Zinc in PDB 8xpn: The Crystal Structure of USP8 From Biortus.

All present enzymatic activity of The Crystal Structure of USP8 From Biortus.:
3.4.19.12;

The structure of The Crystal Structure of USP8 From Biortus., PDB code: 8xpn was solved by F.Wang, W.Cheng, Z.Yuan, D.Lin, J.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.78 / 2.10
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	57.83, 109.342, 180.992, 90, 90, 90
R / Rfree (%)	17.7 / 21.6

The binding sites of Zinc atom in the The Crystal Structure of USP8 From Biortus. (pdb code 8xpn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the The Crystal Structure of USP8 From Biortus., PDB code: 8xpn:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the The Crystal Structure of USP8 From Biortus.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Crystal Structure of USP8 From Biortus. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1201 b:56.1 occ:1.00 SG A:CYS939 2.3 49.6 1.0 SG A:CYS936 2.3 57.2 1.0 SG A:CYS988 2.4 75.7 1.0 SG A:CYS985 2.4 54.9 1.0 CB A:CYS936 3.2 49.0 1.0 CB A:CYS985 3.3 54.4 1.0 CB A:CYS939 3.4 55.7 1.0 CB A:CYS988 3.4 79.0 1.0 N A:CYS939 3.8 55.8 1.0 N A:CYS988 3.9 82.8 1.0 CA A:CYS939 4.1 55.0 1.0 CA A:CYS988 4.1 80.4 1.0 CG A:ARG992 4.2 74.0 1.0 CB A:THR938 4.5 59.0 1.0 CA A:CYS936 4.6 44.8 1.0 CA A:CYS985 4.8 60.6 1.0 C A:HIS987 4.8 83.9 1.0 CB A:ARG992 4.8 71.6 1.0 CB A:HIS987 4.9 87.6 1.0 C A:THR938 4.9 59.3 1.0 ND1 A:HIS987 4.9 98.1 1.0 C A:CYS939 4.9 54.7 1.0 CB A:LYS941 4.9 68.7 1.0 NE A:ARG992 4.9 79.0 1.0 CD A:ARG992 5.0 76.2 1.0

Zinc binding site 2 out of 3 in the The Crystal Structure of USP8 From Biortus.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The Crystal Structure of USP8 From Biortus. within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1203 b:22.5 occ:1.00 SG B:CYS936 2.3 22.0 1.0 SG B:CYS939 2.3 20.6 1.0 SG B:CYS985 2.3 25.1 1.0 SG B:CYS988 2.3 27.9 1.0 CB B:CYS936 3.1 22.0 1.0 CB B:CYS939 3.3 22.2 1.0 CB B:CYS988 3.3 30.1 1.0 CB B:CYS985 3.4 28.3 1.0 N B:CYS939 3.8 22.5 1.0 N B:CYS988 3.8 36.6 1.0 CA B:CYS988 4.1 33.5 1.0 CA B:CYS939 4.1 20.9 1.0 ND1 B:HIS987 4.4 31.3 1.0 CG B:ARG992 4.4 35.8 1.0 CB B:THR938 4.5 20.2 1.0 CA B:CYS936 4.6 21.8 1.0 CB B:LYS941 4.8 30.1 1.0 C B:THR938 4.8 22.1 1.0 CA B:CYS985 4.8 30.6 1.0 NE B:ARG992 4.8 43.4 1.0 C B:CYS939 4.8 20.0 1.0 CB B:HIS987 4.9 37.6 1.0 C B:HIS987 4.9 36.1 1.0 N B:HIS940 5.0 20.8 1.0 CA B:THR938 5.0 20.5 1.0 N B:THR938 5.0 21.4 1.0

Zinc binding site 3 out of 3 in the The Crystal Structure of USP8 From Biortus.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of The Crystal Structure of USP8 From Biortus. within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1202 b:99.7 occ:1.00 SG C:CYS939 2.3 87.2 1.0 SG C:CYS936 2.3 78.1 1.0 CB C:CYS936 3.2 85.1 1.0 CB C:CYS939 3.5 94.6 1.0 N C:CYS939 3.6 96.8 1.0 CB C:THR938 4.1 99.7 1.0 CA C:CYS939 4.1 96.5 1.0 C C:THR938 4.6 99.0 1.0 CA C:CYS936 4.7 83.2 1.0 CG2 C:THR938 4.7 99.7 1.0 CA C:THR938 4.8 99.5 1.0 N C:THR938 4.9 99.8 1.0 OG1 C:THR938 5.0 99.0 1.0 C C:CYS939 5.0 98.0 1.0

F.Wang, W.Cheng, Z.Yuan, D.Lin, J.Wang. The Crystal Structure of USP8 From Biortus. To Be Published.