Zinc in PDB 8g41: Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh

All present enzymatic activity of Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh:
1.1.1.1;

The structure of Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh, PDB code: 8g41 was solved by B.V.Plapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.91 / 1.50
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	44.06, 51.32, 92.75, 91.9, 103.08, 109.89
R / Rfree (%)	15.5 / 17.7

The binding sites of Zinc atom in the Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh (pdb code 8g41). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh, PDB code: 8g41:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:12.4 occ:1.00 NE2 A:HIS67 2.1 8.7 1.0 O A:HOH548 2.1 13.0 1.0 SG A:CYS174 2.2 11.7 1.0 SG A:CYS46 2.3 12.3 1.0 CD2 A:HIS67 3.0 8.6 1.0 CE1 A:HIS67 3.1 9.8 1.0 CB A:CYS46 3.2 12.3 1.0 CB A:CYS174 3.3 9.5 1.0 C5N A:NAI403 3.4 9.2 1.0 O A:HOH774 3.9 21.3 1.0 C4N A:NAI403 4.0 9.1 1.0 C6N A:NAI403 4.0 8.6 1.0 OG A:SER48 4.0 10.2 1.0 CB A:SER48 4.2 9.3 1.0 CG A:HIS67 4.2 10.0 1.0 ND1 A:HIS67 4.2 9.9 1.0 NH2 A:ARG369 4.4 13.2 1.0 CA A:CYS174 4.7 9.1 1.0 OE2 A:GLU68 4.7 13.0 1.0 CA A:CYS46 4.7 13.1 1.0 CE2 A:PHE93 4.8 9.8 1.0 C A:CYS174 5.0 9.8 1.0

Zinc binding site 2 out of 4 in the Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn402 b:10.9 occ:1.00 SG A:CYS100 2.3 11.5 1.0 SG A:CYS97 2.3 12.8 1.0 SG A:CYS111 2.3 10.0 1.0 SG A:CYS103 2.4 10.6 1.0 CB A:CYS111 3.4 10.1 1.0 CB A:CYS100 3.4 12.2 1.0 CB A:CYS103 3.4 10.4 1.0 CB A:CYS97 3.4 10.2 1.0 N A:CYS97 3.6 9.5 1.0 CA A:CYS111 3.8 10.0 1.0 N A:CYS100 3.9 13.7 1.0 CA A:CYS97 3.9 11.0 1.0 N A:LEU112 4.0 11.6 1.0 N A:GLY98 4.0 13.2 1.0 CA A:CYS100 4.2 14.1 1.0 N A:CYS103 4.2 10.4 1.0 C A:CYS111 4.3 10.6 1.0 C A:CYS97 4.3 11.7 1.0 CA A:CYS103 4.4 10.2 1.0 N A:LYS99 4.5 14.7 1.0 C A:GLN96 4.7 11.1 1.0 N A:LYS113 4.8 11.4 1.0 C A:CYS100 4.9 11.3 1.0 O A:CYS100 4.9 11.2 1.0 O A:HOH803 4.9 26.1 1.0 CG A:LYS113 4.9 17.4 1.0 CA A:GLN96 5.0 9.8 1.0

Zinc binding site 3 out of 4 in the Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn401 b:15.1 occ:1.00 NE2 B:HIS67 2.0 12.8 1.0 O B:HOH590 2.1 14.4 1.0 SG B:CYS174 2.3 14.2 1.0 SG B:CYS46 2.3 15.3 1.0 CD2 B:HIS67 3.0 13.6 1.0 CE1 B:HIS67 3.1 13.3 1.0 CB B:CYS46 3.3 13.6 1.0 CB B:CYS174 3.3 11.1 1.0 C5N B:NAI403 3.5 9.2 1.0 O B:HOH568 3.9 24.5 1.0 C4N B:NAI403 4.0 9.9 1.0 OG B:SER48 4.1 13.2 1.0 C6N B:NAI403 4.1 10.4 1.0 CG B:HIS67 4.1 12.7 1.0 ND1 B:HIS67 4.2 13.3 1.0 CB B:SER48 4.2 11.5 1.0 NH2 B:ARG369 4.4 17.1 1.0 CA B:CYS174 4.7 11.8 1.0 CA B:CYS46 4.7 15.1 1.0 OE2 B:GLU68 4.7 16.1 1.0 CE2 B:PHE93 4.7 12.0 1.0 N B:SER48 5.0 13.3 1.0

Zinc binding site 4 out of 4 in the Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Horse Liver Alcohol Dehydrogense His-51-Gln Form Complexed with Nadh within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn402 b:14.1 occ:1.00 SG B:CYS100 2.3 14.4 1.0 SG B:CYS97 2.3 15.5 1.0 SG B:CYS111 2.3 14.0 1.0 SG B:CYS103 2.4 13.5 1.0 CB B:CYS111 3.3 12.3 1.0 CB B:CYS103 3.3 12.6 1.0 CB B:CYS100 3.4 14.7 1.0 CB B:CYS97 3.4 13.0 1.0 N B:CYS97 3.5 14.6 1.0 CA B:CYS111 3.7 12.6 1.0 N B:CYS100 3.9 17.4 1.0 CA B:CYS97 3.9 15.7 1.0 N B:GLY98 4.0 17.6 1.0 N B:LEU112 4.0 14.0 1.0 N B:CYS103 4.2 13.9 1.0 CA B:CYS100 4.2 15.1 1.0 C B:CYS111 4.2 12.5 1.0 CA B:CYS103 4.4 13.4 1.0 C B:CYS97 4.4 16.4 1.0 N B:LYS99 4.5 19.0 1.0 C B:GLN96 4.6 14.4 1.0 N B:LYS113 4.9 14.4 1.0 C B:CYS100 4.9 14.4 1.0 CA B:GLN96 4.9 12.6 1.0 O B:HOH769 4.9 28.0 1.0 CA B:GLY98 5.0 17.0 1.0 O B:CYS100 5.0 14.8 1.0 CG B:LYS113 5.0 18.9 1.0

B.V.Plapp, B.V.Plapp. N/A N/A.