Zinc in PDB 8or3: CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1
Enzymatic activity of CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1
All present enzymatic activity of CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1:
2.3.2.27;
2.3.2.32;
Zinc Binding Sites:
The binding sites of Zinc atom in the CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1
(pdb code 8or3). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the
CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1, PDB code: 8or3:
Jump to Zinc binding site number:
1;
2;
3;
Zinc binding site 1 out
of 3 in 8or3
Go back to
Zinc Binding Sites List in 8or3
Zinc binding site 1 out
of 3 in the CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1
![](/pictures/ZN/pdb/or/8or3-ZN-sphere_01.jpg) Mono view
![](/pictures/ZN/pdb/or/8or3-ZN-sphere_01_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn4001
b:77.6
occ:1.00
|
ND1
|
B:HIS80
|
2.3
|
49.9
|
1.0
|
SG
|
B:CYS45
|
2.3
|
82.4
|
1.0
|
SG
|
B:CYS83
|
2.3
|
65.2
|
1.0
|
CG
|
B:HIS80
|
3.0
|
51.7
|
1.0
|
CB
|
B:HIS80
|
3.1
|
53.0
|
1.0
|
CB
|
B:CYS83
|
3.4
|
54.2
|
1.0
|
CE1
|
B:HIS80
|
3.4
|
46.1
|
1.0
|
SG
|
B:CYS42
|
3.4
|
70.7
|
1.0
|
CB
|
B:CYS45
|
3.5
|
68.7
|
1.0
|
CB
|
B:CYS42
|
3.8
|
51.7
|
1.0
|
N
|
B:CYS45
|
4.1
|
70.6
|
1.0
|
CD2
|
B:HIS80
|
4.2
|
45.2
|
1.0
|
CA
|
B:HIS80
|
4.3
|
39.4
|
1.0
|
N
|
B:HIS80
|
4.3
|
38.4
|
1.0
|
NE2
|
B:HIS80
|
4.3
|
46.1
|
1.0
|
CA
|
B:CYS45
|
4.4
|
70.1
|
1.0
|
CG2
|
B:ILE44
|
4.6
|
58.2
|
1.0
|
CB
|
B:CYS53
|
4.6
|
67.6
|
1.0
|
O
|
B:CYS45
|
4.6
|
81.0
|
1.0
|
CB
|
B:ILE44
|
4.7
|
51.9
|
1.0
|
CA
|
B:CYS83
|
4.7
|
49.9
|
1.0
|
N
|
B:CYS83
|
5.0
|
49.1
|
1.0
|
C
|
B:CYS45
|
5.0
|
73.4
|
1.0
|
|
Zinc binding site 2 out
of 3 in 8or3
Go back to
Zinc Binding Sites List in 8or3
Zinc binding site 2 out
of 3 in the CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1
![](/pictures/ZN/pdb/or/8or3-ZN-sphere_02.jpg) Mono view
![](/pictures/ZN/pdb/or/8or3-ZN-sphere_02_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn4002
b:95.5
occ:1.00
|
OD2
|
B:ASP97
|
2.0
|
76.7
|
1.0
|
CG
|
B:ASP97
|
2.2
|
77.3
|
1.0
|
SG
|
B:CYS75
|
2.3
|
61.5
|
1.0
|
ND1
|
B:HIS77
|
2.3
|
53.3
|
1.0
|
SG
|
B:CYS94
|
2.3
|
59.8
|
1.0
|
OD1
|
B:ASP97
|
2.5
|
81.3
|
1.0
|
CE1
|
B:HIS77
|
2.7
|
50.7
|
1.0
|
CB
|
B:CYS94
|
3.0
|
51.5
|
1.0
|
CB
|
B:ASP97
|
3.3
|
68.6
|
1.0
|
CB
|
B:CYS75
|
3.4
|
59.3
|
1.0
|
CG
|
B:HIS77
|
3.6
|
53.0
|
1.0
|
N
|
B:ASP97
|
3.9
|
64.4
|
1.0
|
NE2
|
B:HIS77
|
3.9
|
46.5
|
1.0
|
CA
|
B:ASP97
|
4.2
|
63.0
|
1.0
|
CB
|
B:HIS77
|
4.3
|
50.1
|
1.0
|
CD2
|
B:HIS77
|
4.4
|
47.4
|
1.0
|
CA
|
B:CYS94
|
4.4
|
49.9
|
1.0
|
CE3
|
B:TRP101
|
4.7
|
49.1
|
1.0
|
C
|
B:CYS94
|
4.7
|
55.9
|
1.0
|
O
|
B:CYS94
|
4.8
|
59.7
|
1.0
|
CA
|
B:CYS75
|
4.8
|
53.4
|
1.0
|
NE
|
B:ARG99
|
4.9
|
69.6
|
1.0
|
CZ3
|
B:TRP101
|
4.9
|
46.0
|
1.0
|
CG
|
B:ARG99
|
4.9
|
63.9
|
1.0
|
C
|
B:ASP97
|
4.9
|
64.1
|
1.0
|
C
|
B:LEU96
|
5.0
|
62.4
|
1.0
|
|
Zinc binding site 3 out
of 3 in 8or3
Go back to
Zinc Binding Sites List in 8or3
Zinc binding site 3 out
of 3 in the CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1
![](/pictures/ZN/pdb/or/8or3-ZN-sphere_03.jpg) Mono view
![](/pictures/ZN/pdb/or/8or3-ZN-sphere_03_stereo.jpg) Stereo pair view
|
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Zn4003
b:87.3
occ:1.00
|
SG
|
B:CYS56
|
2.3
|
85.9
|
1.0
|
SG
|
B:CYS53
|
2.3
|
77.1
|
1.0
|
SG
|
B:CYS68
|
2.3
|
75.7
|
1.0
|
CB
|
B:CYS53
|
2.6
|
67.6
|
1.0
|
CB
|
B:CYS68
|
2.9
|
62.0
|
1.0
|
CB
|
B:CYS56
|
3.4
|
77.3
|
1.0
|
N
|
B:CYS53
|
3.4
|
62.5
|
1.0
|
CD2
|
B:HIS82
|
3.6
|
52.9
|
1.0
|
CA
|
B:CYS53
|
3.6
|
64.8
|
1.0
|
CA
|
B:CYS68
|
4.0
|
64.0
|
1.0
|
CG
|
B:HIS82
|
4.1
|
59.8
|
1.0
|
CB
|
B:HIS82
|
4.1
|
54.2
|
1.0
|
NE2
|
B:HIS82
|
4.6
|
53.8
|
1.0
|
C
|
B:CYS53
|
4.6
|
68.7
|
1.0
|
C
|
B:LEU52
|
4.7
|
51.3
|
1.0
|
CA
|
B:CYS56
|
4.7
|
75.4
|
1.0
|
N
|
B:CYS56
|
4.7
|
75.5
|
1.0
|
C
|
B:CYS68
|
5.0
|
67.5
|
1.0
|
N
|
B:CYS68
|
5.0
|
60.1
|
1.0
|
|
Reference:
M.Shaaban,
J.A.Clapperton,
S.Ding,
S.Kunzelmann,
M.E.Maeots,
S.L.Maslen,
J.M.Skehel,
R.I.Enchev.
Structural and Mechanistic Insights Into the CAND1-Mediated Scf Substrate Receptor Exchange. Mol.Cell 2023.
ISSN: ISSN 1097-2765
PubMed: 37339624
DOI: 10.1016/J.MOLCEL.2023.05.034
Page generated: Fri Jul 28 07:18:01 2023
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