Zinc in PDB 8zb0: Cryo-Em Structure of Human ZNT1

The binding sites of Zinc atom in the Cryo-Em Structure of Human ZNT1 (pdb code 8zb0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the Cryo-Em Structure of Human ZNT1, PDB code: 8zb0:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Zinc binding site 1 out of 8 in the Cryo-Em Structure of Human ZNT1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of Human ZNT1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:93.2 occ:1.00 SG A:CYS321 3.1 20.8 1.0 OD1 A:ASP317 3.7 23.4 1.0 OD2 A:ASP317 3.9 23.4 1.0 CG A:ASP317 4.2 23.4 1.0 CB A:CYS321 4.4 20.8 1.0 OE2 A:GLU99 4.6 28.9 1.0 NH1 A:ARG103 4.7 34.4 1.0 CG A:ARG103 4.8 34.4 1.0 CD A:GLU99 4.9 28.9 1.0

Zinc binding site 2 out of 8 in the Cryo-Em Structure of Human ZNT1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of Human ZNT1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn602 b:110.3 occ:1.00 OD1 A:ASP255 1.8 35.7 1.0 OD2 A:ASP47 1.8 39.0 1.0 CG A:ASP47 2.2 39.0 1.0 CG A:ASP255 2.3 35.7 1.0 CB A:ASP47 2.6 39.0 1.0 OD2 A:ASP255 3.0 35.7 1.0 CB A:ASP255 3.0 35.7 1.0 OD1 A:ASP47 3.1 39.0 1.0 CA A:ASP47 3.9 39.0 1.0 CA A:ASP255 4.4 35.7 1.0 N A:ASP47 4.6 39.0 1.0 O A:HIS251 4.8 30.7 1.0 N A:ASP255 4.9 35.7 1.0 C A:ASP47 5.0 39.0 1.0

Zinc binding site 3 out of 8 in the Cryo-Em Structure of Human ZNT1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Cryo-Em Structure of Human ZNT1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn603 b:62.8 occ:1.00 ND1 A:HIS408 1.7 34.3 1.0 SG B:CYS437 2.0 48.9 1.0 CE1 A:HIS408 2.0 34.3 1.0 ND1 A:HIS413 2.1 20.9 1.0 CE1 A:HIS413 2.7 20.9 1.0 CG A:HIS408 2.9 34.3 1.0 NE2 A:HIS408 3.2 34.3 1.0 CG A:HIS413 3.2 20.9 1.0 CB B:CYS437 3.5 48.9 1.0 CD2 A:HIS408 3.6 34.3 1.0 CB A:HIS408 3.8 34.3 1.0 CB A:HIS413 3.8 20.9 1.0 NE2 A:HIS413 3.9 20.9 1.0 CD2 A:HIS413 4.1 20.9 1.0 NE2 B:GLN440 4.2 53.5 1.0 CA A:HIS408 4.4 34.3 1.0 CA A:HIS413 4.4 20.9 1.0 CA B:CYS437 4.7 48.9 1.0 O B:GLN440 4.8 53.5 1.0 O A:HIS408 4.9 34.3 1.0

Zinc binding site 4 out of 8 in the Cryo-Em Structure of Human ZNT1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Cryo-Em Structure of Human ZNT1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn604 b:43.2 occ:1.00 OE2 A:GLU420 1.7 31.8 1.0 SG A:CYS433 1.9 44.1 1.0 ND1 A:HIS387 2.3 17.0 1.0 CB A:CYS433 2.4 44.1 1.0 CD A:GLU420 2.5 31.8 1.0 OE1 A:GLU420 2.8 31.8 1.0 ND1 A:HIS370 3.0 21.8 1.0 CG A:HIS387 3.2 17.0 1.0 CE1 A:HIS387 3.2 17.0 1.0 CB A:HIS387 3.5 17.0 1.0 CA A:CYS433 3.6 44.1 1.0 CG A:HIS370 3.6 21.8 1.0 CB A:HIS370 3.6 21.8 1.0 CG A:GLU420 4.0 31.8 1.0 CE1 A:HIS370 4.0 21.8 1.0 O A:CYS433 4.0 44.1 1.0 NE2 A:HIS387 4.3 17.0 1.0 CD2 A:HIS387 4.3 17.0 1.0 C A:CYS433 4.3 44.1 1.0 O A:LEU435 4.7 45.1 1.0 CD2 A:HIS370 4.7 21.8 1.0 N A:CYS433 4.7 44.1 1.0 NE2 A:HIS370 4.9 21.8 1.0 CA A:HIS387 5.0 17.0 1.0

