Zinc in PDB 8sqk: Sars-Cov-2 Replication-Transcription Complex Bound to Rna-NSP9 and Gdp-Betas, As A Pre-Catalytic Dernaylation/Mrna Capping Intermediate

Enzymatic activity of Sars-Cov-2 Replication-Transcription Complex Bound to Rna-NSP9 and Gdp-Betas, As A Pre-Catalytic Dernaylation/Mrna Capping Intermediate

All present enzymatic activity of Sars-Cov-2 Replication-Transcription Complex Bound to Rna-NSP9 and Gdp-Betas, As A Pre-Catalytic Dernaylation/Mrna Capping Intermediate:
2.7.7.48;

Other elements in 8sqk:

The structure of Sars-Cov-2 Replication-Transcription Complex Bound to Rna-NSP9 and Gdp-Betas, As A Pre-Catalytic Dernaylation/Mrna Capping Intermediate also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Sars-Cov-2 Replication-Transcription Complex Bound to Rna-NSP9 and Gdp-Betas, As A Pre-Catalytic Dernaylation/Mrna Capping Intermediate (pdb code 8sqk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Sars-Cov-2 Replication-Transcription Complex Bound to Rna-NSP9 and Gdp-Betas, As A Pre-Catalytic Dernaylation/Mrna Capping Intermediate, PDB code: 8sqk:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 8sqk

Go back to Zinc Binding Sites List in 8sqk
Zinc binding site 1 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to Rna-NSP9 and Gdp-Betas, As A Pre-Catalytic Dernaylation/Mrna Capping Intermediate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Sars-Cov-2 Replication-Transcription Complex Bound to Rna-NSP9 and Gdp-Betas, As A Pre-Catalytic Dernaylation/Mrna Capping Intermediate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1003

b:103.2
occ:1.00
ND1 A:HIS295 2.1 45.9 1.0
SG A:CYS310 2.3 30.3 1.0
SG A:CYS306 2.3 47.5 1.0
SG A:CYS301 2.3 31.7 1.0
CE1 A:HIS295 2.9 34.9 1.0
HE1 A:HIS295 3.0 38.0 1.0
HA A:CYS301 3.1 31.6 1.0
HB2 A:HIS295 3.1 37.3 1.0
CG A:HIS295 3.2 40.0 1.0
CB A:CYS301 3.4 32.3 1.0
HB3 A:CYS301 3.5 31.3 1.0
O A:CYS306 3.6 37.7 1.0
H A:HIS295 3.6 39.3 1.0
HB2 A:CYS310 3.7 33.6 1.0
CB A:HIS295 3.7 31.9 1.0
CB A:CYS310 3.7 29.5 1.0
CA A:CYS301 3.7 28.0 1.0
CB A:CYS306 3.8 19.3 1.0
HB3 A:CYS306 3.8 29.8 1.0
C A:CYS306 4.1 31.6 1.0
HB3 A:CYS310 4.1 34.2 1.0
NE2 A:HIS295 4.1 30.4 1.0
H A:LEU302 4.2 29.6 1.0
HB2 A:CYS301 4.2 31.6 1.0
CD2 A:HIS295 4.3 36.0 1.0
N A:HIS295 4.3 35.1 1.0
HB3 A:HIS295 4.4 38.1 1.0
O A:HOH1135 4.4 39.3 1.0
HD1 A:HIS309 4.4 31.9 1.0
H A:CYS310 4.4 32.7 1.0
CA A:CYS306 4.5 28.1 1.0
HB2 A:CYS306 4.5 29.6 1.0
N A:CYS301 4.5 30.5 1.0
HA A:ILE307 4.6 30.9 1.0
HA A:CYS306 4.6 31.7 1.0
CA A:HIS295 4.6 23.3 1.0
H A:CYS301 4.7 32.5 1.0
HA A:CYS298 4.8 37.7 1.0
HG23 A:THR293 4.8 44.1 1.0
HA A:TYR294 4.8 48.9 1.0
N A:LEU302 4.8 32.3 1.0
C A:CYS301 4.8 28.5 1.0
HE2 A:HIS295 4.8 37.9 1.0
N A:ILE307 4.9 31.1 1.0
O A:THR293 4.9 47.9 1.0
HG A:LEU302 4.9 28.9 1.0
CA A:CYS310 4.9 23.1 1.0
N A:CYS310 4.9 29.7 1.0

