Zinc in PDB 8hgh: Structure of 2:2 Papp-A.STC2 Complex

All present enzymatic activity of Structure of 2:2 Papp-A.STC2 Complex:
3.4.24.79;

The binding sites of Zinc atom in the Structure of 2:2 Papp-A.STC2 Complex (pdb code 8hgh). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of 2:2 Papp-A.STC2 Complex, PDB code: 8hgh:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of 2:2 Papp-A.STC2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of 2:2 Papp-A.STC2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1601 b:98.1 occ:1.00 CE1 A:HIS492 1.8 73.9 1.0 CE1 A:HIS482 2.1 65.8 1.0 NE2 A:HIS486 2.3 52.7 1.0 NE2 A:HIS482 2.3 65.8 1.0 NE2 A:HIS492 2.3 73.9 1.0 ND1 A:HIS492 3.0 73.9 1.0 CD2 A:HIS486 3.2 52.7 1.0 CE1 A:HIS486 3.2 52.7 1.0 ND1 A:HIS482 3.4 65.8 1.0 CD1 A:LEU445 3.4 116.4 1.0 CD2 A:HIS492 3.6 73.9 1.0 CD2 A:HIS482 3.7 65.8 1.0 CG A:HIS492 3.9 73.9 1.0 OH A:TYR558 3.9 103.1 1.0 CE1 A:TYR558 4.0 103.1 1.0 CG A:HIS482 4.2 65.8 1.0 ND1 A:HIS486 4.2 52.7 1.0 CG A:HIS486 4.2 52.7 1.0 CZ A:TYR558 4.4 103.1 1.0 CG A:LEU445 4.7 116.4 1.0 CD2 A:LEU445 4.9 116.4 1.0 OE2 A:GLU483 5.0 69.2 1.0

Zinc binding site 2 out of 2 in the Structure of 2:2 Papp-A.STC2 Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of 2:2 Papp-A.STC2 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1601 b:67.0 occ:1.00 CE1 B:HIS492 1.8 63.7 1.0 CE1 B:HIS482 2.2 58.2 1.0 NE2 B:HIS482 2.3 58.2 1.0 NE2 B:HIS486 2.3 42.8 1.0 NE2 B:HIS492 2.3 63.7 1.0 ND1 B:HIS492 3.0 63.7 1.0 CE1 B:HIS486 3.2 42.8 1.0 CD1 B:LEU445 3.2 99.6 1.0 CD2 B:HIS486 3.3 42.8 1.0 ND1 B:HIS482 3.5 58.2 1.0 CD2 B:HIS492 3.6 63.7 1.0 OH B:TYR558 3.6 86.4 1.0 CD2 B:HIS482 3.7 58.2 1.0 CE1 B:TYR558 3.7 86.4 1.0 CG B:HIS492 3.9 63.7 1.0 CZ B:TYR558 4.1 86.4 1.0 CG B:HIS482 4.2 58.2 1.0 ND1 B:HIS486 4.3 42.8 1.0 CG B:LEU445 4.4 99.6 1.0 CG B:HIS486 4.4 42.8 1.0 CD2 B:LEU445 4.6 99.6 1.0 CD1 B:TYR558 4.8 86.4 1.0

Q.Zhong, H.Chu, G.Wang, C.Zhang, R.Li, F.Guo, X.Meng, X.Lei, Y.Zhou, R.Ren, L.Tao, N.Li, N.Gao, Y.Wei, J.Qiao, J.Hang. Structural Insights Into the Covalent Regulation of Papp-A Activity By Prombp and STC2. Cell Discov V. 8 137 2022.
ISSN: ESSN 2056-5968
PubMed: 36550107
DOI: 10.1038/S41421-022-00502-2