Zinc in PDB 8g2q: Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Gtp

All present enzymatic activity of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Gtp:
2.7.7.86;

The structure of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Gtp, PDB code: 8g2q was solved by S.Wu, J.Sohn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.93 / 2.37
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	78.294, 98.675, 142.827, 90, 90, 90
R / Rfree (%)	20.2 / 24.4

The structure of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Gtp also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Zinc atom in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Gtp (pdb code 8g2q). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Gtp, PDB code: 8g2q:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Gtp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Gtp within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn604 b:32.2 occ:1.00 NE2 A:HIS378 2.0 33.2 1.0 SG A:CYS384 2.3 33.6 1.0 SG A:CYS385 2.3 40.0 1.0 SG A:CYS392 2.3 30.7 1.0 CD2 A:HIS378 2.9 33.6 1.0 CE1 A:HIS378 3.1 34.8 1.0 CB A:CYS392 3.3 36.8 1.0 CB A:CYS385 3.4 33.0 1.0 CB A:CYS384 3.7 32.3 1.0 N A:CYS392 3.8 38.2 1.0 N A:CYS385 3.8 34.2 1.0 C A:CYS384 3.8 35.7 1.0 O A:CYS384 4.0 35.4 1.0 CA A:CYS392 4.0 38.2 1.0 CG A:HIS378 4.1 33.8 1.0 CA A:CYS385 4.1 34.2 1.0 ND1 A:HIS378 4.1 34.5 1.0 CA A:CYS384 4.2 33.8 1.0 NH1 A:ARG394 4.4 35.6 1.0 C A:CYS392 4.5 38.1 1.0 O A:CYS392 4.6 37.8 1.0 O A:ALA390 4.7 39.1 1.0 C A:LYS391 4.8 39.9 1.0

Zinc binding site 2 out of 2 in the Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Gtp


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Gtp within 5.0Å range: probe atom residue distance (Å) B Occ C:Zn604 b:38.1 occ:1.00 NE2 C:HIS378 2.2 32.3 1.0 SG C:CYS384 2.3 32.7 1.0 SG C:CYS385 2.3 37.2 1.0 SG C:CYS392 2.4 35.4 1.0 CD2 C:HIS378 3.0 31.1 1.0 CE1 C:HIS378 3.2 35.2 1.0 CB C:CYS392 3.3 35.1 1.0 CB C:CYS385 3.5 35.6 1.0 CB C:CYS384 3.6 36.5 1.0 N C:CYS392 3.7 40.7 1.0 C C:CYS384 3.8 38.4 1.0 N C:CYS385 3.8 37.8 1.0 O C:CYS384 4.0 35.3 1.0 CA C:CYS392 4.0 40.5 1.0 O C:HOH735 4.1 53.8 1.0 CA C:CYS384 4.2 36.2 1.0 NH1 C:ARG394 4.2 31.9 1.0 CA C:CYS385 4.2 37.6 1.0 CG C:HIS378 4.2 32.4 1.0 ND1 C:HIS378 4.3 31.3 1.0 C C:CYS392 4.6 40.9 1.0 O C:CYS392 4.6 38.6 1.0 O C:HOH713 4.7 39.9 1.0 O C:ALA390 4.8 39.5 1.0 C C:LYS391 4.8 42.7 1.0

S.Wu, J.Sohn. Structure of Ternary Complex of Mouse Cgas with Dsdna and Bound Gtp To Be Published.