Zinc in PDB 8jrp: Structure of E6AP-E6 Complex in ATT3 State

All present enzymatic activity of Structure of E6AP-E6 Complex in ATT3 State:
2.3.2.26;

The binding sites of Zinc atom in the Structure of E6AP-E6 Complex in ATT3 State (pdb code 8jrp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Structure of E6AP-E6 Complex in ATT3 State, PDB code: 8jrp:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Structure of E6AP-E6 Complex in ATT3 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of E6AP-E6 Complex in ATT3 State within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn201 b:113.6 occ:1.00 SG B:CYS40 2.3 85.6 1.0 SG B:CYS70 2.3 87.4 1.0 SG B:CYS73 2.3 84.8 1.0 SG B:CYS37 2.3 82.7 1.0 CB B:CYS73 3.1 84.8 1.0 CB B:CYS37 3.2 82.7 1.0 CB B:CYS40 3.3 85.6 1.0 CB B:CYS70 3.5 87.4 1.0 N B:CYS40 3.6 85.6 1.0 N B:CYS70 4.0 87.4 1.0 CA B:CYS40 4.1 85.6 1.0 N B:CYS73 4.2 84.8 1.0 CA B:CYS73 4.3 84.8 1.0 CA B:CYS70 4.3 87.4 1.0 CB B:TYR39 4.6 75.1 1.0 CA B:CYS37 4.6 82.7 1.0 C B:TYR39 4.8 75.1 1.0 N B:TYR39 4.8 75.1 1.0 C B:CYS70 4.8 87.4 1.0 O B:CYS70 4.8 87.4 1.0 C B:CYS40 4.9 85.6 1.0 NZ B:LYS72 4.9 86.3 1.0 CA B:TYR39 5.0 75.1 1.0

Zinc binding site 2 out of 4 in the Structure of E6AP-E6 Complex in ATT3 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of E6AP-E6 Complex in ATT3 State within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn202 b:113.3 occ:1.00 SG B:CYS113 2.3 77.6 1.0 SG B:CYS110 2.3 80.1 1.0 SG B:CYS146 2.3 92.9 1.0 SG B:CYS143 2.3 94.6 1.0 CB B:CYS146 3.0 92.9 1.0 CB B:CYS110 3.2 80.1 1.0 CB B:CYS143 3.2 94.6 1.0 CB B:CYS113 3.4 77.6 1.0 N B:CYS113 3.8 77.6 1.0 N B:CYS146 3.9 92.9 1.0 CA B:CYS146 4.1 92.9 1.0 CA B:CYS113 4.1 77.6 1.0 N B:CYS143 4.2 94.6 1.0 CA B:CYS143 4.2 94.6 1.0 CA B:CYS110 4.6 80.1 1.0 OD1 B:ASN112 4.7 78.3 1.0 CB B:ASN112 4.7 78.3 1.0 C B:CYS143 4.8 94.6 1.0 C B:ASN112 4.9 78.3 1.0 C B:CYS113 4.9 77.6 1.0 N B:ASN112 4.9 78.3 1.0 C B:SER145 4.9 90.8 1.0

Zinc binding site 3 out of 4 in the Structure of E6AP-E6 Complex in ATT3 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Structure of E6AP-E6 Complex in ATT3 State within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn201 b:113.6 occ:1.00 SG D:CYS40 2.3 85.6 1.0 SG D:CYS70 2.3 87.4 1.0 SG D:CYS73 2.3 84.8 1.0 SG D:CYS37 2.3 82.7 1.0 CB D:CYS73 3.1 84.8 1.0 CB D:CYS37 3.2 82.7 1.0 CB D:CYS40 3.3 85.6 1.0 CB D:CYS70 3.5 87.4 1.0 N D:CYS40 3.6 85.6 1.0 N D:CYS70 4.0 87.4 1.0 CA D:CYS40 4.1 85.6 1.0 N D:CYS73 4.2 84.8 1.0 CA D:CYS73 4.3 84.8 1.0 CA D:CYS70 4.3 87.4 1.0 CB D:TYR39 4.6 75.1 1.0 CA D:CYS37 4.6 82.7 1.0 C D:TYR39 4.8 75.1 1.0 N D:TYR39 4.8 75.1 1.0 C D:CYS70 4.8 87.4 1.0 O D:CYS70 4.8 87.4 1.0 C D:CYS40 4.9 85.6 1.0 NZ D:LYS72 4.9 86.3 1.0 CA D:TYR39 5.0 75.1 1.0

Zinc binding site 4 out of 4 in the Structure of E6AP-E6 Complex in ATT3 State


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Structure of E6AP-E6 Complex in ATT3 State within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn202 b:113.3 occ:1.00 SG D:CYS113 2.3 77.6 1.0 SG D:CYS110 2.3 80.1 1.0 SG D:CYS146 2.3 92.9 1.0 SG D:CYS143 2.3 94.6 1.0 CB D:CYS146 3.0 92.9 1.0 CB D:CYS110 3.2 80.1 1.0 CB D:CYS143 3.2 94.6 1.0 CB D:CYS113 3.4 77.6 1.0 N D:CYS113 3.8 77.6 1.0 N D:CYS146 3.9 92.9 1.0 CA D:CYS146 4.1 92.9 1.0 CA D:CYS113 4.1 77.6 1.0 N D:CYS143 4.2 94.6 1.0 CA D:CYS143 4.2 94.6 1.0 CA D:CYS110 4.6 80.1 1.0 OD1 D:ASN112 4.7 78.3 1.0 CB D:ASN112 4.7 78.3 1.0 C D:CYS143 4.8 94.6 1.0 C D:ASN112 4.9 78.3 1.0 C D:CYS113 4.9 77.6 1.0 N D:ASN112 4.9 78.3 1.0 C D:SER145 4.9 90.8 1.0

Z.Wang, F.Fan, Z.Li, F.Ye, Q.Wang, R.Gao, J.Qiu, Y.Lv, M.Lin, W.Xu, C.Luo, X.Yu. Structural Insights Into the Functional Mechanism of the Ubiquitin Ligase E6AP. Nat Commun V. 15 3531 2024.
ISSN: ESSN 2041-1723
PubMed: 38670961
DOI: 10.1038/S41467-024-47586-W