Zinc in PDB 8jrq: Structure of E6AP-E6 Complex in DET1 State

Enzymatic activity of Structure of E6AP-E6 Complex in DET1 State

All present enzymatic activity of Structure of E6AP-E6 Complex in DET1 State:
2.3.2.26;

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of E6AP-E6 Complex in DET1 State (pdb code 8jrq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of E6AP-E6 Complex in DET1 State, PDB code: 8jrq:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 8jrq

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Zinc binding site 1 out of 4 in the Structure of E6AP-E6 Complex in DET1 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of E6AP-E6 Complex in DET1 State within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn201

b:156.4
occ:1.00
 N B:CYS70 2.2 109.1 1.0
SG B:CYS37 2.4 112.8 1.0
CB B:CYS70 2.5 109.1 1.0
SG B:CYS70 2.5 109.1 1.0
CA B:CYS70 2.8 109.1 1.0
C B:VAL69 3.4 107.9 1.0
CB B:CYS37 3.4 112.8 1.0
O B:CYS70 3.5 109.1 1.0
C B:CYS70 3.5 109.1 1.0
SG B:CYS40 3.6 103.0 1.0
CB B:CYS73 3.8 98.5 1.0
CA B:VAL69 4.0 107.9 1.0
SG B:CYS73 4.1 98.5 1.0
CD2 B:TYR39 4.1 93.7 1.0
CG2 B:VAL69 4.1 107.9 1.0
O B:VAL69 4.3 107.9 1.0
N B:CYS40 4.4 103.0 1.0
CB B:TYR39 4.4 93.7 1.0
CB B:CYS40 4.4 103.0 1.0
CB B:VAL69 4.6 107.9 1.0
N B:TYR39 4.7 93.7 1.0
N B:CYS73 4.7 98.5 1.0
N B:ASP71 4.7 99.0 1.0
CA B:CYS37 4.7 112.8 1.0
CG B:TYR39 4.8 93.7 1.0
CA B:CYS73 4.8 98.5 1.0
CA B:TYR39 5.0 93.7 1.0

Zinc binding site 2 out of 4 in 8jrq

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Zinc binding site 2 out of 4 in the Structure of E6AP-E6 Complex in DET1 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of E6AP-E6 Complex in DET1 State within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn202

b:180.1
occ:1.00
 SG B:CYS113 2.4 107.3 1.0
SG B:CYS110 2.4 99.7 1.0
SG B:CYS146 2.5 135.1 1.0
SG B:CYS143 2.5 129.1 1.0
CB B:CYS113 2.8 107.3 1.0
CB B:CYS143 3.1 129.1 1.0
CB B:CYS146 3.2 135.1 1.0
N B:CYS113 3.2 107.3 1.0
CB B:CYS110 3.5 99.7 1.0
CA B:CYS113 3.6 107.3 1.0
N B:CYS143 3.7 129.1 1.0
CA B:CYS143 3.9 129.1 1.0
OG B:SER145 4.0 139.8 1.0
N B:CYS146 4.1 135.1 1.0
CB B:ASN112 4.3 88.0 1.0
CA B:CYS146 4.3 135.1 1.0
C B:ASN112 4.3 88.0 1.0
C B:CYS113 4.5 107.3 1.0
C B:CYS143 4.5 129.1 1.0
CA B:ASN112 4.7 88.0 1.0
N B:GLN114 4.7 97.7 1.0
O B:CYS143 4.7 129.1 1.0
N B:ASN112 4.7 88.0 1.0
CA B:CYS110 4.9 99.7 1.0
C B:ARG142 4.9 100.7 1.0

Zinc binding site 3 out of 4 in 8jrq

Go back to Zinc Binding Sites List in 8jrq
Zinc binding site 3 out of 4 in the Structure of E6AP-E6 Complex in DET1 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of E6AP-E6 Complex in DET1 State within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn201

b:156.4
occ:1.00
 N D:CYS70 2.2 109.1 1.0
SG D:CYS37 2.4 112.8 1.0
CB D:CYS70 2.5 109.1 1.0
SG D:CYS70 2.5 109.1 1.0
CA D:CYS70 2.8 109.1 1.0
C D:VAL69 3.4 107.9 1.0
CB D:CYS37 3.4 112.8 1.0
O D:CYS70 3.5 109.1 1.0
C D:CYS70 3.5 109.1 1.0
SG D:CYS40 3.6 103.0 1.0
CB D:CYS73 3.8 98.5 1.0
CA D:VAL69 4.0 107.9 1.0
SG D:CYS73 4.1 98.5 1.0
CD2 D:TYR39 4.1 93.7 1.0
CG2 D:VAL69 4.1 107.9 1.0
O D:VAL69 4.3 107.9 1.0
N D:CYS40 4.4 103.0 1.0
CB D:TYR39 4.4 93.7 1.0
CB D:CYS40 4.4 103.0 1.0
CB D:VAL69 4.6 107.9 1.0
N D:TYR39 4.7 93.7 1.0
N D:CYS73 4.7 98.5 1.0
N D:ASP71 4.7 99.0 1.0
CA D:CYS37 4.7 112.8 1.0
CG D:TYR39 4.8 93.7 1.0
CA D:CYS73 4.8 98.5 1.0
CA D:TYR39 5.0 93.7 1.0

Zinc binding site 4 out of 4 in 8jrq

Go back to Zinc Binding Sites List in 8jrq
Zinc binding site 4 out of 4 in the Structure of E6AP-E6 Complex in DET1 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of E6AP-E6 Complex in DET1 State within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn202

b:180.1
occ:1.00
 SG D:CYS113 2.4 107.3 1.0
SG D:CYS110 2.4 99.7 1.0
SG D:CYS146 2.5 135.1 1.0
SG D:CYS143 2.5 129.1 1.0
CB D:CYS113 2.8 107.3 1.0
CB D:CYS143 3.1 129.1 1.0
CB D:CYS146 3.2 135.1 1.0
N D:CYS113 3.2 107.3 1.0
CB D:CYS110 3.5 99.7 1.0
CA D:CYS113 3.6 107.3 1.0
N D:CYS143 3.7 129.1 1.0
CA D:CYS143 3.9 129.1 1.0
OG D:SER145 4.0 139.8 1.0
N D:CYS146 4.1 135.1 1.0
CB D:ASN112 4.3 88.0 1.0
CA D:CYS146 4.3 135.1 1.0
C D:ASN112 4.3 88.0 1.0
C D:CYS113 4.5 107.3 1.0
C D:CYS143 4.5 129.1 1.0
CA D:ASN112 4.7 88.0 1.0
N D:GLN114 4.7 97.7 1.0
O D:CYS143 4.7 129.1 1.0
N D:ASN112 4.7 88.0 1.0
CA D:CYS110 4.9 99.7 1.0
C D:ARG142 4.9 100.7 1.0

Reference:

Z.Wang, F.Fan, Z.Li, F.Ye, Q.Wang, R.Gao, J.Qiu, Y.Lv, M.Lin, W.Xu, C.Luo, X.Yu. Structural Insights Into the Functional Mechanism of the Ubiquitin Ligase E6AP. Nat Commun V. 15 3531 2024.
ISSN: ESSN 2041-1723
PubMed: 38670961
DOI: 10.1038/S41467-024-47586-W
Page generated: Thu Oct 31 08:25:28 2024

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