Zinc in PDB 8hgz: Crystal Structure of Insulin

The structure of Crystal Structure of Insulin, PDB code: 8hgz was solved by H.Demirci, E.Ayan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	21.64 / 1.70
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	78.885, 78.885, 79.272, 90, 90, 120
R / Rfree (%)	21.8 / 25.8

The structure of Crystal Structure of Insulin also contains other interesting chemical elements:

Chlorine

(Cl)

4 atoms

The binding sites of Zinc atom in the Crystal Structure of Insulin (pdb code 8hgz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Insulin, PDB code: 8hgz:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Crystal Structure of Insulin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Insulin within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn102 b:17.8 occ:0.34 CL F:CL103 2.3 14.2 0.3 NE2 F:HIS10 2.3 15.0 1.0 CE1 F:HIS10 3.2 22.7 1.0 CD2 F:HIS10 3.3 20.6 1.0 ND1 F:HIS10 4.4 15.2 1.0 CG F:HIS10 4.4 14.1 1.0 O F:LEU6 4.7 14.0 1.0 O F:HOH204 4.8 31.4 1.0 CB F:LEU6 4.9 14.8 1.0

Zinc binding site 2 out of 4 in the Crystal Structure of Insulin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Insulin within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn101 b:13.4 occ:0.33 CL B:CL102 2.3 15.4 0.3 NE2 B:HIS10 2.3 10.9 1.0 CD2 B:HIS10 3.2 14.2 1.0 CE1 B:HIS10 3.3 21.1 1.0 CG B:HIS10 4.4 10.3 1.0 ND1 B:HIS10 4.4 16.7 1.0 O B:LEU6 4.8 15.3 1.0 CB B:LEU6 4.8 12.6 1.0 O B:HOH220 5.0 28.8 1.0

Zinc binding site 3 out of 4 in the Crystal Structure of Insulin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Insulin within 5.0Å range: probe atom residue distance (Å) B Occ J:Zn102 b:14.8 occ:0.29 CL J:CL103 2.2 18.7 0.4 NE2 J:HIS10 2.3 11.5 1.0 CD2 J:HIS10 3.2 9.9 1.0 CE1 J:HIS10 3.3 18.7 1.0 O J:HOH229 4.2 32.5 0.3 CG J:HIS10 4.4 11.7 1.0 ND1 J:HIS10 4.4 18.0 1.0 O J:HOH225 4.6 32.2 1.0 O J:LEU6 4.8 14.3 1.0 CB J:LEU6 4.9 11.8 1.0

Zinc binding site 4 out of 4 in the Crystal Structure of Insulin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Insulin within 5.0Å range: probe atom residue distance (Å) B Occ N:Zn101 b:14.7 occ:0.31 CL N:CL102 2.2 13.4 0.3 NE2 N:HIS10 2.3 17.4 1.0 CD2 N:HIS10 3.2 18.5 1.0 CE1 N:HIS10 3.3 18.4 1.0 O N:HOH216 4.1 32.1 0.3 ND1 N:HIS10 4.4 18.1 1.0 CG N:HIS10 4.4 12.9 1.0 O N:LEU6 4.8 14.5 1.0 CB N:LEU6 4.9 13.8 1.0

E.Ayan, E.Destan, A.Kepceoglu, H.I.Ciftci, A.Kati, H.Demirci. Comparative Study of High-Resolution LYSB29(N Epsilon-Myristoyl) Des(B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions Crystals V. 13 2023.
ISSN: ESSN 2073-4352
DOI: 10.3390/CRYST13040648