Zinc in PDB 8gm5: Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop

Enzymatic activity of Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop

All present enzymatic activity of Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop:
2.7.11.20;

Protein crystallography data

The structure of Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop, PDB code: 8gm5 was solved by A.Piserchio, E.A.Isiorho, K.N.Dalby, R.Ghose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.94 / 2.12
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 80.909, 61.041, 88.958, 90, 111.26, 90
R / Rfree (%) 18.1 / 22.5

Other elements in 8gm5:

The structure of Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop also contains other interesting chemical elements:

Calcium (Ca) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop (pdb code 8gm5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop, PDB code: 8gm5:

Zinc binding site 1 out of 1 in 8gm5

Go back to Zinc Binding Sites List in 8gm5
Zinc binding site 1 out of 1 in the Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Functional Construct of the Eukaryotic Elongation Factor 2 Kinase Bound to Calmodulin, Adp and to the A-484954 Inhibitor and Showing Two Conformations For the 498-520 Loop within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn803

b:35.9
occ:1.00
 NE2 A:HIS312 2.0 21.4 1.0
ND1 A:HIS260 2.1 32.9 1.0
SG A:CYS318 2.3 34.2 1.0
SG A:CYS314 2.3 37.5 1.0
CE1 A:HIS260 3.0 39.5 1.0
CD2 A:HIS312 3.0 31.5 1.0
CE1 A:HIS312 3.1 24.6 1.0
CG A:HIS260 3.1 40.0 1.0
CB A:CYS318 3.1 44.2 1.0
CB A:CYS314 3.4 24.4 1.0
CA A:CYS314 3.4 32.3 1.0
CB A:HIS260 3.5 32.6 1.0
NE2 A:HIS260 4.1 42.5 1.0
ND1 A:HIS312 4.1 27.5 1.0
CG A:HIS312 4.2 23.7 1.0
N A:CYS314 4.2 32.2 1.0
CD2 A:HIS260 4.2 29.2 1.0
O A:HOH940 4.5 48.0 1.0
CA A:CYS318 4.5 38.9 1.0
C A:CYS314 4.5 42.6 1.0
N A:ASN315 4.6 39.5 1.0
CD1 A:LEU323 4.7 33.8 1.0
C A:ALA313 4.9 38.8 1.0
O A:ALA313 4.9 48.6 1.0
CB A:LEU323 5.0 48.8 1.0

Reference:

A.Piserchio, E.A.Isiorho, K.N.Dalby, R.Ghose. Structure of the Complex Between Calmodulin and A Functional Construct of Eukaryotic Elongation Factor 2 Kinase Bound to An Atp-Competitive Inhibitor. J.Biol.Chem. 04813 2023.
ISSN: ESSN 1083-351X
PubMed: 37172726
DOI: 10.1016/J.JBC.2023.104813
Page generated: Fri Jul 28 06:58:34 2023

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