Zinc in PDB 8hgg: Structure of 2:2 Papp-A.Prombp Complex

The binding sites of Zinc atom in the Structure of 2:2 Papp-A.Prombp Complex (pdb code 8hgg). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of 2:2 Papp-A.Prombp Complex, PDB code: 8hgg:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of 2:2 Papp-A.Prombp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of 2:2 Papp-A.Prombp Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn1601 b:6.6 occ:1.00 CE1 C:HIS492 1.4 3.4 1.0 NE2 C:HIS492 2.3 3.4 1.0 NE2 C:HIS482 2.3 5.4 1.0 NE2 C:HIS486 2.3 2.9 1.0 ND1 C:HIS492 2.5 3.4 1.0 CE1 C:HIS482 3.1 5.4 1.0 CD2 C:HIS486 3.3 2.9 1.0 CE1 C:HIS486 3.3 2.9 1.0 CD2 C:HIS482 3.4 5.4 1.0 CD2 C:HIS492 3.5 3.4 1.0 CG C:HIS492 3.5 3.4 1.0 ND1 C:HIS482 4.3 5.4 1.0 ND1 C:HIS486 4.4 2.9 1.0 CG C:HIS486 4.4 2.9 1.0 CD1 C:LEU445 4.4 13.7 1.0 CG C:HIS482 4.5 5.4 1.0 CE1 C:TYR558 4.7 8.0 1.0 CD2 C:LEU445 4.7 13.7 1.0 OE2 C:GLU483 4.8 5.7 1.0 O C:MET556 4.9 3.8 1.0 CB C:HIS492 4.9 3.4 1.0

Zinc binding site 2 out of 2 in the Structure of 2:2 Papp-A.Prombp Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of 2:2 Papp-A.Prombp Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn1601 b:9.8 occ:1.00 CE1 D:HIS492 1.4 3.9 1.0 NE2 D:HIS492 2.3 3.9 1.0 NE2 D:HIS482 2.3 5.7 1.0 NE2 D:HIS486 2.3 5.0 1.0 ND1 D:HIS492 2.5 3.9 1.0 CE1 D:HIS482 3.1 5.7 1.0 CD2 D:HIS486 3.2 5.0 1.0 CE1 D:HIS486 3.3 5.0 1.0 CD2 D:HIS482 3.4 5.7 1.0 CD2 D:HIS492 3.5 3.9 1.0 CG D:HIS492 3.6 3.9 1.0 ND1 D:HIS482 4.3 5.7 1.0 ND1 D:HIS486 4.4 5.0 1.0 CG D:HIS486 4.4 5.0 1.0 CG D:HIS482 4.5 5.7 1.0 CD1 D:LEU445 4.5 13.1 1.0 CD2 D:LEU445 4.7 13.1 1.0 CE1 D:TYR558 4.7 8.1 1.0 OE2 D:GLU483 4.8 5.8 1.0 O D:MET556 5.0 4.4 1.0 CB D:HIS492 5.0 3.9 1.0

Q.Zhong, H.Chu, G.Wang, C.Zhang, R.Li, F.Guo, X.Meng, X.Lei, Y.Zhou, R.Ren, L.Tao, N.Li, N.Gao, Y.Wei, J.Qiao, J.Hang. Structural Insights Into the Covalent Regulation of Papp-A Activity By Prombp and STC2. Cell Discov V. 8 137 2022.
ISSN: ESSN 2056-5968
PubMed: 36550107
DOI: 10.1038/S41421-022-00502-2