Zinc in PDB 8gzq: Cryo-Em Structure of the NS5-NS3-Sla Complex

The binding sites of Zinc atom in the Cryo-Em Structure of the NS5-NS3-Sla Complex (pdb code 8gzq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Cryo-Em Structure of the NS5-NS3-Sla Complex, PDB code: 8gzq:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Cryo-Em Structure of the NS5-NS3-Sla Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Cryo-Em Structure of the NS5-NS3-Sla Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1001 b:147.5 occ:1.00 NE2 A:HIS714 2.0 99.8 1.0 NE2 A:HIS712 2.0 95.1 1.0 SG A:CYS847 2.3 112.0 1.0 SG A:CYS728 2.3 92.9 1.0 CE1 A:HIS712 2.8 95.1 1.0 CE1 A:HIS714 2.9 99.8 1.0 CD2 A:HIS714 3.0 99.8 1.0 CD2 A:HIS712 3.0 95.1 1.0 CB A:CYS728 3.2 92.9 1.0 CB A:CYS847 3.4 112.0 1.0 ND1 A:HIS712 3.9 95.1 1.0 ND1 A:HIS714 4.0 99.8 1.0 CG A:HIS712 4.0 95.1 1.0 CG A:HIS714 4.1 99.8 1.0 CA A:CYS728 4.5 92.9 1.0 C A:CYS728 4.5 92.9 1.0 NH1 A:ARG769 4.6 94.3 1.0 O A:CYS728 4.6 92.9 1.0 CA A:CYS847 4.8 112.0 1.0 N A:ARG729 5.0 91.0 1.0

Zinc binding site 2 out of 2 in the Cryo-Em Structure of the NS5-NS3-Sla Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Cryo-Em Structure of the NS5-NS3-Sla Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1002 b:164.7 occ:1.00 OE2 A:GLU437 1.9 138.4 1.0 SG A:CYS446 2.3 135.0 1.0 NE2 A:HIS441 2.3 134.1 1.0 SG A:CYS449 2.3 131.5 1.0 CB A:CYS446 2.8 135.0 1.0 CB A:CYS449 3.0 131.5 1.0 CA A:CYS446 3.1 135.0 1.0 CD A:GLU437 3.1 138.4 1.0 CD2 A:HIS441 3.1 134.1 1.0 N A:GLY447 3.3 128.4 1.0 CE1 A:HIS441 3.3 134.1 1.0 C A:CYS446 3.5 135.0 1.0 N A:CYS449 3.6 131.5 1.0 CA A:CYS449 3.9 131.5 1.0 CG A:GLU437 3.9 138.4 1.0 OE1 A:GLU437 4.0 138.4 1.0 N A:SER448 4.1 132.2 1.0 CG A:HIS441 4.3 134.1 1.0 ND1 A:HIS441 4.4 134.1 1.0 N A:CYS446 4.4 135.0 1.0 CA A:GLY447 4.5 128.4 1.0 O A:CYS446 4.6 135.0 1.0 C A:SER448 4.6 132.2 1.0 O A:LYS445 4.7 127.2 1.0 C A:GLY447 4.8 128.4 1.0 CA A:SER448 5.0 132.2 1.0

T.Osawa, M.Aoki, H.Ehara, S.I.Sekine. Structures of Dengue Virus Rna Replicase Complexes. Mol.Cell 2023.
ISSN: ISSN 1097-2765
PubMed: 37478848
DOI: 10.1016/J.MOLCEL.2023.06.023