Zinc in PDB 8vpq: The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4IPR310DELINSTTYML

All present enzymatic activity of The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4IPR310DELINSTTYML:
3.5.1.98;

The binding sites of Zinc atom in the The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4IPR310DELINSTTYML (pdb code 8vpq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4IPR310DELINSTTYML, PDB code: 8vpq:

Zinc binding site 1 out of 1 in the The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4IPR310DELINSTTYML


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The Structure of LSD1-Corest-HDAC1 in Complex with KBTBD4IPR310DELINSTTYML within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn600 b:29.0 occ:1.00 OD2 C:ASP176 2.0 44.7 1.0 ND1 C:HIS178 2.4 42.2 1.0 OD1 C:ASP176 2.4 44.7 1.0 CG C:ASP176 2.5 44.7 1.0 CE1 C:HIS178 3.2 42.2 1.0 OD2 C:ASP264 3.2 46.5 1.0 CG C:HIS178 3.4 42.2 1.0 CG2 C:ILE177 3.7 42.0 1.0 CB C:ASP264 3.7 46.5 1.0 CG C:ASP264 3.7 46.5 1.0 CB C:HIS178 3.8 42.2 1.0 CB C:ASP176 4.0 44.7 1.0 N C:HIS178 4.0 42.2 1.0 CA C:GLY301 4.1 44.8 1.0 N C:ILE177 4.4 42.0 1.0 NE2 C:HIS178 4.4 42.2 1.0 CD2 C:HIS178 4.5 42.2 1.0 CA C:HIS178 4.6 42.2 1.0 NE2 C:HIS140 4.6 46.8 1.0 OD1 C:ASP264 4.7 46.5 1.0 OH C:TYR303 4.8 50.2 1.0 CE1 C:HIS141 4.8 49.0 1.0 CA C:ASP176 4.9 44.7 1.0 CB C:ILE177 4.9 42.0 1.0 CE2 C:TYR303 4.9 50.2 1.0 C C:ASP176 4.9 44.7 1.0 CE1 C:HIS140 4.9 46.8 1.0 C C:ILE177 4.9 42.0 1.0 CA C:ILE177 4.9 42.0 1.0 N C:GLY301 5.0 44.8 1.0

X.Xie, B.Liau, N.Zheng. Molecular Mechanism Underlying KBTBD4 Cancer Mutation-Driven Degradation of Hdac Corepressor Complexes To Be Published.