Zinc in PDB 8fvi: Human APOBEC3H Bound to Hiv-1 Vif in Complex with Cbf-Beta, Elob, Eloc, and CUL5

All present enzymatic activity of Human APOBEC3H Bound to Hiv-1 Vif in Complex with Cbf-Beta, Elob, Eloc, and CUL5:
3.5.4.38;

The binding sites of Zinc atom in the Human APOBEC3H Bound to Hiv-1 Vif in Complex with Cbf-Beta, Elob, Eloc, and CUL5 (pdb code 8fvi). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human APOBEC3H Bound to Hiv-1 Vif in Complex with Cbf-Beta, Elob, Eloc, and CUL5, PDB code: 8fvi:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Human APOBEC3H Bound to Hiv-1 Vif in Complex with Cbf-Beta, Elob, Eloc, and CUL5


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human APOBEC3H Bound to Hiv-1 Vif in Complex with Cbf-Beta, Elob, Eloc, and CUL5 within 5.0Å range: probe atom residue distance (Å) B Occ 1:Zn201 b:91.5 occ:1.00 NE2 1:HIS108 2.0 34.5 1.0 NE2 1:HIS139 2.0 36.3 1.0 SG 1:CYS133 2.3 51.2 1.0 SG 1:CYS114 2.3 47.0 1.0 CE1 1:HIS139 2.8 37.7 1.0 CD2 1:HIS108 2.9 35.9 1.0 CE1 1:HIS108 3.0 25.5 1.0 CD2 1:HIS139 3.2 36.9 1.0 CB 1:CYS114 3.3 43.9 1.0 CB 1:CYS133 3.3 47.5 1.0 CA 1:CYS114 3.9 44.1 1.0 CG 1:HIS108 4.0 33.0 1.0 ND1 1:HIS108 4.0 26.4 1.0 ND1 1:HIS139 4.0 38.1 1.0 CG 1:HIS139 4.2 39.7 1.0 OE2 0:GLU152 4.3 64.2 1.0 O 1:ASP113 4.4 54.1 1.0 CA 1:CYS133 4.4 49.1 1.0 O 1:TYR135 4.4 41.2 1.0 CG 0:GLU152 4.7 63.5 1.0 N 1:CYS114 4.8 47.6 1.0 CG 0:ARG151 4.8 65.0 1.0 N 1:PHE115 4.9 50.9 1.0 CD 0:GLU152 4.9 64.5 1.0 CE2 1:TYR148 4.9 49.1 1.0 C 1:CYS114 4.9 49.8 1.0 C 1:ASP113 5.0 50.0 1.0

Zinc binding site 2 out of 2 in the Human APOBEC3H Bound to Hiv-1 Vif in Complex with Cbf-Beta, Elob, Eloc, and CUL5


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human APOBEC3H Bound to Hiv-1 Vif in Complex with Cbf-Beta, Elob, Eloc, and CUL5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn401 b:63.2 occ:1.00 ND1 A:HIS54 2.1 51.1 1.0 SG A:CYS88 2.3 32.6 1.0 SG A:CYS85 2.3 41.9 1.0 CE1 A:HIS54 3.0 53.9 1.0 CG A:HIS54 3.1 52.8 1.0 CB A:CYS88 3.3 37.0 1.0 CB A:HIS54 3.4 53.4 1.0 O A:HOH501 3.5 31.5 1.0 CB A:CYS85 3.6 28.8 1.0 N A:CYS85 3.9 40.5 1.0 NE2 A:HIS54 4.1 55.8 1.0 CD2 A:HIS54 4.2 57.1 1.0 N A:CYS88 4.3 22.7 1.0 CA A:CYS85 4.3 33.9 1.0 CA A:CYS88 4.4 24.3 1.0 CA A:HIS54 4.9 54.5 1.0 C A:CYS85 4.9 41.4 1.0 O A:CYS85 4.9 42.6 1.0

F.Ito, A.L.Alvarez-Cabrera, K.Kim, Z.H.Zhou, X.S.Chen. Structural Basis of Hiv-1 Vif-Mediated E3 Ligase Targeting of Host APOBEC3H Nat Commun V. 14 5241 2023.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-023-40955-X