Zinc in PDB 8opt: Human Terminal Uridylyltransferase 7 (TUT7/ZCCHC6) Bound with Pre- LET7G Mirna and LIN28A - Complex 2

All present enzymatic activity of Human Terminal Uridylyltransferase 7 (TUT7/ZCCHC6) Bound with Pre- LET7G Mirna and LIN28A - Complex 2:
2.7.7.52;

The binding sites of Zinc atom in the Human Terminal Uridylyltransferase 7 (TUT7/ZCCHC6) Bound with Pre- LET7G Mirna and LIN28A - Complex 2 (pdb code 8opt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human Terminal Uridylyltransferase 7 (TUT7/ZCCHC6) Bound with Pre- LET7G Mirna and LIN28A - Complex 2, PDB code: 8opt:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human Terminal Uridylyltransferase 7 (TUT7/ZCCHC6) Bound with Pre- LET7G Mirna and LIN28A - Complex 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Terminal Uridylyltransferase 7 (TUT7/ZCCHC6) Bound with Pre- LET7G Mirna and LIN28A - Complex 2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1501 b:79.2 occ:1.00 HE1 A:HIS973 1.1 74.3 1.0 CE1 A:HIS973 1.7 74.3 1.0 HD1 A:HIS973 2.0 74.3 1.0 ND1 A:HIS973 2.1 74.3 1.0 SG A:CYS978 2.3 71.3 1.0 SG A:CYS968 2.3 79.0 1.0 SG A:CYS965 2.3 76.4 1.0 NE2 A:HIS973 2.9 74.3 1.0 HB2 A:CYS968 3.1 79.0 1.0 HB3 A:CYS965 3.3 76.4 1.0 CB A:CYS968 3.3 79.0 1.0 CB A:CYS965 3.4 76.4 1.0 HE2 A:HIS973 3.4 74.3 1.0 CG A:HIS973 3.4 74.3 1.0 HB2 A:CYS965 3.6 76.4 1.0 HB2 A:CYS978 3.7 71.3 1.0 H A:CYS968 3.7 79.0 1.0 CB A:CYS978 3.7 71.3 1.0 HD22 A:LEU967 3.7 71.6 1.0 CD2 A:HIS973 3.8 74.3 1.0 HB2 A:GLU980 4.0 65.7 1.0 HB3 A:CYS968 4.0 79.0 1.0 HB3 A:LEU967 4.0 71.6 1.0 HB3 A:CYS978 4.1 71.3 1.0 N A:CYS968 4.2 79.0 1.0 HD2 A:PRO979 4.3 68.7 1.0 H A:GLU980 4.4 65.7 1.0 CA A:CYS968 4.4 79.0 1.0 HB2 A:ARG970 4.4 87.3 1.0 HD23 A:LEU967 4.4 71.6 1.0 HB2 A:HIS973 4.4 74.3 1.0 CD2 A:LEU967 4.5 71.6 1.0 CB A:HIS973 4.6 74.3 1.0 O A:HIS973 4.6 74.3 1.0 HD2 A:HIS973 4.7 74.3 1.0 HG3 A:GLU980 4.7 65.7 1.0 CA A:CYS965 4.8 76.4 1.0 CB A:GLU980 4.9 65.7 1.0 HA A:CYS978 4.9 71.3 1.0 CA A:CYS978 4.9 71.3 1.0 CB A:LEU967 4.9 71.6 1.0 H A:ARG970 5.0 87.3 1.0

Zinc binding site 2 out of 2 in the Human Terminal Uridylyltransferase 7 (TUT7/ZCCHC6) Bound with Pre- LET7G Mirna and LIN28A - Complex 2


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human Terminal Uridylyltransferase 7 (TUT7/ZCCHC6) Bound with Pre- LET7G Mirna and LIN28A - Complex 2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn301 b:154.1 occ:1.00 HB2 B:CYS139 2.1 101.2 1.0 SG B:CYS152 2.3 98.6 1.0 SG B:CYS139 2.3 101.2 1.0 SG B:CYS142 2.3 103.5 1.0 CB B:CYS139 2.4 101.2 1.0 O B:ASN141 2.5 98.1 1.0 HB3 B:CYS139 2.6 101.2 1.0 H B:GLY144 3.0 103.2 1.0 HD21 B:LEU154 3.2 102.6 1.0 HB2 B:CYS152 3.4 98.6 1.0 CB B:CYS152 3.5 98.6 1.0 HB3 B:CYS142 3.6 103.5 1.0 HA3 B:GLY144 3.6 103.2 1.0 CB B:CYS142 3.6 103.5 1.0 C B:ASN141 3.7 98.1 1.0 N B:GLY144 3.8 103.2 1.0 HB3 B:CYS152 3.9 98.6 1.0 CA B:CYS139 3.9 101.2 1.0 HD23 B:LEU154 4.0 102.6 1.0 CD2 B:LEU154 4.0 102.6 1.0 CA B:GLY144 4.1 103.2 1.0 H B:CYS139 4.1 101.2 1.0 H B:ASN141 4.3 98.1 1.0 HB2 B:HIS147 4.4 93.3 1.0 HB2 B:CYS142 4.4 103.5 1.0 CA B:CYS142 4.4 103.5 1.0 H B:GLY143 4.4 105.4 1.0 N B:CYS142 4.4 103.5 1.0 HA B:CYS139 4.5 101.2 1.0 C B:CYS142 4.5 103.5 1.0 N B:GLY143 4.5 105.4 1.0 N B:CYS139 4.5 101.2 1.0 C B:GLY144 4.6 103.2 1.0 HG B:LEU154 4.6 102.6 1.0 O B:GLY144 4.6 103.2 1.0 C B:CYS139 4.6 101.2 1.0 HD22 B:LEU154 4.7 102.6 1.0 HA B:CYS152 4.7 98.6 1.0 H B:HIS147 4.8 93.3 1.0 CA B:CYS152 4.8 98.6 1.0 HB2 B:ASN141 4.8 98.1 1.0 CA B:ASN141 4.8 98.1 1.0 N B:ASN141 4.8 98.1 1.0 CG B:LEU154 4.9 102.6 1.0 O B:CYS139 4.9 101.2 1.0 C B:GLY143 4.9 105.4 1.0 HA2 B:GLY144 5.0 103.2 1.0

G.Yi, M.Ye, L.Carrique, A.El-Sagheer, T.Brown, C.J.Norbury, P.Zhang, R.J.C.Gilbert. Structural Basis For Activity Switching in Polymerases Determining the Fate of Let-7 Pre-Mirnas Nat.Struct.Biol. 2024.
ISSN: ISSN 1072-8368
DOI: 10.1038/S41594-024-01357-9