Zinc in PDB 8sj0: Structure of Ternary Complex of Cgas with Dsdna and Bound 2'-Datp

All present enzymatic activity of Structure of Ternary Complex of Cgas with Dsdna and Bound 2'-Datp:
2.7.7.86;

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound 2'-Datp, PDB code: 8sj0 was solved by S.Wu, J.Sohn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.80 / 2.55
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	77.503, 98.3, 143.205, 90, 90, 90
R / Rfree (%)	19.2 / 23.7

The structure of Structure of Ternary Complex of Cgas with Dsdna and Bound 2'-Datp also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Structure of Ternary Complex of Cgas with Dsdna and Bound 2'-Datp (pdb code 8sj0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Ternary Complex of Cgas with Dsdna and Bound 2'-Datp, PDB code: 8sj0:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound 2'-Datp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Ternary Complex of Cgas with Dsdna and Bound 2'-Datp within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn602 b:42.4 occ:1.00 NE2 A:HIS378 2.1 41.8 1.0 SG A:CYS384 2.3 43.4 1.0 SG A:CYS385 2.3 45.9 1.0 SG A:CYS392 2.4 41.9 1.0 CD2 A:HIS378 3.0 39.2 1.0 CE1 A:HIS378 3.1 40.2 1.0 CB A:CYS392 3.2 42.9 1.0 CB A:CYS385 3.4 43.7 1.0 N A:CYS385 3.7 45.0 1.0 CB A:CYS384 3.7 40.8 1.0 C A:CYS384 3.8 46.1 1.0 N A:CYS392 3.8 47.1 1.0 CA A:CYS392 4.0 47.8 1.0 CA A:CYS385 4.1 43.3 1.0 O A:CYS384 4.1 42.9 1.0 ND1 A:HIS378 4.2 41.7 1.0 CG A:HIS378 4.2 44.0 1.0 CA A:CYS384 4.2 43.6 1.0 C A:CYS392 4.5 48.2 1.0 O A:CYS392 4.6 48.4 1.0 O A:ALA390 4.8 50.6 1.0 C A:LYS391 4.8 51.3 1.0

Zinc binding site 2 out of 2 in the Structure of Ternary Complex of Cgas with Dsdna and Bound 2'-Datp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Ternary Complex of Cgas with Dsdna and Bound 2'-Datp within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn602 b:41.9 occ:1.00 NE2 C:HIS378 2.1 47.7 1.0 SG C:CYS385 2.3 53.9 1.0 SG C:CYS384 2.3 46.2 1.0 SG C:CYS392 2.3 46.4 1.0 CD2 C:HIS378 2.9 43.4 1.0 CE1 C:HIS378 3.2 40.5 1.0 CB C:CYS385 3.3 44.9 1.0 CB C:CYS392 3.3 46.3 1.0 CB C:CYS384 3.7 46.5 1.0 N C:CYS385 3.9 46.0 1.0 N C:CYS392 3.9 49.8 1.0 C C:CYS384 3.9 45.1 1.0 CA C:CYS392 4.1 49.9 1.0 CA C:CYS385 4.1 46.2 1.0 CG C:HIS378 4.2 44.4 1.0 ND1 C:HIS378 4.2 40.7 1.0 NH1 C:ARG394 4.3 45.2 1.0 O C:CYS384 4.3 44.0 1.0 CA C:CYS384 4.4 46.8 1.0 C C:CYS392 4.5 52.5 1.0 O C:CYS392 4.6 54.9 1.0 O C:HOH714 4.8 48.6 1.0 C C:LYS391 4.9 52.2 1.0 O C:HOH713 4.9 44.6 1.0 O C:ALA390 5.0 49.8 1.0

S.Wu, J.Sohn. Structure of Ternary Complex of Cgas with Dsdna and Bound 2'-Datp To Be Published.