Zinc in PDB 8or2: CAND1-CUL1-RBX1-DCNL1

All present enzymatic activity of CAND1-CUL1-RBX1-DCNL1:
2.3.2.27; 2.3.2.32;

The binding sites of Zinc atom in the CAND1-CUL1-RBX1-DCNL1 (pdb code 8or2). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the CAND1-CUL1-RBX1-DCNL1, PDB code: 8or2:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the CAND1-CUL1-RBX1-DCNL1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of CAND1-CUL1-RBX1-DCNL1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4001 b:69.5 occ:1.00 ND1 B:HIS80 2.3 53.7 1.0 SG B:CYS45 2.3 56.5 1.0 SG B:CYS83 2.3 54.5 1.0 CB B:HIS80 2.7 53.7 1.0 CG B:HIS80 2.8 53.7 1.0 CB B:CYS83 2.8 54.5 1.0 SG B:CYS42 3.4 54.7 1.0 CE1 B:HIS80 3.4 53.7 1.0 CB B:CYS45 3.5 56.5 1.0 N B:HIS80 3.5 53.7 1.0 CA B:HIS80 3.7 53.7 1.0 CD2 B:HIS80 4.0 53.7 1.0 N B:CYS45 4.0 56.5 1.0 CA B:CYS83 4.3 54.5 1.0 NE2 B:HIS80 4.3 53.7 1.0 CB B:CYS42 4.3 54.7 1.0 CA B:CYS45 4.4 56.5 1.0 CB B:ILE44 4.4 53.9 1.0 C B:HIS80 4.5 53.7 1.0 N B:CYS83 4.6 54.5 1.0 O B:HIS80 4.6 53.7 1.0 C B:PHE79 4.7 52.8 1.0 CG2 B:ILE44 5.0 53.9 1.0 C B:ILE44 5.0 53.9 1.0

Zinc binding site 2 out of 3 in the CAND1-CUL1-RBX1-DCNL1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of CAND1-CUL1-RBX1-DCNL1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4002 b:63.2 occ:1.00 ND1 B:HIS77 2.3 52.3 1.0 SG B:CYS94 2.3 53.9 1.0 SG B:CYS75 2.3 53.9 1.0 CE1 B:HIS77 3.1 52.3 1.0 CB B:CYS94 3.2 53.9 1.0 CG B:HIS77 3.4 52.3 1.0 OD1 B:ASP97 3.5 55.1 1.0 CB B:CYS75 3.5 53.9 1.0 OD2 B:ASP97 3.7 55.1 1.0 CG B:ASP97 3.8 55.1 1.0 CE3 B:TRP101 3.8 51.7 1.0 CB B:HIS77 3.8 52.3 1.0 CZ3 B:TRP101 3.8 51.7 1.0 NE2 B:HIS77 4.3 52.3 1.0 CB B:LEU96 4.4 54.8 1.0 CE2 B:PHE79 4.4 52.8 1.0 CD1 B:LEU96 4.4 54.8 1.0 CD2 B:HIS77 4.5 52.3 1.0 CA B:CYS94 4.7 53.9 1.0 N B:ASP97 4.7 55.1 1.0 CB B:ASP97 4.9 55.1 1.0 CA B:CYS75 4.9 53.9 1.0 CG B:LEU96 4.9 54.8 1.0

Zinc binding site 3 out of 3 in the CAND1-CUL1-RBX1-DCNL1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of CAND1-CUL1-RBX1-DCNL1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4003 b:73.0 occ:1.00 SG B:CYS56 2.3 60.3 1.0 SG B:CYS68 2.3 55.9 1.0 SG B:CYS53 2.3 58.3 1.0 CB B:CYS68 2.5 55.9 1.0 CB B:CYS56 3.1 60.3 1.0 CB B:CYS53 3.1 58.3 1.0 N B:CYS53 3.2 58.3 1.0 CA B:CYS53 3.7 58.3 1.0 CA B:CYS68 4.0 55.9 1.0 CD2 B:HIS82 4.3 54.5 1.0 C B:LEU52 4.3 58.7 1.0 CA B:CYS56 4.3 60.3 1.0 N B:CYS56 4.4 60.3 1.0 CA B:LEU52 4.5 58.7 1.0 C B:CYS53 4.5 58.3 1.0 O B:CYS53 4.6 58.3 1.0 C B:CYS68 4.7 55.9 1.0 O B:CYS68 4.7 55.9 1.0 N B:CYS68 4.8 55.9 1.0 CB B:LEU52 4.8 58.7 1.0 NE2 B:HIS82 4.8 54.5 1.0 CG B:HIS82 4.9 54.5 1.0

M.Shaaban, J.A.Clapperton, S.Ding, S.Kunzelmann, M.E.Maeots, S.L.Maslen, J.M.Skehel, R.I.Enchev. Structural and Mechanistic Insights Into the CAND1-Mediated Scf Substrate Receptor Exchange. Mol.Cell 2023.
ISSN: ISSN 1097-2765
PubMed: 37339624
DOI: 10.1016/J.MOLCEL.2023.05.034