Zinc in PDB 8pfp: Crystal Structure of Wrn Helicase Domain in Complex with Atpgammas

All present enzymatic activity of Crystal Structure of Wrn Helicase Domain in Complex with Atpgammas:
3.6.4.12;

The structure of Crystal Structure of Wrn Helicase Domain in Complex with Atpgammas, PDB code: 8pfp was solved by C.Scheufler, F.Villard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.64 / 1.60
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	46.964, 47.707, 55.021, 82.37, 67.15, 63.65
R / Rfree (%)	21.2 / 23.8

The binding sites of Zinc atom in the Crystal Structure of Wrn Helicase Domain in Complex with Atpgammas (pdb code 8pfp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Wrn Helicase Domain in Complex with Atpgammas, PDB code: 8pfp:

Zinc binding site 1 out of 1 in the Crystal Structure of Wrn Helicase Domain in Complex with Atpgammas


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Wrn Helicase Domain in Complex with Atpgammas within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn2001 b:24.7 occ:1.00 SG A:CYS939 2.3 27.4 1.0 SG A:CYS935 2.3 24.2 1.0 SG A:CYS908 2.4 25.9 1.0 SG A:CYS936 2.4 22.6 1.0 CB A:CYS908 3.3 24.1 1.0 CB A:CYS939 3.3 27.3 1.0 CB A:CYS935 3.4 23.4 1.0 CB A:CYS936 3.4 23.2 1.0 CA A:CYS908 3.6 23.8 1.0 N A:CYS936 3.8 22.6 1.0 N A:ARG909 4.0 21.6 1.0 C A:CYS935 4.1 21.8 1.0 C A:CYS908 4.2 23.2 1.0 CA A:CYS936 4.2 22.6 1.0 N A:CYS939 4.3 25.0 1.0 N A:ARG910 4.4 21.0 1.0 CA A:CYS939 4.4 26.1 1.0 N A:GLY931 4.4 28.1 1.0 CA A:CYS935 4.4 23.5 1.0 CB A:ARG910 4.5 22.4 1.0 O A:CYS935 4.7 21.5 1.0 C A:CYS936 4.8 22.6 1.0 O A:CYS936 4.9 22.8 1.0 CA A:MET930 4.9 26.4 1.0 O A:HOH2285 4.9 43.7 1.0 N A:CYS908 4.9 24.7 1.0

H.Moebitz, M.Cortes-Cros, C.Scheufler, J.Hamon, R.Strang, M.Wartmann. Discovery of Wrn Inhibitor HRO761 with Synthetic Lethality in Msi Cancers Nature 2024.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-024-07350-Y