Zinc in PDB 8jrr: Structure of E6AP-E6 Complex in DET2 State

Enzymatic activity of Structure of E6AP-E6 Complex in DET2 State

All present enzymatic activity of Structure of E6AP-E6 Complex in DET2 State:
2.3.2.26;

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of E6AP-E6 Complex in DET2 State (pdb code 8jrr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of E6AP-E6 Complex in DET2 State, PDB code: 8jrr:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 8jrr

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Zinc binding site 1 out of 4 in the Structure of E6AP-E6 Complex in DET2 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of E6AP-E6 Complex in DET2 State within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn201

b:161.1
occ:1.00
 SG B:CYS70 2.5 162.3 1.0
CB B:TYR39 2.5 162.4 1.0
SG B:CYS37 2.5 178.2 1.0
CB B:CYS73 2.6 146.4 1.0
SG B:CYS73 2.6 146.4 1.0
N B:CYS40 2.8 182.7 1.0
CA B:TYR39 3.3 162.4 1.0
C B:TYR39 3.4 162.4 1.0
CG B:TYR39 3.4 162.4 1.0
CD2 B:TYR39 3.5 162.4 1.0
N B:TYR39 3.6 162.4 1.0
CB B:CYS40 3.7 182.7 1.0
CA B:CYS40 3.8 182.7 1.0
CB B:CYS37 3.8 178.2 1.0
N B:CYS70 3.9 162.3 1.0
CA B:CYS73 4.0 146.4 1.0
CB B:CYS70 4.0 162.3 1.0
SG B:CYS40 4.1 182.7 1.0
N B:CYS73 4.4 146.4 1.0
CA B:CYS70 4.5 162.3 1.0
O B:TYR39 4.5 162.4 1.0
O B:CYS70 4.6 162.3 1.0
CD1 B:TYR39 4.8 162.4 1.0
CG2 B:VAL69 4.8 157.2 1.0
CE2 B:TYR39 4.8 162.4 1.0
CE2 B:TYR77 4.8 125.6 1.0
C B:CYS73 4.8 146.4 1.0
C B:VAL38 4.9 169.1 1.0
C B:CYS70 4.9 162.3 1.0
C B:VAL69 4.9 157.2 1.0

Zinc binding site 2 out of 4 in 8jrr

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Zinc binding site 2 out of 4 in the Structure of E6AP-E6 Complex in DET2 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of E6AP-E6 Complex in DET2 State within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn202

b:228.3
occ:1.00
 SG B:CYS113 2.5 162.9 1.0
SG B:CYS143 2.9 192.5 1.0
SG B:CYS146 3.0 186.4 1.0
CB B:CYS113 3.2 162.9 1.0
SG B:CYS110 3.2 165.3 1.0
N B:CYS113 3.5 162.9 1.0
CB B:CYS146 3.6 186.4 1.0
CB B:ASN112 3.7 156.3 1.0
N B:CYS146 3.9 186.4 1.0
CA B:CYS113 3.9 162.9 1.0
C B:ASN112 4.1 156.3 1.0
CB B:CYS143 4.1 192.5 1.0
CB B:SER145 4.3 184.9 1.0
CB B:CYS110 4.3 165.3 1.0
CA B:ASN112 4.4 156.3 1.0
CA B:CYS146 4.4 186.4 1.0
C B:SER145 4.5 184.9 1.0
NH2 B:ARG55 4.6 156.1 1.0
N B:ASN112 4.7 156.3 1.0
N B:CYS143 4.8 192.5 1.0
CA B:SER145 4.8 184.9 1.0
CG B:ASN112 4.9 156.3 1.0
C B:CYS113 4.9 162.9 1.0
CA B:CYS143 5.0 192.5 1.0

Zinc binding site 3 out of 4 in 8jrr

Go back to Zinc Binding Sites List in 8jrr
Zinc binding site 3 out of 4 in the Structure of E6AP-E6 Complex in DET2 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of E6AP-E6 Complex in DET2 State within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn201

b:161.1
occ:1.00
 SG D:CYS70 2.5 162.3 1.0
CB D:TYR39 2.5 162.4 1.0
SG D:CYS37 2.5 178.2 1.0
CB D:CYS73 2.6 146.4 1.0
SG D:CYS73 2.6 146.4 1.0
N D:CYS40 2.8 182.7 1.0
CA D:TYR39 3.3 162.4 1.0
C D:TYR39 3.4 162.4 1.0
CG D:TYR39 3.4 162.4 1.0
CD2 D:TYR39 3.5 162.4 1.0
N D:TYR39 3.6 162.4 1.0
CB D:CYS40 3.7 182.7 1.0
CA D:CYS40 3.8 182.7 1.0
CB D:CYS37 3.8 178.2 1.0
N D:CYS70 3.9 162.3 1.0
CA D:CYS73 4.0 146.4 1.0
CB D:CYS70 4.0 162.3 1.0
SG D:CYS40 4.1 182.7 1.0
N D:CYS73 4.4 146.4 1.0
CA D:CYS70 4.5 162.3 1.0
O D:TYR39 4.5 162.4 1.0
O D:CYS70 4.6 162.3 1.0
CD1 D:TYR39 4.8 162.4 1.0
CG2 D:VAL69 4.8 157.2 1.0
CE2 D:TYR39 4.8 162.4 1.0
CE2 D:TYR77 4.8 125.6 1.0
C D:CYS73 4.8 146.4 1.0
C D:VAL38 4.9 169.1 1.0
C D:CYS70 4.9 162.3 1.0
C D:VAL69 4.9 157.2 1.0

Zinc binding site 4 out of 4 in 8jrr

Go back to Zinc Binding Sites List in 8jrr
Zinc binding site 4 out of 4 in the Structure of E6AP-E6 Complex in DET2 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of E6AP-E6 Complex in DET2 State within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn202

b:228.3
occ:1.00
 SG D:CYS113 2.5 162.9 1.0
SG D:CYS143 2.9 192.5 1.0
SG D:CYS146 3.0 186.4 1.0
CB D:CYS113 3.2 162.9 1.0
SG D:CYS110 3.2 165.3 1.0
N D:CYS113 3.5 162.9 1.0
CB D:CYS146 3.6 186.4 1.0
CB D:ASN112 3.7 156.3 1.0
N D:CYS146 3.9 186.4 1.0
CA D:CYS113 3.9 162.9 1.0
C D:ASN112 4.1 156.3 1.0
CB D:CYS143 4.1 192.5 1.0
CB D:SER145 4.3 184.9 1.0
CB D:CYS110 4.3 165.3 1.0
CA D:ASN112 4.4 156.3 1.0
CA D:CYS146 4.4 186.4 1.0
C D:SER145 4.5 184.9 1.0
NH2 D:ARG55 4.6 156.1 1.0
N D:ASN112 4.7 156.3 1.0
N D:CYS143 4.8 192.5 1.0
CA D:SER145 4.8 184.9 1.0
CG D:ASN112 4.9 156.3 1.0
C D:CYS113 4.9 162.9 1.0
CA D:CYS143 5.0 192.5 1.0

Reference:

Z.Wang, F.Fan, Z.Li, F.Ye, Q.Wang, R.Gao, J.Qiu, Y.Lv, M.Lin, W.Xu, C.Luo, X.Yu. Structural Insights Into the Functional Mechanism of the Ubiquitin Ligase E6AP. Nat Commun V. 15 3531 2024.
ISSN: ESSN 2041-1723
PubMed: 38670961
DOI: 10.1038/S41467-024-47586-W
Page generated: Thu Oct 31 08:25:22 2024

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