Zinc in PDB 8igf: Crystal Structure of Human Carbonic Anhydrase II in-Complex with 4- Acetylphenylboronic Acid at 2.6 A Resolution

Enzymatic activity of Crystal Structure of Human Carbonic Anhydrase II in-Complex with 4- Acetylphenylboronic Acid at 2.6 A Resolution

All present enzymatic activity of Crystal Structure of Human Carbonic Anhydrase II in-Complex with 4- Acetylphenylboronic Acid at 2.6 A Resolution:
4.2.1.1; 4.2.1.69;

Protein crystallography data

The structure of Crystal Structure of Human Carbonic Anhydrase II in-Complex with 4- Acetylphenylboronic Acid at 2.6 A Resolution, PDB code: 8igf was solved by S.Rasheed, N.Huda, S.Z.Fisher, S.Falke, S.Gul, M.S.Ahmad, M.I.Choudhary, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.54 / 2.60
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.068, 41.029, 71.628, 90, 104.19, 90
R / Rfree (%) 19.7 / 25.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Human Carbonic Anhydrase II in-Complex with 4- Acetylphenylboronic Acid at 2.6 A Resolution (pdb code 8igf). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human Carbonic Anhydrase II in-Complex with 4- Acetylphenylboronic Acid at 2.6 A Resolution, PDB code: 8igf:

Zinc binding site 1 out of 1 in 8igf

Go back to Zinc Binding Sites List in 8igf
Zinc binding site 1 out of 1 in the Crystal Structure of Human Carbonic Anhydrase II in-Complex with 4- Acetylphenylboronic Acid at 2.6 A Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human Carbonic Anhydrase II in-Complex with 4- Acetylphenylboronic Acid at 2.6 A Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn301

b:8.5
occ:1.00
 NE2 A:HIS94 1.8 9.1 1.0
ND1 A:HIS119 2.2 7.9 1.0
NE2 A:HIS96 2.3 7.3 1.0
H6 A:OY7501 2.5 20.0 1.0
CE1 A:HIS94 2.7 8.9 1.0
CE1 A:HIS96 2.9 7.9 1.0
CD2 A:HIS94 2.9 9.3 1.0
B1 A:OY7501 3.0 20.0 1.0
CE1 A:HIS119 3.0 7.5 1.0
O1 A:OY7501 3.0 20.0 1.0
CG A:HIS119 3.3 8.6 1.0
OG1 A:THR199 3.3 8.8 1.0
O2 A:OY7501 3.4 20.0 1.0
H7 A:OY7501 3.4 20.0 1.0
C1 A:OY7501 3.5 20.0 1.0
CD2 A:HIS96 3.6 8.1 1.0
CB A:HIS119 3.8 8.5 1.0
ND1 A:HIS94 3.8 9.9 1.0
CG A:HIS94 4.0 9.3 1.0
H5 A:OY7501 4.0 20.0 1.0
O1 A:GOL302 4.1 9.4 1.0
OE1 A:GLU106 4.1 8.5 1.0
C8 A:OY7501 4.1 20.0 1.0
NE2 A:HIS119 4.1 7.5 1.0
ND1 A:HIS96 4.2 8.0 1.0
CD2 A:HIS119 4.3 8.4 1.0
C2 A:OY7501 4.4 20.0 1.0
H8 A:OY7501 4.5 20.0 1.0
CG A:HIS96 4.5 8.2 1.0
CB A:THR199 4.6 8.4 1.0
CG2 A:THR199 4.9 7.7 1.0
CD A:GLU106 4.9 8.1 1.0

Reference:

S.Rasheed, N.Huda, S.Z.Fisher, S.Falke, S.Gul, M.S.Ahmad, M.I.Choudhary. Crystal Structure of Human Carbonic Anhydrase II in-Complex with 4-Acetylphenylboronic Acid at 2.6 A Resolution To Be Published.
Page generated: Thu Oct 31 07:44:35 2024

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