Zinc in PDB 8fo6: Nucleotide-Free Structure of A Functional Construct of Eukaryotic Elongation Factor 2 Kinase.

Enzymatic activity of Nucleotide-Free Structure of A Functional Construct of Eukaryotic Elongation Factor 2 Kinase.

All present enzymatic activity of Nucleotide-Free Structure of A Functional Construct of Eukaryotic Elongation Factor 2 Kinase.:
2.7.11.20;

Protein crystallography data

The structure of Nucleotide-Free Structure of A Functional Construct of Eukaryotic Elongation Factor 2 Kinase., PDB code: 8fo6 was solved by A.Piserchio, E.A.Isiorho, K.N.Dalby, R.Ghose, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.52 / 2.55
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 77.527, 58.901, 88.394, 90, 109.67, 90
R / Rfree (%) 21.7 / 23.1

Other elements in 8fo6:

The structure of Nucleotide-Free Structure of A Functional Construct of Eukaryotic Elongation Factor 2 Kinase. also contains other interesting chemical elements:

Calcium (Ca) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Nucleotide-Free Structure of A Functional Construct of Eukaryotic Elongation Factor 2 Kinase. (pdb code 8fo6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Nucleotide-Free Structure of A Functional Construct of Eukaryotic Elongation Factor 2 Kinase., PDB code: 8fo6:

Zinc binding site 1 out of 1 in 8fo6

Go back to Zinc Binding Sites List in 8fo6
Zinc binding site 1 out of 1 in the Nucleotide-Free Structure of A Functional Construct of Eukaryotic Elongation Factor 2 Kinase.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Nucleotide-Free Structure of A Functional Construct of Eukaryotic Elongation Factor 2 Kinase. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn801

b:52.0
occ:1.00
 NE2 A:HIS312 2.0 47.5 1.0
ND1 A:HIS260 2.1 55.7 1.0
SG A:CYS318 2.3 57.3 1.0
SG A:CYS314 2.3 53.1 1.0
CE1 A:HIS312 2.9 49.1 1.0
CE1 A:HIS260 2.9 57.8 1.0
CB A:CYS318 3.1 58.6 1.0
CD2 A:HIS312 3.1 47.6 1.0
CG A:HIS260 3.1 54.4 1.0
CB A:CYS314 3.2 45.7 1.0
CA A:CYS314 3.3 51.2 1.0
CB A:HIS260 3.6 51.4 1.0
N A:CYS314 4.0 52.3 1.0
ND1 A:HIS312 4.0 44.7 1.0
NE2 A:HIS260 4.1 52.4 1.0
CG A:HIS312 4.2 44.4 1.0
CD2 A:HIS260 4.2 53.7 1.0
C A:CYS314 4.4 57.6 1.0
CA A:CYS318 4.4 55.1 1.0
N A:ASN315 4.5 63.6 1.0
CD1 A:LEU323 4.6 43.0 1.0
CB A:LEU323 4.7 53.4 1.0
C A:ALA313 4.7 52.0 1.0
O A:ALA313 4.8 59.2 1.0

Reference:

A.Piserchio, K.J.Long, L.S.Browning, A.L.Bohanon, E.A.Isiorho, K.N.Dalby, R.Ghose. Adp Enhances the Allosteric Activation of Eukaryotic Elongation Factor 2 Kinase By Calmodulin. Proc.Natl.Acad.Sci.Usa V. 120 02120 2023.
ISSN: ESSN 1091-6490
PubMed: 37068230
DOI: 10.1073/PNAS.2300902120
Page generated: Fri Jul 28 06:53:36 2023

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