Zinc in PDB 8pc4: Membrane Target Complex 1

All present enzymatic activity of Membrane Target Complex 1:
3.1.4.54;

The structure of Membrane Target Complex 1, PDB code: 8pc4 was solved by G.Garau, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	54.75 / 2.85
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	94.389, 94.389, 442.325, 90, 90, 120
R / Rfree (%)	26.5 / 30.1

The structure of Membrane Target Complex 1 also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Zinc atom in the Membrane Target Complex 1 (pdb code 8pc4). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Membrane Target Complex 1, PDB code: 8pc4:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Membrane Target Complex 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Membrane Target Complex 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:85.5 occ:1.00 O12 A:3PE403 2.0 87.6 1.0 NE2 A:HIS185 2.3 75.2 1.0 ND1 A:HIS187 2.3 85.2 1.0 NE2 A:HIS253 2.3 87.5 1.0 OD2 A:ASP284 2.3 83.7 1.0 ZN A:ZN402 2.9 88.6 1.0 P A:3PE403 2.9 85.1 1.0 CE1 A:HIS253 3.1 88.3 1.0 CE1 A:HIS187 3.2 83.4 1.0 CD2 A:HIS185 3.2 73.7 1.0 CE1 A:HIS185 3.2 76.5 1.0 O14 A:3PE403 3.2 85.8 1.0 CD2 A:HIS253 3.3 87.3 1.0 CG A:HIS187 3.3 82.3 1.0 CG A:ASP284 3.4 83.7 1.0 NE2 A:HIS190 3.4 76.4 1.0 CB A:HIS187 3.6 80.2 1.0 C1 A:3PE403 3.6 91.6 1.0 O11 A:3PE403 3.7 92.3 1.0 CD2 A:HIS190 3.7 78.0 1.0 CB A:ASP284 3.8 83.4 1.0 OD1 A:ASP189 3.9 84.1 1.0 NE2 A:HIS321 4.1 92.3 1.0 ND1 A:HIS253 4.3 88.3 1.0 ND1 A:HIS185 4.3 74.8 1.0 NE2 A:HIS187 4.3 80.7 1.0 CG A:HIS185 4.3 75.2 1.0 CG A:HIS253 4.4 88.3 1.0 OD2 A:ASP189 4.4 84.1 1.0 CD2 A:HIS187 4.4 82.8 1.0 O13 A:3PE403 4.4 94.8 1.0 OD1 A:ASP284 4.5 84.6 1.0 CE1 A:HIS190 4.6 76.8 1.0 CG A:ASP189 4.6 84.0 1.0 CE1 A:HIS321 4.8 90.0 1.0 CG A:HIS190 4.9 79.4 1.0 NE2 A:HIS343 5.0 83.1 1.0

Zinc binding site 2 out of 4 in the Membrane Target Complex 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Membrane Target Complex 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:88.6 occ:1.00 OD2 A:ASP189 2.1 84.1 1.0 OD2 A:ASP284 2.1 83.7 1.0 O14 A:3PE403 2.2 85.8 1.0 NE2 A:HIS190 2.2 76.4 1.0 NE2 A:HIS343 2.3 83.1 1.0 ZN A:ZN401 2.9 85.5 1.0 CG A:ASP189 2.9 84.0 1.0 OD1 A:ASP189 3.1 84.1 1.0 CE1 A:HIS343 3.1 84.3 1.0 CG A:ASP284 3.1 83.7 1.0 CD2 A:HIS190 3.2 78.0 1.0 CE1 A:HIS190 3.2 76.8 1.0 P A:3PE403 3.3 85.1 1.0 OD1 A:ASP284 3.4 84.6 1.0 CD2 A:HIS343 3.5 81.1 1.0 O12 A:3PE403 3.7 87.6 1.0 CD2 A:LEU349 4.0 91.0 1.0 NE2 A:HIS185 4.1 75.2 1.0 NE2 A:HIS321 4.2 92.3 1.0 O11 A:3PE403 4.2 92.3 1.0 ND1 A:HIS190 4.3 77.6 1.0 ND1 A:HIS343 4.3 84.2 1.0 CG A:HIS190 4.3 79.4 1.0 CB A:ASP189 4.3 78.3 1.0 CE1 A:HIS321 4.3 90.0 1.0 CE1 A:HIS185 4.4 76.5 1.0 CB A:ASP284 4.4 83.4 1.0 NE2 A:HIS132 4.5 80.5 1.0 CG A:HIS343 4.5 82.2 1.0 O13 A:3PE403 4.7 94.8 1.0 NE2 A:HIS253 4.8 87.5 1.0 ND1 A:HIS187 4.9 85.2 1.0 CD2 A:HIS132 4.9 82.2 1.0 C1 A:3PE403 5.0 91.6 1.0

