Zinc in PDB 8or3: CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1

All present enzymatic activity of CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1:
2.3.2.27; 2.3.2.32;

The binding sites of Zinc atom in the CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 (pdb code 8or3). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1, PDB code: 8or3:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4001 b:77.6 occ:1.00 ND1 B:HIS80 2.3 49.9 1.0 SG B:CYS45 2.3 82.4 1.0 SG B:CYS83 2.3 65.2 1.0 CG B:HIS80 3.0 51.7 1.0 CB B:HIS80 3.1 53.0 1.0 CB B:CYS83 3.4 54.2 1.0 CE1 B:HIS80 3.4 46.1 1.0 SG B:CYS42 3.4 70.7 1.0 CB B:CYS45 3.5 68.7 1.0 CB B:CYS42 3.8 51.7 1.0 N B:CYS45 4.1 70.6 1.0 CD2 B:HIS80 4.2 45.2 1.0 CA B:HIS80 4.3 39.4 1.0 N B:HIS80 4.3 38.4 1.0 NE2 B:HIS80 4.3 46.1 1.0 CA B:CYS45 4.4 70.1 1.0 CG2 B:ILE44 4.6 58.2 1.0 CB B:CYS53 4.6 67.6 1.0 O B:CYS45 4.6 81.0 1.0 CB B:ILE44 4.7 51.9 1.0 CA B:CYS83 4.7 49.9 1.0 N B:CYS83 5.0 49.1 1.0 C B:CYS45 5.0 73.4 1.0

Zinc binding site 2 out of 3 in the CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4002 b:95.5 occ:1.00 OD2 B:ASP97 2.0 76.7 1.0 CG B:ASP97 2.2 77.3 1.0 SG B:CYS75 2.3 61.5 1.0 ND1 B:HIS77 2.3 53.3 1.0 SG B:CYS94 2.3 59.8 1.0 OD1 B:ASP97 2.5 81.3 1.0 CE1 B:HIS77 2.7 50.7 1.0 CB B:CYS94 3.0 51.5 1.0 CB B:ASP97 3.3 68.6 1.0 CB B:CYS75 3.4 59.3 1.0 CG B:HIS77 3.6 53.0 1.0 N B:ASP97 3.9 64.4 1.0 NE2 B:HIS77 3.9 46.5 1.0 CA B:ASP97 4.2 63.0 1.0 CB B:HIS77 4.3 50.1 1.0 CD2 B:HIS77 4.4 47.4 1.0 CA B:CYS94 4.4 49.9 1.0 CE3 B:TRP101 4.7 49.1 1.0 C B:CYS94 4.7 55.9 1.0 O B:CYS94 4.8 59.7 1.0 CA B:CYS75 4.8 53.4 1.0 NE B:ARG99 4.9 69.6 1.0 CZ3 B:TRP101 4.9 46.0 1.0 CG B:ARG99 4.9 63.9 1.0 C B:ASP97 4.9 64.1 1.0 C B:LEU96 5.0 62.4 1.0

Zinc binding site 3 out of 3 in the CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4003 b:87.3 occ:1.00 SG B:CYS56 2.3 85.9 1.0 SG B:CYS53 2.3 77.1 1.0 SG B:CYS68 2.3 75.7 1.0 CB B:CYS53 2.6 67.6 1.0 CB B:CYS68 2.9 62.0 1.0 CB B:CYS56 3.4 77.3 1.0 N B:CYS53 3.4 62.5 1.0 CD2 B:HIS82 3.6 52.9 1.0 CA B:CYS53 3.6 64.8 1.0 CA B:CYS68 4.0 64.0 1.0 CG B:HIS82 4.1 59.8 1.0 CB B:HIS82 4.1 54.2 1.0 NE2 B:HIS82 4.6 53.8 1.0 C B:CYS53 4.6 68.7 1.0 C B:LEU52 4.7 51.3 1.0 CA B:CYS56 4.7 75.4 1.0 N B:CYS56 4.7 75.5 1.0 C B:CYS68 5.0 67.5 1.0 N B:CYS68 5.0 60.1 1.0

M.Shaaban, J.A.Clapperton, S.Ding, S.Kunzelmann, M.E.Maeots, S.L.Maslen, J.M.Skehel, R.I.Enchev. Structural and Mechanistic Insights Into the CAND1-Mediated Scf Substrate Receptor Exchange. Mol.Cell 2023.
ISSN: ISSN 1097-2765
PubMed: 37339624
DOI: 10.1016/J.MOLCEL.2023.05.034