Zinc in PDB 8ii0: Factor Inhibiting Hif-1 Alpha in Complex with (5-(3-(3-Chlorophenyl) Isoxazol-5-Yl)-3-Hydroxypicolinoyl)Glycine

Enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with (5-(3-(3-Chlorophenyl) Isoxazol-5-Yl)-3-Hydroxypicolinoyl)Glycine

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with (5-(3-(3-Chlorophenyl) Isoxazol-5-Yl)-3-Hydroxypicolinoyl)Glycine:
1.14.11.30;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha in Complex with (5-(3-(3-Chlorophenyl) Isoxazol-5-Yl)-3-Hydroxypicolinoyl)Glycine, PDB code: 8ii0 was solved by Y.Nakashima, T.Corner, X.Zhang, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.31 / 2.04
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.615, 86.615, 147.097, 90, 90, 90
R / Rfree (%) 20.5 / 23.9

Other elements in 8ii0:

The structure of Factor Inhibiting Hif-1 Alpha in Complex with (5-(3-(3-Chlorophenyl) Isoxazol-5-Yl)-3-Hydroxypicolinoyl)Glycine also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with (5-(3-(3-Chlorophenyl) Isoxazol-5-Yl)-3-Hydroxypicolinoyl)Glycine (pdb code 8ii0). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with (5-(3-(3-Chlorophenyl) Isoxazol-5-Yl)-3-Hydroxypicolinoyl)Glycine, PDB code: 8ii0:

Zinc binding site 1 out of 1 in 8ii0

Go back to Zinc Binding Sites List in 8ii0
Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with (5-(3-(3-Chlorophenyl) Isoxazol-5-Yl)-3-Hydroxypicolinoyl)Glycine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with (5-(3-(3-Chlorophenyl) Isoxazol-5-Yl)-3-Hydroxypicolinoyl)Glycine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1004

b:60.5
occ:1.00
 OD2 A:ASP201 2.0 57.6 1.0
NE2 A:HIS199 2.1 68.9 1.0
NE2 A:HIS279 2.1 68.9 1.0
O A:HOH1102 2.3 104.2 1.0
N09 A:P5I1001 2.4 155.1 1.0
O01 A:P5I1001 2.5 111.6 1.0
CE1 A:HIS199 3.0 63.3 1.0
C08 A:P5I1001 3.0 147.3 1.0
CD2 A:HIS279 3.0 64.3 1.0
CG A:ASP201 3.1 50.3 1.0
CD2 A:HIS199 3.1 56.6 1.0
C02 A:P5I1001 3.1 127.7 1.0
CE1 A:HIS279 3.2 66.4 1.0
C10 A:P5I1001 3.2 158.9 1.0
OD1 A:ASP201 3.4 57.8 1.0
O A:HOH1135 3.8 78.3 1.0
ND1 A:HIS199 4.1 60.7 1.0
CG A:HIS199 4.2 59.8 1.0
C25 A:P5I1001 4.2 154.2 1.0
CG A:HIS279 4.2 64.2 1.0
ND1 A:HIS279 4.3 63.3 1.0
C11 A:P5I1001 4.4 161.6 1.0
CB A:ASP201 4.4 46.1 1.0
CZ2 A:TRP296 4.5 96.6 1.0
N03 A:P5I1001 4.5 124.1 1.0
C24 A:P5I1001 4.8 157.8 1.0

Reference:

Y.Nakashima, T.Corner, X.Zhang, C.J.Schofield. A Small-Molecule Fih Inhibitor Binding to A Tyrosine-Flip Pocket Ameliorates Obesity and Mafld To Be Published.
Page generated: Thu Oct 31 07:47:29 2024

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