Zinc in PDB 8qh8: Human Carbonic Anhydrase II in Complex with Lasamide (2,4-Dichloro 5- Sulfamoyl Benzoic Acid)

Enzymatic activity of Human Carbonic Anhydrase II in Complex with Lasamide (2,4-Dichloro 5- Sulfamoyl Benzoic Acid)

All present enzymatic activity of Human Carbonic Anhydrase II in Complex with Lasamide (2,4-Dichloro 5- Sulfamoyl Benzoic Acid):
4.2.1.1;

Protein crystallography data

The structure of Human Carbonic Anhydrase II in Complex with Lasamide (2,4-Dichloro 5- Sulfamoyl Benzoic Acid), PDB code: 8qh8 was solved by C.Baroni, M.Ferraroni, F.Carta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 69.96 / 1.04
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.28, 41.3, 72.22, 90, 104.37, 90
R / Rfree (%) 11.8 / 13.7

Other elements in 8qh8:

The structure of Human Carbonic Anhydrase II in Complex with Lasamide (2,4-Dichloro 5- Sulfamoyl Benzoic Acid) also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human Carbonic Anhydrase II in Complex with Lasamide (2,4-Dichloro 5- Sulfamoyl Benzoic Acid) (pdb code 8qh8). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Carbonic Anhydrase II in Complex with Lasamide (2,4-Dichloro 5- Sulfamoyl Benzoic Acid), PDB code: 8qh8:

Zinc binding site 1 out of 1 in 8qh8

Go back to Zinc Binding Sites List in 8qh8
Zinc binding site 1 out of 1 in the Human Carbonic Anhydrase II in Complex with Lasamide (2,4-Dichloro 5- Sulfamoyl Benzoic Acid)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Carbonic Anhydrase II in Complex with Lasamide (2,4-Dichloro 5- Sulfamoyl Benzoic Acid) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:6.2
occ:1.00
 N11 A:V8I302 1.9 7.5 1.0
NE2 A:HIS94 2.0 6.0 1.0
NE2 A:HIS96 2.0 6.4 1.0
ND1 A:HIS119 2.0 5.9 1.0
CE1 A:HIS119 2.9 6.2 1.0
CD2 A:HIS96 3.0 6.5 1.0
CD2 A:HIS94 3.0 6.3 1.0
CE1 A:HIS94 3.0 6.7 1.0
S10 A:V8I302 3.0 6.7 1.0
O13 A:V8I302 3.0 6.9 1.0
CE1 A:HIS96 3.0 7.4 1.0
CG A:HIS119 3.1 6.0 1.0
CB A:HIS119 3.6 6.6 1.0
OG1 A:THR199 3.9 6.5 1.0
OE1 A:GLU106 3.9 6.9 1.0
C6 A:V8I302 4.0 7.3 1.0
O A:HOH622 4.1 20.6 1.0
C7 A:V8I302 4.1 8.2 1.0
NE2 A:HIS119 4.1 6.6 1.0
ND1 A:HIS94 4.1 6.7 1.0
ND1 A:HIS96 4.2 7.8 1.0
CG A:HIS94 4.2 6.3 1.0
O12 A:V8I302 4.2 7.1 1.0
CG A:HIS96 4.2 6.8 1.0
CD2 A:HIS119 4.2 6.2 1.0
CD A:GLU106 4.9 7.1 1.0

Reference:

C.Baroni, M.Ferraroni, F.Carta. Human Carbonic Anhydrase II in Complex with Lasamide (2,4-Dichloro 5-Sulfamoyl Benzoic Acid) To Be Published.
Page generated: Thu Oct 31 10:04:10 2024

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