Zinc binding site 5 out of 8 in the Cryo-Em Structure of Human ZNT1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Cryo-Em Structure of Human ZNT1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn601 b:93.2 occ:1.00 SG B:CYS321 3.1 20.8 1.0 OD1 B:ASP317 3.7 23.4 1.0 OD2 B:ASP317 3.9 23.4 1.0 CG B:ASP317 4.2 23.4 1.0 CB B:CYS321 4.4 20.8 1.0 OE2 B:GLU99 4.6 28.9 1.0 NH1 B:ARG103 4.7 34.4 1.0 CG B:ARG103 4.8 34.4 1.0 CD B:GLU99 4.9 28.9 1.0

Zinc binding site 6 out of 8 in the Cryo-Em Structure of Human ZNT1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 6 of Cryo-Em Structure of Human ZNT1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn602 b:110.3 occ:1.00 OD1 B:ASP255 1.8 35.7 1.0 OD2 B:ASP47 1.8 39.0 1.0 CG B:ASP47 2.2 39.0 1.0 CG B:ASP255 2.3 35.7 1.0 CB B:ASP47 2.6 39.0 1.0 OD2 B:ASP255 3.0 35.7 1.0 CB B:ASP255 3.0 35.7 1.0 OD1 B:ASP47 3.1 39.0 1.0 CA B:ASP47 3.9 39.0 1.0 CA B:ASP255 4.4 35.7 1.0 N B:ASP47 4.6 39.0 1.0 O B:HIS251 4.8 30.7 1.0 N B:ASP255 4.9 35.7 1.0 C B:ASP47 5.0 39.0 1.0

Zinc binding site 7 out of 8 in the Cryo-Em Structure of Human ZNT1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 7 of Cryo-Em Structure of Human ZNT1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn603 b:62.8 occ:1.00 ND1 B:HIS408 1.7 34.3 1.0 SG A:CYS437 2.0 48.9 1.0 CE1 B:HIS408 2.0 34.3 1.0 ND1 B:HIS413 2.1 20.9 1.0 CE1 B:HIS413 2.7 20.9 1.0 CG B:HIS408 2.9 34.3 1.0 NE2 B:HIS408 3.2 34.3 1.0 CG B:HIS413 3.2 20.9 1.0 CB A:CYS437 3.6 48.9 1.0 CD2 B:HIS408 3.6 34.3 1.0 CB B:HIS408 3.8 34.3 1.0 CB B:HIS413 3.8 20.9 1.0 NE2 B:HIS413 3.9 20.9 1.0 CD2 B:HIS413 4.1 20.9 1.0 NE2 A:GLN440 4.3 53.5 1.0 CA B:HIS408 4.4 34.3 1.0 CA B:HIS413 4.4 20.9 1.0 CA A:CYS437 4.8 48.9 1.0 O B:HIS408 4.9 34.3 1.0 O A:GLN440 5.0 53.5 1.0

Zinc binding site 8 out of 8 in the Cryo-Em Structure of Human ZNT1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 8 of Cryo-Em Structure of Human ZNT1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn604 b:43.2 occ:1.00 OE2 B:GLU420 1.7 31.8 1.0 SG B:CYS433 1.9 44.1 1.0 ND1 B:HIS387 2.3 17.0 1.0 CB B:CYS433 2.4 44.1 1.0 CD B:GLU420 2.5 31.8 1.0 OE1 B:GLU420 2.8 31.8 1.0 ND1 B:HIS370 3.0 21.8 1.0 CG B:HIS387 3.2 17.0 1.0 CE1 B:HIS387 3.2 17.0 1.0 CB B:HIS387 3.5 17.0 1.0 CA B:CYS433 3.6 44.1 1.0 CG B:HIS370 3.6 21.8 1.0 CB B:HIS370 3.6 21.8 1.0 CG B:GLU420 4.0 31.8 1.0 CE1 B:HIS370 4.0 21.8 1.0 O B:CYS433 4.0 44.1 1.0 NE2 B:HIS387 4.3 17.0 1.0 CD2 B:HIS387 4.3 17.0 1.0 C B:CYS433 4.3 44.1 1.0 O B:LEU435 4.7 45.1 1.0 CD2 B:HIS370 4.7 21.8 1.0 N B:CYS433 4.7 44.1 1.0 NE2 B:HIS370 4.9 21.8 1.0 CA B:HIS387 5.0 17.0 1.0

S.Sun, E.Xie, S.Xu, S.Ji, S.Wang, J.Shen, R.Wang, X.Shen, Y.Su, Z.Song, X.Wu, J.Zhou, Z.Cai, X.Li, Y.Zhang, J.Min, F.Wang. The Intestinal Transporter SLC30A1 Plays A Critical Role in Regulating Systemic Zinc Homeostasis. Adv Sci V. 11 06421 2024.
ISSN: ESSN 2198-3844
PubMed: 39422023
DOI: 10.1002/ADVS.202406421