 4.9 128.2 1.0 OE1 B:GLN418 5.0 99.8 1.0

Zinc binding site 6 out of 8 in the Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn602 b:86.0 occ:1.00 OD1 B:ASP255 1.8 57.5 1.0 NE2 B:HIS43 2.0 66.0 1.0 OD1 B:ASP47 2.0 54.7 1.0 NE2 B:HIS251 2.1 43.0 1.0 CG B:ASP255 2.5 57.5 1.0 OD2 B:ASP255 2.6 57.5 1.0 CE1 B:HIS43 2.9 66.0 1.0 CD2 B:HIS43 2.9 66.0 1.0 CD2 B:HIS251 3.0 43.0 1.0 CG B:ASP47 3.1 54.7 1.0 CE1 B:HIS251 3.1 43.0 1.0 OD2 B:ASP47 3.5 54.7 1.0 ND1 B:HIS43 3.9 66.0 1.0 CB B:ASP255 3.9 57.5 1.0 CG B:HIS43 3.9 66.0 1.0 CG B:HIS251 4.1 43.0 1.0 ND1 B:HIS251 4.1 43.0 1.0 CB B:ASP47 4.3 54.7 1.0 O B:HIS43 4.4 66.0 1.0 N B:ASP47 4.4 54.7 1.0 CA B:ASP255 4.5 57.5 1.0 CA B:ASP47 4.5 54.7 1.0 N B:ASP255 4.7 57.5 1.0 CD1 B:LEU92 4.8 25.5 1.0

Zinc binding site 7 out of 8 in the Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn603 b:105.9 occ:1.00 NE2 B:HIS373 1.6 58.7 1.0 NE2 A:HIS148 1.8 81.9 1.0 OE2 B:GLU371 1.9 80.0 1.0 NE2 A:HIS146 2.2 73.5 1.0 CE1 B:HIS373 2.6 58.7 1.0 CD2 B:HIS373 2.6 58.7 1.0 CE1 A:HIS148 2.8 81.9 1.0 CD2 A:HIS148 2.9 81.9 1.0 CD B:GLU371 2.9 80.0 1.0 CD2 A:HIS146 2.9 73.5 1.0 O A:HIS146 3.0 73.5 1.0 CE1 A:HIS146 3.0 73.5 1.0 OE1 B:GLU371 3.5 80.0 1.0 ND1 B:HIS373 3.7 58.7 1.0 CG B:HIS373 3.7 58.7 1.0 CG A:HIS146 3.8 73.5 1.0 ND1 A:HIS146 3.8 73.5 1.0 ND1 A:HIS148 3.9 81.9 1.0 CG A:HIS148 4.0 81.9 1.0 CG B:GLU371 4.0 80.0 1.0 C A:HIS146 4.2 73.5 1.0 CB B:GLU371 4.3 80.0 1.0 CA B:GLU371 4.8 80.0 1.0 CA A:GLY147 4.9 75.3 1.0 CB A:HIS146 5.0 73.5 1.0

Zinc binding site 8 out of 8 in the Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Cryo-Em Structure of Human ZNT1, in the Presence of Zinc, Determined in Outward-Facing Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn604 b:118.4 occ:1.00 NE2 B:HIS413 1.9 94.9 1.0 NE2 B:HIS155 2.1 124.7 1.0 NE2 B:HIS153 2.4 115.9 1.0 CE1 B:HIS413 2.9 94.9 1.0 ND1 B:HIS408 2.9 30.0 1.0 CD2 B:HIS413 2.9 94.9 1.0 CD2 B:HIS155 3.1 124.7 1.0 CE1 B:HIS155 3.1 124.7 1.0 CG B:HIS408 3.2 30.0 1.0 CD2 B:HIS153 3.2 115.9 1.0 CE1 B:HIS153 3.3 115.9 1.0 CB B:HIS408 3.4 30.0 1.0 CE1 B:HIS408 3.6 30.0 1.0 ND1 B:HIS413 3.9 94.9 1.0 CG B:HIS413 4.0 94.9 1.0 CD2 B:HIS408 4.0 30.0 1.0 ND1 B:HIS155 4.2 124.7 1.0 NE2 B:HIS408 4.2 30.0 1.0 CG B:HIS155 4.2 124.7 1.0 CG B:HIS153 4.3 115.9 1.0 ND1 B:HIS153 4.3 115.9 1.0 O B:HIS153 4.4 115.9 1.0 CA B:HIS408 4.6 108.9 1.0

Y.Li, J.Ma, R.Wang, Y.Luo, S.Zheng, X.Wang. Zinc Transporter 1 Functions in Copper Uptake and Cuproptosis To Be Published.