Zinc in PDB 8hk6: Potassium Channel

The structure of Potassium Channel also contains other interesting chemical elements:

Potassium

(K)

20 atoms

The binding sites of Zinc atom in the Potassium Channel (pdb code 8hk6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Potassium Channel, PDB code: 8hk6:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Potassium Channel


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Potassium Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1303 b:152.2 occ:1.00 ND1 A:HIS787 2.1 113.9 1.0 SG A:CYS777 2.3 74.7 1.0 SG A:CYS778 2.3 82.7 1.0 SG A:CYS785 2.3 105.5 1.0 CE1 A:HIS787 2.8 111.3 1.0 CG A:HIS787 3.1 112.0 1.0 CB A:CYS785 3.2 105.0 1.0 N A:CYS778 3.5 67.8 1.0 CB A:CYS778 3.6 70.4 1.0 CB A:CYS777 3.7 72.9 1.0 CB A:HIS787 3.7 111.5 1.0 CA A:CYS778 3.8 66.8 1.0 C A:CYS777 3.8 72.7 1.0 NE2 A:HIS787 3.9 111.1 1.0 N A:HIS787 4.0 112.3 1.0 CD2 A:HIS787 4.1 111.1 1.0 CA A:CYS777 4.3 71.7 1.0 O A:CYS777 4.3 76.4 1.0 CG A:PRO775 4.4 70.7 1.0 N A:LYS786 4.4 112.6 1.0 CA A:HIS787 4.4 112.1 1.0 CA A:CYS785 4.6 106.8 1.0 C A:CYS785 4.8 107.5 1.0 CB A:PRO775 4.9 70.5 1.0 N A:ASN788 4.9 107.8 1.0 N A:CYS777 5.0 74.4 1.0 ND2 A:ASN788 5.0 107.1 1.0 OD1 A:ASN788 5.0 107.8 1.0

Zinc binding site 2 out of 4 in the Potassium Channel


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Potassium Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1303 b:178.1 occ:1.00 ND1 B:HIS787 2.1 114.0 1.0 SG B:CYS777 2.3 75.1 1.0 SG B:CYS778 2.3 82.6 1.0 SG B:CYS785 2.3 105.3 1.0 CG B:HIS787 3.1 112.3 1.0 CE1 B:HIS787 3.1 112.1 1.0 CB B:CYS785 3.3 103.3 1.0 CB B:HIS787 3.4 111.6 1.0 N B:HIS787 3.7 112.8 1.0 CB B:CYS777 3.8 73.8 1.0 CB B:CYS778 3.8 71.8 1.0 N B:CYS778 3.9 70.0 1.0 CA B:CYS778 4.1 69.5 1.0 CA B:HIS787 4.1 112.7 1.0 NE2 B:HIS787 4.1 112.2 1.0 CD2 B:HIS787 4.2 112.5 1.0 C B:CYS777 4.2 74.0 1.0 N B:LYS786 4.3 111.0 1.0 OD1 B:ASN788 4.4 107.3 1.0 CG B:PRO775 4.4 69.1 1.0 CA B:CYS785 4.6 105.1 1.0 CA B:CYS777 4.6 72.7 1.0 C B:CYS785 4.7 106.1 1.0 O B:CYS777 4.7 79.0 1.0 C B:LYS786 4.8 110.8 1.0 N B:ASN788 4.8 107.4 1.0 CB B:PRO775 4.9 67.1 1.0 CA B:LYS786 5.0 111.0 1.0 C B:HIS787 5.0 112.7 1.0

Zinc binding site 3 out of 4 in the Potassium Channel


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Potassium Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1303 b:159.3 occ:1.00 ND1 C:HIS787 2.1 113.9 1.0 SG C:CYS777 2.3 73.2 1.0 SG C:CYS785 2.3 106.7 1.0 SG C:CYS778 2.3 82.6 1.0 CE1 C:HIS787 2.8 111.6 1.0 CG C:HIS787 3.1 111.4 1.0 CB C:CYS785 3.2 104.3 1.0 N C:CYS778 3.5 68.4 1.0 CB C:CYS777 3.7 71.4 1.0 CB C:CYS778 3.7 70.7 1.0 CB C:HIS787 3.7 111.3 1.0 CA C:CYS778 3.8 67.6 1.0 C C:CYS777 3.8 72.7 1.0 NE2 C:HIS787 3.9 111.2 1.0 N C:HIS787 4.0 112.2 1.0 CD2 C:HIS787 4.1 111.0 1.0 CA C:CYS777 4.3 71.4 1.0 O C:CYS777 4.4 77.3 1.0 CG C:PRO775 4.4 67.3 1.0 CA C:HIS787 4.4 112.4 1.0 N C:LYS786 4.4 115.8 1.0 CA C:CYS785 4.5 106.2 1.0 C C:CYS785 4.8 106.8 1.0 CB C:PRO775 4.9 67.0 1.0 N C:CYS777 4.9 73.4 1.0 N C:ASN788 5.0 107.5 1.0 ND2 C:ASN788 5.0 107.3 1.0

Zinc binding site 4 out of 4 in the Potassium Channel


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Potassium Channel within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1303 b:162.2 occ:1.00 ND1 D:HIS787 2.1 111.6 1.0 SG D:CYS777 2.3 77.6 1.0 SG D:CYS785 2.3 106.5 1.0 SG D:CYS778 2.3 83.0 1.0 CE1 D:HIS787 2.7 109.2 1.0 CG D:HIS787 3.2 109.0 1.0 CB D:CYS785 3.3 104.9 1.0 N D:CYS778 3.5 69.8 1.0 CB D:CYS778 3.7 71.0 1.0 CB D:CYS777 3.7 74.3 1.0 CB D:HIS787 3.7 108.5 1.0 CA D:CYS778 3.8 68.0 1.0 C D:CYS777 3.9 74.1 1.0 NE2 D:HIS787 3.9 108.9 1.0 N D:HIS787 4.0 109.9 1.0 CD2 D:HIS787 4.1 108.7 1.0 CA D:CYS777 4.3 72.4 1.0 O D:CYS777 4.4 78.6 1.0 CG D:PRO775 4.4 68.1 1.0 CE D:LYS786 4.4 111.3 1.0 N D:LYS786 4.5 110.1 1.0 CA D:HIS787 4.5 110.0 1.0 NZ D:LYS786 4.6 110.4 1.0 CA D:CYS785 4.6 106.5 1.0 OD1 D:ASN788 4.6 107.5 1.0 C D:CYS785 4.8 106.3 1.0 CB D:PRO775 4.9 68.4 1.0 N D:CYS777 4.9 75.2 1.0 N D:ASN788 5.0 106.7 1.0

J.Zhang, S.Liu, J.Fan, R.Yan, B.Huang, F.Zhou, T.Yuan, J.Gong, Z.Huang, D.Jiang. Structural Basis of Human SLO2.2 Channel Gating and Modulation. Cell Rep V. 42 12858 2023.
ISSN: ESSN 2211-1247
PubMed: 37494189
DOI: 10.1016/J.CELREP.2023.112858