Zinc in PDB 8or0: CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2

All present enzymatic activity of CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2:
2.3.2.27; 2.3.2.32; 2.7.11.22;

The binding sites of Zinc atom in the CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 (pdb code 8or0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2, PDB code: 8or0:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in the CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4001 b:49.5 occ:1.00 SG B:CYS45 2.3 97.5 1.0 ND1 B:HIS80 2.3 78.8 1.0 SG B:CYS83 2.3 46.5 1.0 CG B:HIS80 3.1 71.1 1.0 CE1 B:HIS80 3.1 76.8 1.0 CB B:HIS80 3.5 71.0 1.0 SG B:CYS42 3.6 114.2 1.0 CB B:CYS83 3.6 53.6 1.0 CB B:CYS45 3.9 93.7 1.0 CB B:CYS53 4.0 108.3 1.0 NE2 B:HIS80 4.0 72.2 1.0 CD2 B:HIS80 4.1 65.6 1.0 N B:CYS45 4.6 85.5 1.0 CA B:HIS80 4.7 67.7 1.0 N B:HIS80 4.7 73.8 1.0 CA B:CYS45 4.8 91.0 1.0 CB B:CYS42 4.8 108.0 1.0 CA B:CYS53 4.9 108.8 1.0 CA B:CYS83 4.9 49.8 1.0 O B:CYS45 5.0 85.1 1.0 SG B:CYS53 5.0 109.5 1.0

Zinc binding site 2 out of 3 in the CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4002 b:77.8 occ:1.00 SG B:CYS75 2.3 58.8 1.0 ND1 B:HIS77 2.3 68.9 1.0 SG B:CYS94 2.3 75.8 1.0 OD2 B:ASP97 2.4 73.8 1.0 CG B:HIS77 3.0 69.0 1.0 CE1 B:HIS77 3.0 64.0 1.0 CG B:ASP97 3.2 73.2 1.0 CB B:ASP97 3.4 71.2 1.0 CB B:HIS77 3.5 64.9 1.0 CB B:CYS75 3.6 46.2 1.0 CB B:CYS94 3.6 57.8 1.0 NE2 B:HIS77 3.9 60.2 1.0 CD2 B:HIS77 3.9 63.4 1.0 CZ3 B:TRP101 4.1 51.4 1.0 OD1 B:ASP97 4.3 74.4 1.0 CE3 B:TRP101 4.6 44.7 1.0 CA B:ASP97 4.7 63.7 1.0 CA B:CYS75 4.9 39.8 1.0 CA B:HIS77 4.9 64.5 1.0 N B:ASP97 4.9 59.2 1.0 CA B:CYS94 5.0 39.9 1.0

Zinc binding site 3 out of 3 in the CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn4003 b:79.1 occ:1.00 ND1 B:HIS82 2.1 71.2 1.0 SG B:CYS56 2.3 118.3 1.0 SG B:CYS53 2.3 109.5 1.0 SG B:CYS68 2.3 92.4 1.0 CE1 B:HIS82 3.0 67.1 1.0 CG B:HIS82 3.1 70.1 1.0 OE2 B:GLU55 3.2 99.1 1.0 CB B:CYS56 3.3 110.7 1.0 CB B:HIS82 3.4 68.9 1.0 CB B:CYS68 3.7 89.9 1.0 CB B:CYS53 4.1 108.3 1.0 NE2 B:HIS82 4.1 68.7 1.0 CD1 B:LEU52 4.1 107.0 1.0 CD2 B:HIS82 4.2 71.7 1.0 CD B:GLU55 4.2 99.7 1.0 CA B:CYS56 4.5 109.0 1.0 N B:CYS56 4.7 108.5 1.0 CA B:HIS82 4.7 69.4 1.0 N B:HIS82 4.8 68.2 1.0 OE1 B:GLU55 4.8 101.0 1.0 CA B:CYS68 5.0 89.3 1.0

M.Shaaban, J.A.Clapperton, S.Ding, S.Kunzelmann, M.E.Maeots, S.L.Maslen, J.M.Skehel, R.I.Enchev. Structural and Mechanistic Insights Into the CAND1-Mediated Scf Substrate Receptor Exchange. Mol.Cell 2023.
ISSN: ISSN 1097-2765
PubMed: 37339624
DOI: 10.1016/J.MOLCEL.2023.05.034