Zinc in PDB 8k72: Factor-Inhibiting Hypoxia-Inducible Factor in Complex with Zn(II) and 2-(3-Hydroxy-2-((3-(Phenylsulfonamido)Propanoyl)Imino)-2,3- Dihydrothiazol-4-Yl)Acetic Acid

Enzymatic activity of Factor-Inhibiting Hypoxia-Inducible Factor in Complex with Zn(II) and 2-(3-Hydroxy-2-((3-(Phenylsulfonamido)Propanoyl)Imino)-2,3- Dihydrothiazol-4-Yl)Acetic Acid

All present enzymatic activity of Factor-Inhibiting Hypoxia-Inducible Factor in Complex with Zn(II) and 2-(3-Hydroxy-2-((3-(Phenylsulfonamido)Propanoyl)Imino)-2,3- Dihydrothiazol-4-Yl)Acetic Acid:
1.14.11.30;

Protein crystallography data

The structure of Factor-Inhibiting Hypoxia-Inducible Factor in Complex with Zn(II) and 2-(3-Hydroxy-2-((3-(Phenylsulfonamido)Propanoyl)Imino)-2,3- Dihydrothiazol-4-Yl)Acetic Acid, PDB code: 8k72 was solved by Y.Nakashima, T.P.Corner, R.Z.R.Teo, L.Brewitz, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 61.24 / 2.45
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.61, 86.61, 145.05, 90, 90, 90
R / Rfree (%) 20 / 23.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor-Inhibiting Hypoxia-Inducible Factor in Complex with Zn(II) and 2-(3-Hydroxy-2-((3-(Phenylsulfonamido)Propanoyl)Imino)-2,3- Dihydrothiazol-4-Yl)Acetic Acid (pdb code 8k72). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor-Inhibiting Hypoxia-Inducible Factor in Complex with Zn(II) and 2-(3-Hydroxy-2-((3-(Phenylsulfonamido)Propanoyl)Imino)-2,3- Dihydrothiazol-4-Yl)Acetic Acid, PDB code: 8k72:

Zinc binding site 1 out of 1 in 8k72

Go back to Zinc Binding Sites List in 8k72
Zinc binding site 1 out of 1 in the Factor-Inhibiting Hypoxia-Inducible Factor in Complex with Zn(II) and 2-(3-Hydroxy-2-((3-(Phenylsulfonamido)Propanoyl)Imino)-2,3- Dihydrothiazol-4-Yl)Acetic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor-Inhibiting Hypoxia-Inducible Factor in Complex with Zn(II) and 2-(3-Hydroxy-2-((3-(Phenylsulfonamido)Propanoyl)Imino)-2,3- Dihydrothiazol-4-Yl)Acetic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn409

b:69.1
occ:1.00
 O01 A:VJF410 1.9 74.6 1.0
OD2 A:ASP201 2.0 98.8 1.0
NE2 A:HIS279 2.3 68.8 1.0
NE2 A:HIS199 2.3 68.4 1.0
N11 A:VJF410 2.5 90.4 1.0
N02 A:VJF410 2.6 76.9 1.0
CG A:ASP201 2.7 87.9 1.0
OD1 A:ASP201 2.8 89.5 1.0
C10 A:VJF410 2.9 83.3 1.0
CE1 A:HIS279 3.2 69.0 1.0
CE1 A:HIS199 3.2 71.0 1.0
CD2 A:HIS199 3.3 68.8 1.0
CD2 A:HIS279 3.4 69.7 1.0
O A:HOH515 3.7 84.2 1.0
C12 A:VJF410 3.8 94.4 1.0
O A:HOH512 3.8 88.6 1.0
CH2 A:TRP296 4.0 79.5 0.5
CB A:ASP201 4.1 81.1 1.0
C13 A:VJF410 4.1 94.9 1.0
ND1 A:HIS199 4.3 69.5 1.0
C03 A:VJF410 4.3 75.9 1.0
CG A:HIS199 4.3 69.1 1.0
O A:HOH546 4.3 91.8 1.0
ND1 A:HIS279 4.4 70.6 1.0
CZ2 A:TRP296 4.4 80.3 0.5
C14 A:VJF410 4.5 97.5 1.0
CG A:HIS279 4.5 68.9 1.0
S09 A:VJF410 4.6 82.6 1.0
CZ3 A:TRP296 4.7 78.2 0.5
O25 A:VJF410 4.8 98.8 1.0
CZ2 A:TRP296 4.9 80.7 0.5
N A:ASP201 5.0 75.8 1.0

Reference:

T.P.Corner, R.Z.R.Teo, Y.Wu, E.Salah, Y.Nakashima, G.Fiorini, A.Tumber, A.Brasnett, J.P.Holt-Martyn, W.D.Figg Jr., X.Zhang, L.Brewitz, C.J.Schofield. Structure-Guided Optimisation of N -Hydroxythiazole-Derived Inhibitors of Factor Inhibiting Hypoxia-Inducible Factor-Alpha. Chem Sci V. 14 12098 2023.
ISSN: ISSN 2041-6520
PubMed: 37969593
DOI: 10.1039/D3SC04253G
Page generated: Thu Oct 31 08:37:16 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy