Zinc in PDB 8xe7: Crystal Structure of Human SIRT2 Without SIRT2-Specific Insertion

The structure of Crystal Structure of Human SIRT2 Without SIRT2-Specific Insertion, PDB code: 8xe7 was solved by T.Konuma, S.Akashi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.49 / 1.95
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	34.893, 69.208, 61.171, 90, 99.34, 90
R / Rfree (%)	21 / 25.6

The binding sites of Zinc atom in the Crystal Structure of Human SIRT2 Without SIRT2-Specific Insertion (pdb code 8xe7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human SIRT2 Without SIRT2-Specific Insertion, PDB code: 8xe7:

Zinc binding site 1 out of 1 in the Crystal Structure of Human SIRT2 Without SIRT2-Specific Insertion


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human SIRT2 Without SIRT2-Specific Insertion within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:31.5 occ:1.00 SG A:CYS224 2.3 35.3 1.0 SG A:CYS221 2.3 27.5 1.0 SG A:CYS200 2.3 32.7 1.0 SG A:CYS195 2.3 27.8 1.0 CB A:CYS221 3.1 28.6 1.0 CB A:CYS195 3.1 24.9 1.0 CB A:CYS200 3.2 34.8 1.0 CB A:CYS224 3.6 33.9 1.0 N A:CYS224 4.0 31.3 1.0 CA A:CYS224 4.3 31.4 1.0 CB A:HIS202 4.4 33.0 1.0 CA A:CYS195 4.5 24.3 1.0 CA A:CYS200 4.6 36.0 1.0 CA A:CYS221 4.6 27.4 1.0 N A:ARG201 4.6 31.7 1.0 N A:HIS202 4.6 28.6 1.0 CB A:SER226 4.7 27.9 1.0 CB A:ASP223 4.7 34.9 1.0 O A:HOH623 4.7 42.5 1.0 OG A:SER226 4.8 33.7 1.0 CB A:SER197 4.8 34.5 1.0 C A:CYS200 4.8 35.4 1.0 C A:CYS224 4.9 31.3 1.0 N A:SER226 4.9 28.4 1.0 C A:ASP223 5.0 35.7 1.0

N.Suzuki, T.Konuma, T.Ikegami, S.Akashi. Biophysical Insights Into the Dimer Formation of Human Sirtuin 2. Protein Sci. V. 33 E4994 2024.
ISSN: ESSN 1469-896X
PubMed: 38647411
DOI: 10.1002/PRO.4994