Zinc binding site 2 out of 2 in 8sqk

Go back to Zinc Binding Sites List in 8sqk
Zinc binding site 2 out of 2 in the Sars-Cov-2 Replication-Transcription Complex Bound to Rna-NSP9 and Gdp-Betas, As A Pre-Catalytic Dernaylation/Mrna Capping Intermediate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Sars-Cov-2 Replication-Transcription Complex Bound to Rna-NSP9 and Gdp-Betas, As A Pre-Catalytic Dernaylation/Mrna Capping Intermediate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1004

b:94.3
occ:1.00
ND1 A:HIS642 2.1 34.3 1.0
SG A:CYS645 2.3 44.4 1.0
SG A:CYS487 2.3 30.2 1.0
SG A:CYS646 2.3 39.4 1.0
HB3 A:HIS642 2.5 30.0 1.0
CG A:HIS642 3.0 31.6 1.0
CE1 A:HIS642 3.2 25.9 1.0
CB A:HIS642 3.2 24.1 1.0
HE1 A:HIS642 3.4 30.5 1.0
HB2 A:CYS646 3.4 31.4 1.0
HE1 A:PHE571 3.5 29.9 1.0
CB A:CYS646 3.5 25.9 1.0
HB2 A:CYS645 3.6 34.3 1.0
CB A:CYS645 3.6 31.8 1.0
CB A:CYS487 3.9 40.8 1.0
H A:CYS646 3.9 32.5 1.0
HA A:HIS642 3.9 30.4 1.0
HB2 A:HIS642 3.9 29.4 1.0
H A:CYS487 3.9 33.9 1.0
N A:CYS646 3.9 34.2 1.0
HB2 A:CYS487 4.0 36.2 1.0
HA2 A:GLY486 4.1 31.6 1.0
CE1 A:PHE571 4.1 27.0 1.0
N A:CYS487 4.1 29.9 1.0
CA A:HIS642 4.2 28.3 1.0
CD2 A:HIS642 4.2 31.0 1.0
C A:CYS645 4.2 37.9 1.0
NE2 A:HIS642 4.3 24.1 1.0
HB3 A:CYS646 4.3 30.8 1.0
HD1 A:PHE571 4.3 30.8 1.0
CA A:CYS646 4.3 31.3 1.0
HB3 A:CYS645 4.3 35.0 1.0
HZ1 A:LYS532 4.4 32.1 1.0
CA A:CYS645 4.5 35.3 1.0
CA A:CYS487 4.5 38.0 1.0
HB3 A:CYS487 4.5 35.1 1.0
CD1 A:PHE571 4.6 33.4 1.0
H A:CYS645 4.6 35.3 1.0
C A:GLY486 4.6 31.6 1.0
HA A:CYS646 4.7 32.4 1.0
O A:HIS642 4.7 34.0 1.0
HA A:CYS487 4.7 35.2 1.0
HE2 A:LYS532 4.7 30.3 1.0
CA A:GLY486 4.8 29.9 1.0
O A:CYS645 4.9 43.0 1.0
C A:HIS642 4.9 32.6 1.0

Reference:

G.I.Small, O.Fedorova, P.D.B.Olinares, J.Chandanani, A.Banerjee, Y.J.Choi, H.Molina, B.T.Chait, S.A.Darst, E.A.Campbell. Structural and Functional Insights Into the Enzymatic Plasticity of the Sars-Cov-2 Niran Domain. Mol.Cell V. 83 3921 2023.
ISSN: ISSN 1097-2765
PubMed: 37890482
DOI: 10.1016/J.MOLCEL.2023.10.001
Page generated: Thu Oct 31 11:07:59 2024

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