Zinc in PDB 8i91: ACE2-SIT1 Complex Bound with Proline

All present enzymatic activity of ACE2-SIT1 Complex Bound with Proline:
3.4.17.23;

The structure of ACE2-SIT1 Complex Bound with Proline also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Zinc atom in the ACE2-SIT1 Complex Bound with Proline (pdb code 8i91). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the ACE2-SIT1 Complex Bound with Proline, PDB code: 8i91:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the ACE2-SIT1 Complex Bound with Proline


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of ACE2-SIT1 Complex Bound with Proline within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn902 b:118.0 occ:1.00 OE2 A:GLU402 1.8 92.0 1.0 NE2 A:HIS374 2.0 95.3 1.0 NE2 A:HIS378 2.1 91.8 1.0 CD A:GLU402 2.6 92.0 1.0 CD2 A:HIS374 2.7 95.3 1.0 OE1 A:GLU402 2.7 92.0 1.0 CE1 A:HIS378 3.0 91.8 1.0 CD2 A:HIS378 3.1 91.8 1.0 CE1 A:HIS374 3.2 95.3 1.0 CG A:HIS374 3.9 95.3 1.0 CG A:GLU402 4.1 92.0 1.0 ND1 A:HIS378 4.1 91.8 1.0 OE2 A:GLU375 4.1 100.2 1.0 ND1 A:HIS374 4.1 95.3 1.0 CG A:HIS378 4.2 91.8 1.0 OE1 A:GLU375 4.4 100.2 1.0 CD A:GLU375 4.5 100.2 1.0

Zinc binding site 2 out of 2 in the ACE2-SIT1 Complex Bound with Proline


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of ACE2-SIT1 Complex Bound with Proline within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn902 b:118.0 occ:1.00 OE2 C:GLU402 1.8 92.0 1.0 NE2 C:HIS374 2.0 95.3 1.0 NE2 C:HIS378 2.1 91.8 1.0 CD C:GLU402 2.6 92.0 1.0 CD2 C:HIS374 2.7 95.3 1.0 OE1 C:GLU402 2.7 92.0 1.0 CE1 C:HIS378 3.0 91.8 1.0 CD2 C:HIS378 3.1 91.8 1.0 CE1 C:HIS374 3.2 95.3 1.0 CG C:HIS374 3.9 95.3 1.0 CG C:GLU402 4.1 92.0 1.0 ND1 C:HIS378 4.1 91.8 1.0 OE2 C:GLU375 4.1 100.2 1.0 ND1 C:HIS374 4.1 95.3 1.0 CG C:HIS378 4.2 91.8 1.0 OE1 C:GLU375 4.4 100.2 1.0 CD C:GLU375 4.5 100.2 1.0

Y.Li, Y.Chen, Y.Zhang, Y.Shen, K.Xu, Y.Liu, Z.Wang, R.Yan. Structural Insight Into the Substrate Recognition and Transport Mechanism of Amino Acid Transporter Complex ACE2-B 0 AT1 and ACE2-SIT1. Cell Discov V. 9 93 2023.
ISSN: ESSN 2056-5968
PubMed: 37684251
DOI: 10.1038/S41421-023-00596-2