Zinc binding site 3 out of 4 in the Membrane Target Complex 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Membrane Target Complex 1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn603 b:82.7 occ:1.00 O12 B:3PE605 2.0 85.9 1.0 NE2 B:HIS185 2.3 74.2 1.0 ND1 B:HIS187 2.3 75.2 1.0 NE2 B:HIS253 2.3 77.5 1.0 OD2 B:ASP284 2.5 78.5 1.0 P B:3PE605 2.9 83.4 1.0 CE1 B:HIS187 3.1 74.5 1.0 ZN B:ZN604 3.2 89.7 1.0 CD2 B:HIS185 3.2 69.3 1.0 CE1 B:HIS185 3.2 71.0 1.0 CE1 B:HIS253 3.2 82.2 1.0 O14 B:3PE605 3.3 82.1 1.0 CG B:HIS187 3.3 78.2 1.0 CD2 B:HIS253 3.3 73.1 1.0 CG B:ASP284 3.5 79.0 1.0 C1 B:3PE605 3.5 84.0 1.0 O11 B:3PE605 3.5 84.4 1.0 CB B:HIS187 3.6 73.2 1.0 CB B:ASP284 3.9 78.5 1.0 NE2 B:HIS190 4.0 74.2 1.0 CD2 B:HIS190 4.1 69.6 1.0 NE2 B:HIS187 4.3 77.0 1.0 OD2 B:ASP189 4.3 76.4 1.0 ND1 B:HIS185 4.3 71.3 1.0 CG B:HIS185 4.3 70.6 1.0 O13 B:3PE605 4.3 86.4 1.0 ND1 B:HIS253 4.3 80.2 1.0 CD2 B:HIS187 4.4 80.8 1.0 CG B:HIS253 4.4 78.8 1.0 OD1 B:ASP189 4.4 72.3 1.0 OD1 B:ASP284 4.5 78.5 1.0 CE1 B:HIS321 4.8 80.8 1.0 CG B:ASP189 4.8 76.5 1.0 NE2 B:HIS321 4.8 82.5 1.0 CE1 B:HIS190 4.9 70.9 1.0 C2 B:3PE605 5.0 85.2 1.0

Zinc binding site 4 out of 4 in the Membrane Target Complex 1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Membrane Target Complex 1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn604 b:89.7 occ:1.00 O14 B:3PE605 1.9 82.1 1.0 OD2 B:ASP284 2.1 78.5 1.0 OD2 B:ASP189 2.2 76.4 1.0 NE2 B:HIS190 2.3 74.2 1.0 NE2 B:HIS343 2.3 79.1 1.0 CE1 B:HIS343 2.9 79.5 1.0 P B:3PE605 3.1 83.4 1.0 CG B:ASP284 3.1 79.0 1.0 CD2 B:HIS190 3.1 69.6 1.0 ZN B:ZN603 3.2 82.7 1.0 CG B:ASP189 3.3 76.5 1.0 CE1 B:HIS190 3.4 70.9 1.0 OD1 B:ASP284 3.5 78.5 1.0 CD2 B:HIS343 3.6 75.9 1.0 O12 B:3PE605 3.7 85.9 1.0 OD1 B:ASP189 3.8 72.3 1.0 NE2 B:HIS132 4.0 68.6 1.0 O11 B:3PE605 4.0 84.4 1.0 CD1 B:LEU349 4.1 81.0 1.0 ND1 B:HIS343 4.2 78.8 1.0 CE1 B:HIS321 4.3 80.8 1.0 O13 B:3PE605 4.3 86.4 1.0 NE2 B:HIS185 4.3 74.2 1.0 CG B:HIS190 4.4 70.6 1.0 ND1 B:HIS190 4.4 72.3 1.0 CB B:ASP284 4.4 78.5 1.0 CE1 B:HIS185 4.4 71.0 1.0 CG B:HIS343 4.5 79.4 1.0 CB B:ASP189 4.5 70.2 1.0 NE2 B:HIS321 4.8 82.5 1.0 CD2 B:HIS132 4.8 71.7 1.0 CE1 B:HIS132 4.9 71.3 1.0 C1 B:3PE605 4.9 84.0 1.0 NE2 B:HIS253 5.0 77.5 1.0

G.Garau, G.Garau. N/A N/A.