Zinc in PDB 8sj2: Structure of Ternary Complex of Cgas with Dsdna and Bound Atp and 2'- Dgtp

All present enzymatic activity of Structure of Ternary Complex of Cgas with Dsdna and Bound Atp and 2'- Dgtp:
2.7.7.86;

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound Atp and 2'- Dgtp, PDB code: 8sj2 was solved by S.Wu, J.Sohn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.72 / 2.23
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	78.634, 98.851, 142.778, 90, 90, 90
R / Rfree (%)	19.9 / 23.4

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound Atp and 2'- Dgtp also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Structure of Ternary Complex of Cgas with Dsdna and Bound Atp and 2'- Dgtp (pdb code 8sj2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Ternary Complex of Cgas with Dsdna and Bound Atp and 2'- Dgtp, PDB code: 8sj2:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound Atp and 2'- Dgtp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Ternary Complex of Cgas with Dsdna and Bound Atp and 2'- Dgtp within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn604 b:38.5 occ:1.00 NE2 A:HIS378 2.0 38.8 1.0 SG A:CYS384 2.3 40.1 1.0 SG A:CYS392 2.3 39.7 1.0 SG A:CYS385 2.4 39.9 1.0 CD2 A:HIS378 2.9 35.8 1.0 CE1 A:HIS378 3.1 38.0 1.0 CB A:CYS392 3.3 40.1 1.0 CB A:CYS385 3.4 37.7 1.0 CB A:CYS384 3.6 37.3 1.0 N A:CYS385 3.7 39.2 1.0 N A:CYS392 3.8 44.5 1.0 C A:CYS384 3.8 40.1 1.0 CA A:CYS392 4.1 43.8 1.0 CA A:CYS385 4.1 42.3 1.0 CG A:HIS378 4.1 37.7 1.0 ND1 A:HIS378 4.2 39.1 1.0 O A:HOH732 4.2 43.2 1.0 CA A:CYS384 4.3 39.7 1.0 O A:CYS384 4.3 38.8 1.0 NH1 A:ARG394 4.4 39.9 1.0 O A:HOH726 4.5 42.9 1.0 C A:CYS392 4.6 44.2 1.0 O A:CYS392 4.7 44.8 1.0 O A:ALA390 4.8 41.2 1.0 C A:LYS391 4.8 45.3 1.0

Zinc binding site 2 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound Atp and 2'- Dgtp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Ternary Complex of Cgas with Dsdna and Bound Atp and 2'- Dgtp within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn604 b:40.9 occ:1.00 NE2 C:HIS378 2.1 39.6 1.0 SG C:CYS385 2.3 38.5 1.0 SG C:CYS392 2.3 39.4 1.0 SG C:CYS384 2.3 39.4 1.0 CD2 C:HIS378 2.9 37.1 1.0 CE1 C:HIS378 3.2 38.2 1.0 CB C:CYS392 3.3 40.0 1.0 CB C:CYS385 3.3 38.8 1.0 CB C:CYS384 3.6 38.4 1.0 N C:CYS385 3.7 39.3 1.0 N C:CYS392 3.8 42.8 1.0 C C:CYS384 3.8 40.5 1.0 CA C:CYS392 4.1 43.7 1.0 CA C:CYS385 4.1 41.9 1.0 CG C:HIS378 4.2 38.8 1.0 O C:HOH735 4.2 40.9 1.0 O C:CYS384 4.2 38.9 1.0 CA C:CYS384 4.2 39.5 1.0 NH1 C:ARG394 4.2 37.4 1.0 ND1 C:HIS378 4.3 36.2 1.0 O C:HOH722 4.6 44.0 1.0 C C:CYS392 4.7 43.8 1.0 C C:LYS391 4.8 42.1 1.0 O C:CYS392 4.8 42.3 1.0 O C:HOH729 4.8 38.8 1.0 O C:ALA390 4.8 43.6 1.0

S.Wu, J.Sohn. Structure of Ternary Complex of Cgas with Dsdna and Bound Atp and 2'-Dgtp To Be Published.